Search Results - "Ettrich, Rudiger"

Conserved Dynamic Mechanism of Allosteric Response to L-arg in Divergent Bacterial Arginine Repressors by Pandey, Saurabh Kumar, Melichercik, Milan, Řeha, David, Ettrich, Rüdiger H, Carey, Jannette

“…Hexameric arginine repressor, ArgR, is the feedback regulator of bacterial L-arginine regulons, and sensor of L-arg that controls transcription of genes for…”
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Mechanistic insights into the Orai channel by molecular dynamics simulations by Bonhenry, Daniel, Schober, Romana, Schmidt, Tony, Waldherr, Linda, Ettrich, Rüdiger H., Schindl, Rainer

“…Highly Ca2+ selective channels trigger a large variety of cellular signaling processes in both excitable and non-excitable cells. Among these channels, the…”
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Role of aspartic acid residues D87 and D89 in APS kinase domain of human 3′-phosphoadenosine 5′-phosphosulfate synthase 1 and 2b: A commonality with phosphatases/kinases by Venkatachalam, K.V., Ettrich, Rudiger H.

“…3′-phosphoadenosine 5′-phosphosulfate (PAPS) is synthesized in two steps by PAPS synthase (PAPSS). PAPSS is comprised of ATP sulfurylase (ATPS) and APS kinase…”
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Engineering Enzyme Stability and Resistance to an Organic Cosolvent by Modification of Residues in the Access Tunnel by Koudelakova, Tana, Chaloupkova, Radka, Brezovsky, Jan, Prokop, Zbynek, Sebestova, Eva, Hesseler, Martin, Khabiri, Morteza, Plevaka, Maryia, Kulik, Daryna, Kuta Smatanova, Ivana, Rezacova, Pavlina, Ettrich, Rudiger, Bornscheuer, Uwe T., Damborsky, Jiri

“…Mutations targeting as few as four residues lining the access tunnel extended the half‐life of an enzyme in 40 % dimethyl sulfoxide from minutes to weeks and…”
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The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1 by Samad, Abdul, Sura, Lucie, Benedikt, Jan, Ettrich, Rudiger, Minofar, Babak, Teisinger, Jan, Vlachova, Viktorie

“…The ankyrin transient receptor potential channel TRPA1 is a non-selective cationic channel that is expressed by sensory neurons, where it can be activated by…”
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A computational study of the oligosaccharide binding sites in the lectin-like domain of Tumor Necrosis Factor and the TNF-derived TIP peptide by Dulebo, Alexander, Ettrich, Rudiger, Lucas, Rudolf, Kaftan, David

“…The lectin-like domain of Tumor Necrosis Factor (TNF), mimicked by the TIP peptide, activates amiloride-sensitive sodium uptake in type II alveolar epithelial…”
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Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain by Zayats, Vasilina, Samad, Abdul, Minofar, Babak, Roelofs, Katherine E., Stockner, Thomas, Ettrich, Rudiger

“…The transient receptor potential channel A1 (TRPA1) is unique among ion channels of higher vertebrates in that it harbors a large ankyrin repeat domain. The…”
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Inhibition of human serine racemase, an emerging target for medicinal chemistry by Jirásková-Vaníčková, Jana, Ettrich, Rudiger, Vorlová, Barbora, Hoffman, Hillary E, Lepšík, Martin, Jansa, Petr, Konvalinka, Jan

“…Proteins of glutamatergic NMDA receptor signaling pathways have been studied as targets for intervention in a variety of neuropathological conditions,…”
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Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription by Frischauf, Irene, Litviňuková, Monika, Schober, Romana, Zayats, Vasilina, Svobodová, Barbora, Bonhenry, Daniel, Lunz, Victoria, Cappello, Sabrina, Tociu, Laura, Reha, David, Stallinger, Amrutha, Hochreiter, Anna, Pammer, Teresa, Butorac, Carmen, Muik, Martin, Groschner, Klaus, Bogeski, Ivan, Ettrich, Rüdiger H, Romanin, Christoph, Schindl, Rainer

“…The channel Orai1 requires Ca store depletion in the endoplasmic reticulum and an interaction with the Ca sensor STIM1 to mediate Ca signaling. Alterations in…”
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Communication between N terminus and loop2 tunes Orai activation by Fahrner, Marc, Pandey, Saurabh K., Muik, Martin, Traxler, Lukas, Butorac, Carmen, Stadlbauer, Michael, Zayats, Vasilina, Krizova, Adéla, Plenk, Peter, Frischauf, Irene, Schindl, Rainer, Gruber, Hermann J., Hinterdorfer, Peter, Ettrich, Rüdiger, Romanin, Christoph, Derler, Isabella

“…Ca2+ release-activated Ca2+ (CRAC) channels constitute the major Ca2+ entry pathway into the cell. They are fully reconstituted via intermembrane coupling of…”
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Computational study of β-N-acetylhexosaminidase from Talaromyces flavus, a glycosidase with high substrate flexibility by Kulik, Natallia, Slámová, Kristýna, Ettrich, Rüdiger, Křen, Vladimír

