Search Results - "Estes, Patricia S"

Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS by ESTES, Patricia S, BOEHRINGER, Ashley, ZWICK, Rebecca, TANG, Jonathan E, GRIGSBY, Brianna, ZARNESCU, Daniela C

“…The RNA-binding protein TDP-43 has been linked to amyotrophic lateral sclerosis (ALS) both as a causative locus and as a marker of pathology. With several…”
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Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis by Estes, Patricia S, Daniel, Scott G, McCallum, Abigail P, Boehringer, Ashley V, Sukhina, Alona S, Zwick, Rebecca A, Zarnescu, Daniela C

“…Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by complex neuronal and glial phenotypes. Recently, RNA-based mechanisms have been linked…”
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Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons by Estes, Patricia S., O’Shea, Michele, Clasen, Sara, Zarnescu, Daniela C.

“…Fragile X syndrome, the most common form of inherited mental retardation is caused by mutations in the FMR1 gene. FMR1 encodes an RNA-binding protein thought…”
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Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis by Coyne, Alyssa N, Siddegowda, Bhavani Bagevalu, Estes, Patricia S, Johannesmeyer, Jeffrey, Kovalik, Tina, Daniel, Scott G, Pearson, Antony, Bowser, Robert, Zarnescu, Daniela C

“…TDP-43 is an RNA-binding protein linked to amyotrophic lateral sclerosis (ALS) that is known to regulate the splicing, transport, and storage of specific mRNAs…”
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Nucleoside Diphosphate Kinase, a Source of GTP, Is Required for Dynamin-Dependent Synaptic Vesicle Recycling by Krishnan, K.S, Rikhy, Richa, Rao, Sujata, Shivalkar, Madhuri, Mosko, Michael, Narayanan, Radhakrishnan, Etter, Paul, Estes, Patricia S, Ramaswami, Mani

“…Nucleoside diphosphate kinase (NDK), an enzyme encoded by the Drosophila abnormal wing discs ( awd) or human nm23 tumor suppressor genes, generates nucleoside…”
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miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila by Daniel, Scott G, Russ, Atlantis D, Guthridge, Kathryn M, Raina, Ammad I, Estes, Patricia S, Parsons, Linda M, Richardson, Helena E, Schroeder, Joyce A, Zarnescu, Daniela C

“…( ) encodes a conserved tumor suppressor with established roles in cell polarity, asymmetric division, and proliferation control. Lgl's human orthologs, HUGL1…”
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PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43 by Joardar, Archi, Menzl, Judith, Podolsky, Taylor C, Manzo, Ernesto, Estes, Patricia S, Ashford, Sarah, Zarnescu, Daniela C

“…Amyotrophic Lateral Sclerosis (ALS) is a progressive neuromuscular disease for which there is no cure. We have previously developed a Drosophila model of ALS…”
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Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation by Coyne, Alyssa N, Yamada, Shizuka B, Siddegowda, Bhavani Bagevalu, Estes, Patricia S, Zaepfel, Benjamin L, Johannesmeyer, Jeffrey S, Lockwood, Donovan B, Pham, Linh T, Hart, Michael P, Cassel, Joel A, Freibaum, Brian, Boehringer, Ashley V, Taylor, J Paul, Reitz, Allen B, Gitler, Aaron D, Zarnescu, Daniela C

“…RNA dysregulation is a newly recognized disease mechanism in amyotrophic lateral sclerosis (ALS). Here we identify Drosophila fragile X mental retardation…”
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Staufen- and FMRP-Containing Neuronal RNPs Are Structurally and Functionally Related to Somatic P Bodies by Barbee, Scott A., Estes, Patricia S., Cziko, Anne-Marie, Hillebrand, Jens, Luedeman, Rene A., Coller, Jeff M., Johnson, Nick, Howlett, Iris C., Geng, Cuiyun, Ueda, Ryu, Brand, Andrea H., Newbury, Sarah F., Wilhelm, James E., Levine, Richard B., Nakamura, Akira, Parker, Roy, Ramaswami, Mani

“…Local control of mRNA translation modulates neuronal development, synaptic plasticity, and memory formation. A poorly understood aspect of this control is the…”
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Traffic of Dynamin within Individual Drosophila Synaptic Boutons Relative to Compartment-Specific Markers by Estes, Patricia S, Roos, Jack, van der Bliek, Alexander, Kelly, Regis B, Krishnan, K. S, Ramaswami, Mani

“…Presynaptic terminals contain several specialized compartments, which have been described by electron microscopy. We show in an identified Drosophila…”
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Drosophila Stoned Proteins Regulate the Rate and Fidelity of Synaptic Vesicle Internalization by Stimson, Daniel T, Estes, Patricia S, Rao, Sujata, Krishnan, K. S, Kelly, Leonard E, Ramaswami, Mani

“…At an initial step during synaptic vesicle recycling, dynamin and adaptor proteins mediate the endocytosis of synaptic vesicle components from the plasma…”
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Functional Dissection of a Eukaryotic Dicistronic Gene: Transgenic stonedB, but Not stonedA, Restores Normal Synaptic Properties to Drosophila stoned Mutants by Estes, Patricia S, Jackson, Taryn C, Stimson, Daniel T, Sanyal, Subhabrata, Kelly, Leonard E, Ramaswami, Mani

“…The dicistronic Drosophila stoned mRNA produces two proteins, stonedA and stonedB, that are localized at nerve terminals. While the stoned locus is required…”
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A Product of the Drosophila stoned Locus Regulates Neurotransmitter Release by Stimson, Daniel T, Estes, Patricia S, Smith, Michiko, Kelly, Leonard E, Ramaswami, Mani

“…The Drosophila stoned locus encodes two novel gene products termed stonedA and stonedB, which possess sequence motifs shared by proteins involved in…”
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Atrazine uptake, photosynthetic inhibition, and short-term recovery for the submersed vascular plant, Potamogeton perfoliatus L by Jones, T.W, Kemp, W.M, Estes, P.S, Stevenson, J.C

“…P. perfoliatus were exposed to atrazine (10, 50, 100, 450, 650 ug per litre) for up to 24 h. Uptake and release of atrazine was rapid, reaching equilibrium…”
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Synaptic Localization and Restricted Diffusion of a Drosophila Neuronal Synaptobrevin - Green Fluorescent Protein Chimera in Vivo by Estes, Patricia S., Ho, Grace L.Y., Narayanan, Radhakrishnan, Ramaswami, Mani

“…Fluorescent markers for subcellular compartments in Drosophila neurons should allow one to combine genetic mutant analysis with visualization of subcellular…”
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Traffic of Dynamin within Individual DrosophilaSynaptic Boutons Relative to Compartment-Specific Markers by Estes, Patricia S., Roos, Jack, van der Bliek, Alexander, Kelly, Regis B., Krishnan, K. S., Ramaswami, Mani

“…Presynaptic terminals contain several specialized compartments, which have been described by electron microscopy. We show in an identified Drosophila…”
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A method for the direct measurement of mRNA in discrete regions of mammalian brain by Melloni, Jr, R H, Estes, P S, Howland, D S, DeGennaro, L J

“…A rapid and nearly quantitative method for the direct analysis of steady-state mRNA levels in microgram quantities of frozen mammalian brain is described…”
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Positive- and negative-acting promoter sequences regulate cell type-specific expression of the rat synapsin I gene by Howland, D S, Hemmendinger, L M, Carroll, P D, Estes, P S, Melloni, Jr, R H, DeGennaro, L J

“…The phosphoprotein synapsin I is expressed exclusively in neuronal cells. We are interested in elucidating the promoter sequences involved in cell…”
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