Search Results - "Etrych, T."

Polymeric nanogels as drug delivery systems by Kousalová, J, Etrych, T

“…The present review focuses on the description of the design, synthesis and physico-chemical and biological evaluation of polymer nanogels. Nanogels are robust…”
Get full text

High-molecular-weight HPMA-based polymer drug carriers for delivery to tumor by Kostka, L, Etrych, T

“…In this work, design and synthesis of high-molecular-weight N-(2-hydroxypropyl)methacrylamide-based polymer drug delivery systems tailored for cancer therapy…”
Get full text

Cell-penetrating peptides: a useful tool for the delivery of various cargoes into cells by Böhmová, E, Machová, D, Pechar, M, Pola, R, Venclíková, K, Janoušková, O, Etrych, T

“…Cell-penetrating compounds are substances that enhance the cellular uptake of various molecular cargoes that do not easily cross the cellular membrane. The…”
Get full text

Polymer-drug conjugates in inflammation treatment by Koziolová, E, Venclíková, K, Etrych, T

“…Inflammation is a vital defense mechanism of living organisms. However, persistent and chronic inflammation may lead to severe pathological processes and…”
Get full text

Adaptable polymerization platform for therapeutics with tunable biodegradability by Hrochová, M., Kotrchová, L., Frejková, M., Konefał, R., Gao, S., Fang, J., Kostka, L., Etrych, T.

“…Biodegradable polymer-based therapeutics have recently become essential drug delivery biomaterials for various bioactive compounds. Biodegradable and…”
Get full text

Overcoming multidrug resistance using folate receptor-targeted and pH-responsive polymeric nanogels containing covalently entrapped doxorubicin by Chen, Y, Tezcan, O, Li, D, Beztsinna, N, Lou, B, Etrych, T, Ulbrich, K, Metselaar, J M, Lammers, T, Hennink, W E

“…Multidrug resistance (MDR) contributes to failure of chemotherapy. We here show that biodegradable polymeric nanogels are able to overcome MDR via folic acid…”
Get more information

Size-switchable polymer-based nanomedicines in the advanced therapy of rheumatoid arthritis by Libánská, A., Randárová, E., Skoroplyas, S., Bartoš, M., Luňáčková, J., Lager, F., Renault, G., Scherman, D., Etrych, T.

“…Chronic inflammatory diseases such as rheumatoid arthritis represent a substantial socio-economic impact and have a high prevalence in the modern world…”
Get full text

Polymer nitric oxide donors potentiate the treatment of experimental solid tumours by increasing drug accumulation in the tumour tissue by Studenovsky, M., Sivak, L., Sedlacek, O., Konefal, R., Horkova, V., Etrych, T., Kovar, M., Rihova, B., Sirova, M.

“…The delivery of nitric oxide (NO) specifically to solid tumours was explored in this study as a strategy to augment the passive accumulation of nanomedicines…”
Get full text

Synthesis of water-soluble star polymers based on cyclodextrins by Kotrchová, L, Etrych, T

“…Novel star polymers based on the water-soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer and cyclodextrin were synthesized and the physico-chemical…”
Get full text

Drug carriers with star polymer structures by Kotrchová, L, Kostka, L, Etrych, T

“…In this review we summarize several synthetic approaches to the advanced synthesis of star-like polymer-based drug carriers. Moreover, their application as…”
Get full text

Chemosensitization of tumors via simultaneous delivery of STAT3 inhibitor and doxorubicin through HPMA copolymer-based nanotherapeutics with pH-sensitive activation by Kovář, M., Šubr, V., Běhalová, K., Studenovský, M., Starenko, D., Kovářová, J., Procházková, P., Etrych, T., Kostka, L.

“…We synthesized three novel STAT3 inhibitors (S3iD1-S3iD3) possessing oxoheptanoic residue enabling linkage to HPMA copolymer carrier via a pH-sensitive…”
Get full text

Biocompatible glyconanomaterials based on HPMA-copolymer for specific targeting of galectin-3 by Bojarová, P, Tavares, M R, Laaf, D, Bumba, L, Petrásková, L, Konefał, R, Bláhová, M, Pelantová, H, Elling, L, Etrych, T, Chytil, P, Křen, V

“…Galectin-3 (Gal-3) is a promising target in cancer therapy with a high therapeutic potential due to its abundant localization within the tumor tissue and its…”
Get full text

The pH-dependent and enzymatic release of cytarabine from hydrophilic polymer conjugates by Pola, R, Janoušková, O, Etrych, T

“…Cytarabine is one of the most efficient drugs in the treatment of hematological malignancies. In this work, we describe the synthesis and characterization of…”
Get full text

Synthesis of Well-Defined Semitelechelic Poly[N‑(2-hydroxypropyl)methacrylamide] Polymers with Functional Group at the α‑End of the Polymer Chain by RAFT Polymerization by Šubr, V, Kostka, L, Strohalm, J, Etrych, T, Ulbrich, K

“…N-(2-Hydroxypropyl)methacrylamide polymer precursors (pHPMA) with very narrow distribution of molecular weights and polymer chain terminating in a single…”
Get full text

HPMA copolymer-based polymer conjugates for the delivery and controlled release of retinoids by Lidický, O, Šírová, M, Etrych, T

“…In this paper, we describe the synthesis, physicochemical characterization, drug release kinetics and preliminary biological evaluation of several…”
Get full text

HPMA copolymer-bound doxorubicin induces immunogenic tumor cell death by Sirova, M, Kabesova, M, Kovar, L, Etrych, T, Strohalm, J, Ulbrich, K, Rihova, B

“…Treatment of murine EL4 T cell lymphoma with N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugates of doxorubicin (Dox) leads to complete tumor…”
Get more information

New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting by Chytil, P., Etrych, T., Koňák, Č., Šírová, M., Mrkvan, T., Bouček, J., Říhová, B., Ulbrich, K.

“…Various conjugates of anticancer drug doxorubicin (Dox) covalently bound by the hydrolytically degradable hydrazone bond to the drug carrier based on…”
Get full text

HPMA copolymers with pH-controlled release of doxorubicin: In vitro cytotoxicity and in vivo antitumor activity by Ulbrich, K, Etrych, T, Chytil, P, Jelı́nková, M, Řı́hová, B

“…Data on the synthesis, physicochemical characterisation and in vitro and in vivo biological properties of the new, nontargeted or antibody-targeted…”
Get full text

Novel star HPMA-based polymer conjugates for passive targeting to solid tumors by Etrych, T., Strohalm, J., Chytil, P., íhová, B., Ulbrich, K.

“…Novel star polymer-doxorubicin conjugates designed for passive tumor targeting have been developed and their potential for treatment of cancer has been…”
Get full text

Intracellular fate of polymer therapeutics investigated by fluorescence lifetime imaging and fluorescence pattern analysis by Panek, J, Koziolova, E, Stepanek, P, Etrych, T, Janouskova, O

“…Nanocarriers bearing anticancer drugs are promising candidates to improve the efficacy of cancer therapy and minimize side effects. The most potent cytostatics…”
Get full text