Long-lasting effects of minocycline on behavior in young but not adult Fragile X mice

Highlights • Effectiveness of minocycline treatment in alleviating FXS-like behaviors in Fmr1 KO mice. • Minocycline reduces locomotor activity and anxiety in young and adult Fmr1 KO mice. • Continuous minocycline treatment is required to maintain the effects in adult Fmr1 KO mice. • Beneficial effe...

Full description

Saved in:

Bibliographic Details
Published in:	Neuroscience Vol. 246; pp. 186 - 198
Main Authors:	Dansie, L.E, Phommahaxay, K, Okusanya, A.G, Uwadia, J, Huang, M, Rotschafer, S.E, Razak, K.A, Ethell, D.W, Ethell, I.M
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ltd 29-08-2013 Elsevier
Subjects:	Age Factors Animals Animals, Newborn anxiety audiogenic seizures Biological and medical sciences Chromosome fragility (bloom syndrome, ataxia telangiectasia, fanconi anemia, x-linked mental retardation...) Fragile X Mental Retardation Protein - genetics Fragile X Mental Retardation Protein - metabolism Fragile X Syndrome Fragile X Syndrome - drug therapy Fragile X Syndrome - genetics Fragile X Syndrome - metabolism Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy hyperactivity Maze Learning - drug effects Maze Learning - physiology Medical genetics Medical sciences Mice Mice, 129 Strain Mice, Knockout minocycline Minocycline - pharmacology Minocycline - therapeutic use Motor Activity - drug effects Motor Activity - physiology Nervous system (semeiology, syndromes) Neurology perseverance Time Factors Treatment Outcome FXS phosphorylation of serine least significant difference hyperactivity FMR1 phosphoinositide-3 kinase Fragile X mental retardation gene knock-out perseverance Fragile X mental retardation gene WRJ Fmr1 KO Fragile X mental retardation protein analysis of variance PI3K ANOVA minocycline ethylenediaminetetraacetic acid wild running and jumping dfmr1 LSD WT GSK pS pT FMRP Fragile X Syndrome phosphorylation of threonine mitogen activated protein kinase pY drosophila Fragile X Syndrome model EDTA MAPK MCB EGTA phosphorylation of tyrosine MMP anxiety audiogenic seizures enzyme-linked immunosorbent assay glycogen synthase kinase multiple comparison with the best matrix metalloproteinase ethylene glycol tetraacetic acid wild-type ELISA Chromosome fragility Nervous system diseases Rodentia Cerebral disorder Audiogenic epilepsy Vertebrata Mammalia Mouse Animal Central nervous system disease Minocycline Anxiety Behavior Fragile X syndrome
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Highlights • Effectiveness of minocycline treatment in alleviating FXS-like behaviors in Fmr1 KO mice. • Minocycline reduces locomotor activity and anxiety in young and adult Fmr1 KO mice. • Continuous minocycline treatment is required to maintain the effects in adult Fmr1 KO mice. • Beneficial effects of minocycline on perseverative behavior in Fmr1 KO mice. • Minocycline partially attenuates the number and severity of audiogenic seizures in Fmr1 KO mice.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.04.058