Search Results - "Estick, Candice"

The Role of Lysosomes in a Broad Disease-Modifying Approach Evaluated across Transgenic Mouse Models of Alzheimer's Disease and Parkinson's Disease and Models of Mild Cognitive Impairment by Hwang, Jeannie, Estick, Candice M, Ikonne, Uzoma S, Butler, David, Pait, Morgan C, Elliott, Lyndsie H, Ruiz, Sarah, Smith, Kaitlan, Rentschler, Katherine M, Mundell, Cary, Almeida, Michael F, Stumbling Bear, Nicole, Locklear, James P, Abumohsen, Yara, Ivey, Cecily M, Farizatto, Karen L G, Bahr, Ben A

“…Many neurodegenerative disorders have lysosomal impediments, and the list of proposed treatments targeting lysosomes is growing. We investigated the role of…”
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Protective effects of positive lysosomal modulation in Alzheimer's disease transgenic mouse models by Butler, David, Hwang, Jeannie, Estick, Candice, Nishiyama, Akiko, Kumar, Saranya Santhosh, Baveghems, Clive, Young-Oxendine, Hollie B, Wisniewski, Meagan L, Charalambides, Ana, Bahr, Ben A

“…Alzheimer's disease (AD) is an age-related neurodegenerative pathology in which defects in proteolytic clearance of amyloid β peptide (Aβ) likely contribute to…”
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9. Potential combination therapies stemming from strategies against LSDs and PADs by Bahr, Ben A., Butler, David, Hwang, Jeannie, Estick, Candice

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Lysosomal modulation ameliorates Alzheimer‐type pathology: Evidence of protective cleavage of Aβ1‐42 by modulated cathepsins by Bahr, Ben A., Butler, David, Hwang, Jeannie, Estick, Candice, Nishiyama, Akiko, Kwon, Robert, Colon, Arthur, Charalambides, Ana

“…Abstract only Alzheimer's disease (AD) involves protein accumulation and progressive synaptic deterioration. Cathepsin proteases exhibit up‐regulation in…”
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Lysosomal Enhancement Promotes Synaptic Integrity and Functional Recovery in Mouse Models of Alzheimer's Disease by Butler, David, Estick, Candice, Batey, Lara, Hwang, Jeannie, Karim, Sanjida, Barnes, Sarah N., Manautou, Jose E., Bahr, Ban A.

“…Abstract only Reducing protein accumulation is essential for treating Alzheimer's disease (AD) by attenuating a pathogenic cascade that leads to synaptic…”
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