“…β-N-Acetylhexosaminidase (GH20) from the filamentous fungus Talaromyces flavus, previously identified as a prominent enzyme in the biosynthesis of modified…”
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A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription by Frischauf, Irene, Zayats, Vasilina, Deix, Michael, Hochreiter, Anna, Jardin, Isaac, Muik, Martin, Lackner, Barbara, Svobodová, Barbora, Pammer, Teresa, Litviňuková, Monika, Sridhar, Amrutha Arumbakam, Derler, Isabella, Bogeski, Ivan, Romanin, Christoph, Ettrich, Rüdiger H, Schindl, Rainer

“…The Ca(2+) release-activated Ca(2+) channel mediates Ca(2+) influx in a plethora of cell types, thereby controlling diverse cellular functions. The channel…”
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Cholesterol modulates Orai1 channel function by Derler, Isabella, Jardin, Isaac, Stathopulos, Peter B, Muik, Martin, Fahrner, Marc, Zayats, Vasilina, Pandey, Saurabh K, Poteser, Michael, Lackner, Barbara, Absolonova, Marketa, Schindl, Rainer, Groschner, Klaus, Ettrich, Rüdiger, Ikura, Mitsu, Romanin, Christoph

“…STIM1 (stromal interaction molecule 1) and Orai proteins are the essential components of Ca(2+) release-activated Ca(2+) (CRAC) channels. We focused on the…”
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Crystal structure of a novel domain of the motor subunit of the Type I restriction enzyme EcoR124 involved in complex assembly and DNA binding by Grinkevich, Pavel, Sinha, Dhiraj, Iermak, Iuliia, Guzanova, Alena, Weiserova, Marie, Ludwig, Jost, Mesters, Jeroen R., Ettrich, Rüdiger H.

“…Although EcoR124 is one of the better-studied Type I restriction-modification enzymes, it still presents many challenges to detailed analyses because of its…”
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Charybdotoxin Unbinding from the mKv1.3 Potassium Channel: A Combined Computational and Experimental Study by Khabiri, Morteza, Nikouee, Azadeh, Cwiklik, Lukasz, Grissmer, Stephan, Ettrich, Rüdiger

“…Charybdotoxin, belonging to the group of so-called scorpion toxins, is a short peptide able to block many voltage-gated potassium channels, such as mKv1.3,…”
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Sequential activation of STIM1 links Ca 2+ with luminal domain unfolding by Schober, Romana, Bonhenry, Daniel, Lunz, Victoria, Zhu, Jinhui, Krizova, Adela, Frischauf, Irene, Fahrner, Marc, Zhang, MengQi, Waldherr, Linda, Schmidt, Tony, Derler, Isabella, Stathopulos, Peter B, Romanin, Christoph, Ettrich, Rüdiger H, Schindl, Rainer

“…The stromal interaction molecule 1 (STIM1) has two important functions, Ca sensing within the endoplasmic reticulum and activation of the store-operated Ca…”
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Quantum Calculations Indicate Effective Electron Transfer between FMN and Benzoquinone in a New Crystal Structure of Escherichia coli WrbA by Degtjarik, Oksana, Brynda, Jiři, Ettrichova, Olga, Kuty, Michal, Sinha, Dhiraj, Kuta Smatanova, Ivana, Carey, Jannette, Ettrich, Rüdiger, Řeha, David

“…Quantum mechanical calculations using the Marcus equation are applied to compare the electron-transfer probability for two distinct crystal structures of the…”
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Functional Role of C-Terminal Cytoplasmic Tail of Rat Vanilloid Receptor 1 by Vlachova, Viktorie, Teisinger, Jan, Susankova, Klara, Lyfenko, Alla, Ettrich, Rudiger, Vyklicky, Ladislav

“…The vanilloid receptor [transient receptor potential (TRP)V1, also known as VR1] is a member of the TRP channel family. These receptors share a significant…”
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Charybdotoxin and Margatoxin Acting on the Human Voltage-Gated Potassium Channel hKv1.3 and Its H399N Mutant: An Experimental and Computational Comparison by Nikouee, Azadeh, Khabiri, Morteza, Grissmer, Stephan, Ettrich, Rüdiger

“…The effect of the pore-blocking peptides charybdotoxin and margatoxin, both scorpion toxins, on currents through human voltage-gated hKv1.3 wild-type and…”
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A residue of motif III positions the helicase domains of motor subunit HsdR in restriction-modification enzyme EcoR124I by Sinha, Dhiraj, Bialevich, Vitali, Shamayeva, Katsiaryna, Guzanova, Alena, Sisakova, Alexandra, Csefalvay, Eva, Reha, David, Krejci, Lumir, Carey, Jannette, Weiserova, Marie, Ettrich, Rüdiger

“…Type I restriction-modification enzymes differ significantly from the type II enzymes commonly used as molecular biology reagents. On hemi-methylated DNAs type…”
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