Prediabetes Induces More Severe Acute COVID-19 Associated With IL-6 Production Without Worsening Long-Term Symptoms

Prediabetes Induces More Severe Acute COVID-19 Associated With IL-6 Production Without Worsening Long-Term Symptoms

Pre-existing conditions, such as age, hypertension, obesity, and diabetes, constitute known risk factors for severe COVID-19. However, the impact of prediabetes mellitus (PDM) on COVID-19 severity is less clear. This study aimed to evaluate the influence of PDM in the acute and long-term phases of C...

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Published in:Frontiers in endocrinology (Lausanne) Vol. 13; p. 896378
Main Authors: Bonyek-Silva, Icaro, Cerqueira-Silva, Thiago, Nunes, Sara, Machado, Antônio Fernando Araújo, Cruz, Márcio Rivison Silva, Pereira, Blenda, Estrela, Leilane, Silva, Jéssica, Isis, Ananda, Barral, Aldina, Oliveira, Pablo Rafael Silveira, Khouri, Ricardo, Serezani, C Henrique, Brodskyn, Cláudia, Caldas, Juliana Ribeiro, Barral-Netto, Manoel, Boaventura, Viviane, Tavares, Natalia Machado
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 08-07-2022
Subjects:
COVID-19
COVID-19 - complications
Diabetes Mellitus
Endocrinology
Hospitalization
Humans
IL-6
inflammation
Interleukin-6 - biosynthesis
long COVID
prediabetes
Prediabetic State - complications
COVID-19
long COVID
inflammation
prediabetes
IL-6
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Summary:Pre-existing conditions, such as age, hypertension, obesity, and diabetes, constitute known risk factors for severe COVID-19. However, the impact of prediabetes mellitus (PDM) on COVID-19 severity is less clear. This study aimed to evaluate the influence of PDM in the acute and long-term phases of COVID-19. We compared inflammatory mediators, laboratory and clinical parameters and symptoms in COVID-19 patients with prediabetes (PDM) and without diabetes (NDM) during the acute phase of infection and at three months post-hospitalization. Patients with PDM had longer hospital stays and required intensive care unit admission more frequently than NDM. Upon hospitalization, PDM patients exhibited higher serum levels of interleukin 6 (IL-6), which is related to reduced partial pressure of oxygen (PaO ) in arterial blood, oxygen saturation (SpO ) and increased COVID-19 severity. However, at three months after discharge, those with PDM did not exhibit significant alterations in laboratory parameters or residual symptoms; however, PDM was observed to influence the profile of reported symptoms. PDM seems to be associated with increased risk of severe COVID-19, as well as higher serum levels of IL-6, which may constitute a potential biomarker of severe COVID-19 risk in affected patients. Furthermore, while PDM correlated with more severe acute-phase COVID-19, no long-term worsening of sequelae was observed.
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These authors have contributed equally to this work
This article was submitted to Diabetes: Molecular Mechanisms, a section of the journal Frontiers in Endocrinology
Edited by: Francesco Prattichizzo, MultiMedica Holding SpA (IRCCS), Italy
Reviewed by: Celestino Sardu, University of Campania Luigi Vanvitelli, Italy; Elettra Mancuso, University of Magna Graecia, Italy
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.896378