Search Results - "Estibeiro, Peter"

Microgels and apparatus for PAGE of nucleic acids in one or two dimensions by Thormar, Hans G, Gunnarsson, Gudmundur H, Gudmundsson, Bjarki, Leosson, Kristjan, Estibeiro, Peter, Jonsson, Jon J

“…We describe a system for horizontal 1D or 2D PAGE comprising an apparatus and microgels. There is no buffer outside the gel, making handling and sample loading…”
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The potential of antisense as a CNS therapeutic by Godfray, Jenny, Estibeiro, Peter

“…Antisense offers a precise and specific means of knocking down expression of a target gene, and is a major focus of research in neuroscience and other areas…”
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Enhanced long-term potentiation in the hippocampus of rats expressing mutant presenillin-1 is age related by Pybus, Ruth, Barnard, Eleanor, Estibeiro, Peter, Mullins, John, MacLeod, Nikki

“…Electrophysiological recordings were made from Fischer rats engineered to express the human presenilin 1 gene carrying the M146V mutation. Extracellular…”
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Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom : a systematic analysis of predisposing mutations and allelic variation in the PRNP gene by WINDL, O, DEMPSTER, M, PALMER, M. S, COLLINGE, J, ESTIBEIRO, J. P, LATHE, R, DE SILVA, R, ESMONDE, T, WILL, R, SPRINGBETT, A, CAMPBELL, T. A, SIDLE, K. C. L

“…Creutzfeldt-Jakob disease (CJD) is a transmissible neurodegenerative disorder characterized by the accumulation of aggregates of a cellular protein, PrP, in…”
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Interaction between splotch (Sp) and curly tail (ct) mouse mutants in the embryonic development of neural tube defects by ESTIBEIRO, J. P, BROOK, F. A, COPP, A. J

“…The mouse mutations splotch (Sp) and curly tail (ct) both produce spinal neural tube defects with closely similar morphology, but achieve this by different…”
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Impact of different ChIP-Seq protocols on DNA integrity and quality of bioinformatics analysis results by Felsani, Armando, Gudmundsson, Bjarki, Nanni, Simona, Brini, Elena, Moles, Anna, Thormar, Hans Guttormur, Estibeiro, Peter, Gaetano, Carlo, Capogrossi, Maurizio, Farsetti, Antonella, Jonsson, Jon Johannes, Guffanti, Alessandro

“…Different ChIP-Seq protocols may have a significant impact on the final outcome in terms of quality, number and distribution of called peaks. Sample DNA…”
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Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach by Morgan, Hugh P, Estibeiro, Peter, Wear, Martin A, Max, Klaas E.A, Heinemann, Udo, Cubeddu, Liza, Gallagher, Maurice P, Sadler, Peter J, Walkinshaw, Malcolm D

“…We have developed a novel DNA microarray-based approach for identification of the sequence-specificity of single-stranded nucleic-acid-binding proteins…”
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Comparative proteomic analysis using samples obtained with laser microdissection and saturation dye labelling by Wilson, Kate E., Marouga, Rita, Prime, John E., Pashby, D. Paul, Orange, Paul R., Crosier, Steven, Keith, Alexander B., Lathe, Richard, Mullins, John, Estibeiro, Peter, Bergling, Helene, Hawkins, Edward, Morris, Christopher M.

“…Comparative proteomic methods are rapidly being applied to many different biological systems including complex tissues. One pitfall of these methods is that in…”
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An endochitinase A from Vibrio carchariae: cloning, expression, mass and sequence analyses, and chitin hydrolysis by Suginta, Wipa, Vongsuwan, Archara, Songsiriritthigul, Chomphunuch, Prinz, Heino, Estibeiro, Peter, Duncan, Rory R, Svasti, Jisnuson, Fothergill-Gilmore, Linda A

“…We provide evidence that chitinase A from Vibrio carchariae acts as an endochitinase. The chitinase A gene isolated from V. carchariae genome encodes 850 amino…”
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Multiple roles for PrP in the prion diseases by Estibeiro, J. Peter

“…The pathology of transmissible spongiform encephalopathies (TSE) or prion diseases is characterized by spongiform degeneration of regions of the brain with…”
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Antisense as a neuroscience tool and therapeutic agent by Estibeiro, Peter, Godfray, Jenny

“…Gene expression in the mammalian brain is highly complex and requires an immensely powerful functional genomics tool to unravel it. Antisense has the potential…”
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The use of nucleic acid tools for target validation in central nervous system therapy by Godfray, Jenny, Fraser, Adrian, Page, David, Barnard, Eleanor, Estibeiro, Peter

“…The main challenge facing target validation today comes from the ongoing genomics revolution, which is generating an unprecedented number of potential targets…”
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The embryonic development of mammalian neural tube defects by Copp, A J, Brook, F A, Estibeiro, J P, Shum, A S, Cockroft, D L

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High-efficiency Semliki Forest virus-mediated transduction in bovine adrenal chromaffin cells by Duncan, R R, Don-Wauchope, A C, Tapechum, S, Shipston, M J, Chow, R H, Estibeiro, P

“…Adrenal chromaffin cells are commonly used in studies of exocytosis. Progress in characterizing the molecular mechanisms has been slow, because no simple,…”
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High-efficiency Semliki Forest virus-mediated transduction in bovine adrenal chromaffin cells by DUNCAN, Rory R., DON-WAUCHOPE, Andrew C., TAPECHUM, Sompol, SHIPSTON, Michael J., CHOW, Robert H., ESTIBEIRO, Peter

“…Adrenal chromaffin cells are commonly used in studies of exocytosis. Progress in characterizing the molecular mechanisms has been slow, because no simple,…”
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Neuritogenic-neurotoxic effects of membrane-associated forms of amyloid precursor protein by Neill, D, Hughes, D, Leake, A, Morris, C, Jones, D, Oakley, A, Edwardson, J, Estibeiro, P

“…The membrane-bound glycoprotein, amyloid precursor protein (APP), plays a central role in Alzheimer's disease (AD). The present paper investigates the…”
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Neuropathological phenotype and 'prion protein' genotype correlation in sporadic Creutzfeldt-Jakob disease by de Silva, R, Ironside, J W, McCardle, L, Esmonde, T, Bell, J, Will, R, Windl, O, Dempster, M, Estibeiro, P, Lathe, R

“…A systematic study of 'prion protein' genotype in cases of sporadic Creutzfeldt-Jakob disease showing amyloid plaques staining with anti-prion protein antibody…”
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Antisense as a neuroscience tool and therapeutic agent by Estibeiro, Peter, Godfray, Jenny

“…Gene expression in the mammalian brain is highly complex and requires an immensely powerful functional genomics tool to unravel it. Antisense has the potential…”
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Female predisposition to cranial neural tube defects is not because of a difference between the sexes in the rate of embryonic growth or development during neurulation by Brook, F A, Estibeiro, J P, Copp, A J

“…The susceptibility of females to anencephaly is well established and has been suggested to result from a slower rate of growth and development of female…”
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Exogenous transferrin is taken up and localized by the neurulation-stage mouse embryo in vitro by Copp, Andrew J., Estibeiro, J.Peter, Brook, Frances A., Downs, Karen M.

“…We have screened neurulation-stage mouse embryos for regional differences in protein distribution, by two-dimensional sodium dodecyl sulfate-polyacrylamide gel…”
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