Search Results - "Eszter Szabó, Judit"
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Redox status of cysteines does not alter functional properties of human dUTPase but the Y54C mutation involved in monogenic diabetes decreases protein stability
Published in Scientific reports (28-09-2021)“…Recently it was proposed that the redox status of cysteines acts as a redox switch to regulate both the oligomeric status and the activity of human dUTPase. In…”
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In Vitro Analysis of Predicted DNA-Binding Sites for the Stl Repressor of the Staphylococcus aureus SaPIBov1 Pathogenicity Island
Published in PloS one (07-07-2016)“…The regulation model of the Staphylococcus aureus pathogenicity island SaPIbov1 transfer was recently reported. The repressor protein Stl obstructs the…”
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The Role of a Key Amino Acid Position in Species-Specific Proteinaceous dUTPase Inhibition
Published in Biomolecules (Basel, Switzerland) (06-06-2019)“…Protein inhibitors of key DNA repair enzymes play an important role in deciphering physiological pathways responsible for genome integrity, and may also be…”
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Design, synthesis and biological evaluation of novel cyclic malonamide derivatives as selective RIPK1 inhibitors
Published in Bioorganic & medicinal chemistry letters (01-03-2024)“…[Display omitted] Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) plays a key role in cell death and inflammation. RIPK1 is a well-established…”
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Harnessing dual-mode RIPK1 ligands for cross-species anti-necroptosis inhibitor compounds
Published in Bioorganic & medicinal chemistry letters (15-11-2024)“…[Display omitted] •Synthesis and biological evaluation of novel mixed type RIPK1 inhibitors.•Installation of a rigid acetylene moiety enhanced the…”
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A user-friendly, high-throughput tool for the precise fluorescent quantification of deoxyribonucleoside triphosphates from biological samples
Published in Nucleic acids research (07-05-2020)“…Cells maintain a fine-tuned, dynamic concentration balance in the pool of deoxyribonucleoside 5'-triphosphates (dNTPs). This balance is essential for…”
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