Search Results - "Etxeberría, Ainhoa"

Kv7 channels can function without constitutive calmodulin tethering by Gómez-Posada, Juan Camilo, Aivar, Paloma, Alberdi, Araitz, Alaimo, Alessandro, Etxeberría, Ainhoa, Fernández-Orth, Juncal, Zamalloa, Teresa, Roura-Ferrer, Meritxell, Villace, Patricia, Areso, Pilar, Casis, Oscar, Villarroel, Alvaro

“…M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding…”
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Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation by Srinivasan, Karpagam, Friedman, Brad A., Etxeberria, Ainhoa, Huntley, Melanie A., van der Brug, Marcel P., Foreman, Oded, Paw, Jonathan S., Modrusan, Zora, Beach, Thomas G., Serrano, Geidy E., Hansen, David V.

“…Damage-associated microglia (DAM) profiles observed in Alzheimer’s disease (AD)-related mouse models reflect an activation state that could modulate AD risk or…”
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A novel KCNQ4 pore-region mutation (p.G296S) causes deafness by impairing cell-surface channel expression by Mencía, Ángeles, González-Nieto, Daniel, Modamio-Høybjør, Silvia, Etxeberría, Ainhoa, Aránguez, Gracia, Salvador, Nieves, del Castillo, Ignacio, Villarroel, Álvaro, Moreno, Felipe, Barrio, Luis, Moreno-Pelayo, Miguel Ángel

“…Mutations in the potassium channel gene KCNQ4 underlie DFNA2, a subtype of autosomal dominant progressive, high-frequency hearing loss. Based on a…”
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Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis by Mei, Feng, Fancy, Stephen P J, Shen, Yun-An A, Niu, Jianqin, Zhao, Chao, Presley, Bryan, Miao, Edna, Lee, Seonok, Mayoral, Sonia R, Redmond, Stephanie A, Etxeberria, Ainhoa, Xiao, Lan, Franklin, Robin J M, Green, Ari, Hauser, Stephen L, Chan, Jonah R

“…High-throughput screening platform for the testing of small bioactive molecules that promote oligodendrocyte differentiation and remyelination: a new path to…”
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Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum by Gallo, Vittorio, Etxeberria, Ainhoa, Mangin, Jean-Marie, Aguirre, Adan

“…We found that demyelinated axons formed functional glutamatergic synapses onto adult-born NG2+ oligodendrocyte progenitor cells (OPCs) migrating from the…”
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Initiation of CNS Myelination in the Optic Nerve Is Dependent on Axon Caliber by Mayoral, Sonia R., Etxeberria, Ainhoa, Shen, Yun-An A., Chan, Jonah R.

“…Emerging evidence suggests that neuronal signaling is important for oligodendrocyte myelination; however, the necessity of this signaling during development is…”
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Stage-specific deletion of Olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes by Mei, Feng, Wang, Hongkai, Liu, Shubao, Niu, Jianqin, Wang, Lingyun, He, Yangtao, Etxeberria, Ainhoa, Chan, Jonah R, Xiao, Lan

“…The temporal and spatial patterning involved in the specification, differentiation, and myelination by oligodendroglia is coordinated in part by the activation…”
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Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining by Hsiao, Yi-Chun, Wallweber, Heidi Ackerly, Alberstein, Robert G., Lin, Zhonghua, Du, Changchun, Etxeberria, Ainhoa, Aung, Theint, Shang, Yonglei, Seshasayee, Dhaya, Seeger, Franziska, Watkins, Andrew M., Hansen, David V., Bohlen, Christopher J., Hsu, Peter L., Hötzel, Isidro

“…We describe a process for rapid antibody affinity optimization by repertoire mining to identify clones across B cell clonal lineages based on convergent immune…”
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Calmodulin Activation Limits the Rate of KCNQ2 K+ Channel Exit from the Endoplasmic Reticulum by Alaimo, Alessandro, Gómez-Posada, Juan Camilo, Aivar, Paloma, Etxeberría, Ainhoa, Rodriguez-Alfaro, Jose Angel, Areso, Pilar, Villarroel, Alvaro

“…The potential regulation of protein trafficking by calmodulin (CaM) is a novel concept that remains to be substantiated. We proposed that KCNQ2 K+ channel…”
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A pore residue of the KCNQ3 potassium M-channel subunit controls surface expression by Gómez-Posada, Juan Camilo, Etxeberría, Ainhoa, Roura-Ferrer, Meritxell, Areso, Pilar, Masin, Marianela, Murrell-Lagnado, Ruth D, Villarroel, Alvaro

“…KCNQ2 (Kv7.2) and KCNQ3 (Kv7.3) are the principal subunits underlying the potassium M-current, which exerts a strong control on neuronal excitability. KCNQ3…”
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Three Mechanisms Underlie KCNQ2/3 Heteromeric Potassium M-Channel Potentiation by Etxeberria, Ainhoa, Santana-Castro, Irene, Regalado, M. Paz, Aivar, Paloma, Villarroel, Alvaro

