Search Results - "Esue, Osigwe"

Auristatin Antibody Drug Conjugate Physical Instability and the Role of Drug Payload by Adem, Yilma T, Schwarz, Kelly A, Duenas, Eileen, Patapoff, Thomas W, Galush, William J, Esue, Osigwe

“…The conjugation of hydrophobic cytotoxic agents such as monomethyl auristatin E (MMAE) to the interchain sulfhydryl groups of monoclonal antibodies (Mabs)…”
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Alpha-actinin and filamin cooperatively enhance the stiffness of actin filament networks by Esue, Osigwe, Tseng, Yiider, Wirtz, Denis

“…The close subcellular proximity of different actin filament crosslinking proteins suggests that these proteins may cooperate to organize F-actin structures to…”
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A Direct Interaction between Actin and Vimentin Filaments Mediated by the Tail Domain of Vimentin by Esue, Osigwe, Carson, Ashley A., Tseng, Yiider, Wirtz, Denis

“…The assembly and organization of the three major eukaryotic cytoskeleton proteins, actin, microtubules, and intermediate filaments, are highly interdependent…”
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Polysorbate 20 prevents the precipitation of a monoclonal antibody during shear by Patapoff, Thomas W., Esue, Osigwe

“…Monoclonal antibodies (MAbs) are widely used as therapeutic proteins and they are frequently exposed to a high degree of stress during manufacturing or…”
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The Assembly of MreB, a Prokaryotic Homolog of Actin by Esue, Osigwe, Cordero, Maria, Wirtz, Denis, Tseng, Yiider

“…MreB, a major component of the bacterial cytoskeleton, exhibits high structural homology to its eukaryotic counterpart actin. Live cell microscopy studies…”
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The Filamentous Actin Cross-Linking/Bundling Activity of Mammalian Formins by Esue, Osigwe, Harris, Elizabeth S., Higgs, Henry N., Wirtz, Denis

“…Formins are multidomain proteins that regulate actin filament dynamics and are defined by the formin homology 2 domain. Biochemical assays suggest that…”
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GTPase Activity, Structure, and Mechanical Properties of Filaments Assembled from Bacterial Cytoskeleton Protein MreB by ESUE, Osigwe, WIRTZ, Denis, TSENG, Yiider

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Bimodal Role of Filamin in Controlling the Architecture and Mechanics of F-actin Networks by Tseng, Yiider, An, Kwang M., Esue, Osigwe, Wirtz, Denis

“…Reconstituted actin filament networks have been used extensively to understand the mechanics of the actin cortex and decipher the role of actin cross-linking…”
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Dynamics of the bacterial intermediate filament crescentin in vitro and in vivo by Esue, Osigwe, Rupprecht, Laura, Sun, Sean X, Wirtz, Denis

“…Crescentin, the recently discovered bacterial intermediate filament protein, organizes into an extended filamentous structure that spans the length of the…”
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Hexyl glucoside and hexyl maltoside inhibit light-induced oxidation of tryptophan by Adem, Yilma T, Molina, Patricia, Liu, Hongbin, Patapoff, Thomas W, Sreedhara, Alavattam, Esue, Osigwe

“…We investigated the photo-protective effect of sugar-based surfactants--hexyl glucoside and hexyl maltoside--against light-induced oxidation of a monoclonal…”
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Actinin and Filamin Cooperatively Enhance the Stiffness of Actin Filament Networks by Esue, Osigwe, Tseng, Yiider, Wirtz, Denis

“…Background The close subcellular proximity of different actin filament crosslinking proteins suggests that these proteins may cooperate to organize F-actin…”
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Carboxylate-Dependent Gelation of a Monoclonal Antibody by Esue, Osigwe, Kanai, Sonoko, Liu, Jun, Patapoff, Thomas W, Shire, Steven J

“…Purpose This paper shows the first ever assembly of monoclonal antibody using multivalent carboxylate ions into highly ordered structures that feature…”
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Thermodynamic and structural characterization of an antibody gel by Esue, Osigwe, Xie, Anna X., Kamerzell, Tim J., Patapoff, Thomas W.

“…Although extensively studied, protein-protein interactions remain highly elusive and are of increasing interest in drug development. We show the assembly of a…”
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Characterization of a nutrient feed precipitate from an E. coli fermentation process by Speciner, Lauren, Mallon, Erin, Leung, Susan, Laird, Michael W., Esue, Osigwe

“…Metalloproteins require soluble metal ions such as zinc to properly fold into their native and active state to maintain stability and biological activity. When…”
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Polysorbate 20 prevents the precipitation of a monoclonal antibody during shear by Patapoff, Thomas W, Esue, Osigwe

“…Monoclonal antibodies (MAbs) are widely used as therapeutic proteins and they are frequently exposed to a high degree of stress during manufacturing or…”
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The rapid onset of elasticity during the assembly of the bacterial cell-division protein FtsZ by Esue, Osigwe, Tseng, Yiider, Wirtz, Denis

“…FtsZ, a prokaryotic homolog of eukaryotic tubulin, is a major constituent of the bacterial Z-ring, which contracts the cell wall during cell division. Because…”
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Mechanical shear can accelerate the gelation of actin filament networks by ESUE, Osigwe, TSENG, Yiider, WIRTZ, Denis

“…Rearrangements of the filamentous actin cytoskeleton at the leading edge of motile cells occur under large mechanical stresses. Contrary to conventional…”
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Dynamics and micromechanics of the cytoskeleton by Esue, Osigwe

“…MreB, FtsZ, and crescentin are highly homologous to eukaryotic actin, tubulin, and intermediate filaments respectively. Depletion of genes coding for MreB…”
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