Search Results - "Eteläinen, Tony"

Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α‑Synuclein Mouse Models of Parkinson’s Disease by Kilpeläinen, Tommi P., Pätsi, Henri T., Svarcbahs, Reinis, Julku, Ulrika H., Eteläinen, Tony S., Cui, Hengjing, Auno, Samuli, Sipari, Nina, Norrbacka, Susanna, Leino, Teppo O., Jäntti, Maria, Myöhänen, Timo T., Wallén, Erik A. A.

“…Prolyl oligopeptidase (PREP) is a widely distributed serine protease in the human body cleaving proline-containing peptides; however, recent studies suggest…”
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Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model by Eteläinen, Tony S., Kilpeläinen, Tommi P., Ignatius, Adele, Auno, Samuli, De Lorenzo, Francesca, Uhari-Väänänen, Johanna K., Julku, Ulrika H., Myöhänen, Timo T.

“…Parkinson's disease (PD) is characterized by degeneration of nigrostriatal dopaminergic neurons and accumulation of α-synuclein (αSyn) as Lewy bodies…”
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Repeated Ethanol Exposure Alters DNA Methylation Status and Dynorphin/Kappa-Opioid Receptor Expression in Nucleus Accumbens of Alcohol-Preferring AA Rats by Niinep, Kerly, Anier, Kaili, Eteläinen, Tony, Piepponen, Petteri, Kalda, Anti

“…Growing evidence suggests that epigenetic mechanisms, such as DNA methylation and demethylation, and histone modifications, are involved in the development of…”
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A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy by Eteläinen, Tony S, Silva, M Catarina, Uhari-Väänänen, Johanna K, De Lorenzo, Francesca, Jäntti, Maria H, Cui, Hengjing, Chavero-Pieres, Marta, Kilpeläinen, Tommi, Mechtler, Christina, Svarcbahs, Reinis, Seppälä, Erin, Savinainen, Juha R, Puris, Elena, Fricker, Gert, Gynther, Mikko, Julku, Ulrika H, Huttunen, Henri J, Haggarty, Stephen J, Myöhänen, Timo T

“…Tauopathies are neurodegenerative diseases that are characterized by accumulation of hyperphosphorylated tau protein, higher-order aggregates, and tau…”
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Tetrazole as a Replacement of the Electrophilic Group in Characteristic Prolyl Oligopeptidase Inhibitors by Kilpeläinen, Tommi P, Tyni, Jonna K, Lahtela-Kakkonen, Maija K, Eteläinen, Tony S, Myöhänen, Timo T, Wallén, Erik A. A

“…4-Phenylbutanoyl-aminoacyl-2­(S)-tetrazolylpyrrolidines were studied as prolyl oligopeptidase inhibitors. The compounds were more potent than expected from the…”
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The selective κ-opioid receptor antagonist JDTic attenuates the alcohol deprivation effect in rats by Uhari-Väänänen, Johanna, Eteläinen, Tony, Bäckström, Pia, Oinio, Ville, Carroll, F. Ivy, Raasmaja, Atso, Kiianmaa, Kalervo, Piepponen, Petteri

“…•Systemic and intra-accumbens shell JDTic, a κ-antagonist, attenuated the ADE in rats.•A low dose of naltrexone inhibited the ADE and decreased ethanol…”
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Novel Small‐Molecular Ligands for Prolyl Oligopeptidase to Combat Tauopathies by Eteläinen, Tony, Pätsi, Henri, Uhari‐Väänänen, Johanna, Aikkila, Hannes, Cui, Hengjing, De Lorenzo, Francesca, Kilpeläinen, Tommi, Julku, Ulrika, Wallén, Erik A.A., Myöhänen, Timo T

“…Background Tauopathies that include e.g. frontotemporal dementia and Alzheimer’s disease, are neurodegenerative diseases characterized by accumulation of…”
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