“…The non-inactivating potassium M-current exerts a strong influence on neuronal excitability. The channels responsible for this current are made up of KCNQ…”
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Correction: Kv7 Channels Can Function without Constitutive Calmodulin Tethering by Gómez-Posada, Juan Camilo, Aivar, Paloma, Alberdi, Araitz, Alaimo, Alessandro, Etxeberría, Ainhoa, Fernández-Orth, Juncal, Zamalloa, Teresa, Roura-Ferrer, Meritxell, Villace, Patricia, Areso, Pilar, Casis, Oscar, Villarroel, Alvaro

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Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity by Etxeberria, Ainhoa, Hokanson, Kenton C, Dao, Dang Q, Mayoral, Sonia R, Mei, Feng, Redmond, Stephanie A, Ullian, Erik M, Chan, Jonah R

“…Myelin controls the time required for an action potential to travel from the neuronal soma to the axon terminal, defining the temporal manner in which…”
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Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage by Petersen, Mark A., Ryu, Jae Kyu, Chang, Kae-Jiun, Etxeberria, Ainhoa, Bardehle, Sophia, Mendiola, Andrew S., Kamau-Devers, Wanjiru, Fancy, Stephen P.J., Thor, Andrea, Bushong, Eric A., Baeza-Raja, Bernat, Syme, Catriona A., Wu, Michael D., Rios Coronado, Pamela E., Meyer-Franke, Anke, Yahn, Stephanie, Pous, Lauriane, Lee, Jae K., Schachtrup, Christian, Lassmann, Hans, Huang, Eric J., Han, May H., Absinta, Martina, Reich, Daniel S., Ellisman, Mark H., Rowitch, David H., Chan, Jonah R., Akassoglou, Katerina

“…Blood-brain barrier (BBB) disruption alters the composition of the brain microenvironment by allowing blood proteins into the CNS. However, whether…”
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Author Correction: Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis by Mei, Feng, Fancy, Stephen P J, Shen, Yun-An A, Niu, Jianqin, Zhao, Chao, Presley, Bryan, Miao, Edna, Lee, Seonok, Mayoral, Sonia R, Redmond, Stephanie A, Etxeberria, Ainhoa, Xiao, Lan, Franklin, Robin J M, Green, Ari, Hauser, Stephen L, Chan, Jonah R

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A novel KCNQ4 pore-region mutation by Mencía, Ángeles, González-Nieto, Daniel, Modamio-Høybjør, Silvia, Etxeberría, Ainhoa, Aránguez, Gracia, Salvador, Nieves, del Castillo, Ignacio

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Correction: Kv7 Channels Can Function without Constitutive Calmodulin Tethering by Juan Camilo Gómez-Posada, Paloma Aivar, Araitz Alberdi, Alessandro Alaimo, Ainhoa Etxeberría, Juncal Fernández-Orth, Teresa Zamalloa, Meritxell Roura-Ferrer, Patricia Villace, Pilar Areso, Oscar Casis, Alvaro Villarroel

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Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism by Schauer, Stephen P., Cho, Chang Hoon, Novikova, Gloriia, Roth, Gillie A., Lee, Julie, Sharma, Anup D., Foley, Alejandro R., Ng, Carl, Shen, Philip, Choi, Meena, Ma, Taylur P., Phu, Lilian, Budayeva, Hanna G., Cheung, Tommy K., Lalehzadeh, Guita, Imperio, Jose, Ngu, Hai, Etxeberria, Ainhoa, Liang, Yuxin, Rezzonico, Mitchell G., Dourado, Michelle, Huang, Kevin, Lai, Zijuan, Hokom, Martha, Pandya, Nikhil J., Newton, Dwight, Abdel‐Haleem, Alyaa M., Chan, Pamela, Lee, Donna, Tassew, Nardos G., Sangaraju, Dewakar, O'Connor, Deborah, Hötzel, Isidro, Stark, Kimberly L., Chou, Carolina, Foreman, Oded, Easton, Amy, Wildsmith, Kristin R., Sperinde, Gizette, Rose, Christopher M., Friedman, Brad A., Fuji, Reina N., Weimer, Robby M., Meilandt, William J., Sadekar, Shraddha, Nugent, Alicia A., Biever, Anne

“…INTRODUCTION Triggering receptor expressed on myeloid cells 2 (TREM2) agonists are being clinically evaluated as disease‐modifying therapeutics for Alzheimer's…”
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Lack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutants by Alaimo, Alessandro, Etxeberria, Ainhoa, Gómez-Posada, Juan Camilo, Gomis-Perez, Carolina, Fernández-Orth, Juncal, Malo, Covadonga, Villarroel, Alvaro

“…Heteromers of Kv7.2/Kv7.3 subunits constitute the main substrate of the neuronal M-current that limits neuronal hyper-excitability and firing frequency…”
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Calmodulin regulates the trafficking of KCNQ2 potassium channels by Etxeberria, Ainhoa, Aivar, Paloma, Rodriguez-Alfaro, Jose Angel, Alaimo, Alessandro, Villacé, Patricia, Gómez-Posada, Juan Camilo, Areso, Pilar, Villarroel, Alvaro

“…Voltage-dependent potassium KCNQ2 (Kv7.2) channels play a prominent role in the control of neuronal excitability. These channels must associate with calmodulin…”
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