Search Results - "Esteoulle, Lucie"
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A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia
Published in Nature communications (12-01-2021)“…Apelin and arginine-vasopressin (AVP) are conversely regulated by osmotic stimuli. We therefore hypothesized that activating the apelin receptor (apelin-R)…”
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Development of original metabolically stable apelin‐17 analogs with diuretic and cardiovascular effects
Published in The FASEB journal (01-02-2017)“…ABSTRACT Apelin, a (neuro)vasoactive peptide, plays a prominent role in controlling cardiovascular functions and water balance. Because the in vivo apelin…”
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LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism
Published in Frontiers in pharmacology (26-07-2021)“…Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and water balance, but has an in-vivo half-life in the…”
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e-Health: A Future Solution for Optimized Management of Elderly Patients. GER-e-TEC™ Project
Published in Medicines (Basel, Switzerland) (23-07-2020)“…Elderly residents in nursing homes have multiple comorbidities (including cognitive and psycho-behavioral pathologies, malnutrition, heart failure, diabetes,…”
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A near-infrared fluorogenic dimer enables background-free imaging of endogenous GPCRs in living mice
Published in Chemical science (Cambridge) (14-07-2020)“…Fluorescent probes are commonly used in studying G protein-coupled receptors in living cells; however their application to the whole animal receptor imaging is…”
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Self‐organization Properties of a GPCR‐Binding Peptide with a Fluorinated Tail Studied by Fluorine NMR Spectroscopy
Published in Chembiochem : a European journal of chemical biology (15-02-2021)“…Conjugation of the bioactive apelin‐17 peptide with a fluorocarbon chain results in self‐organization of the peptide into micelles. Fluorine NMR spectroscopy…”
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Activating the apelin receptor with LIT01-196, a metabolically stable apelin analog, reverses AVP-induced antidiuresis and hyponatremia
Published in Nature communications (12-01-2021)“…Abstract Apelin and arginine-vasopressin (AVP) are conversely regulated by osmotic stimuli. We therefore hypothesized that activating the apelin receptor…”
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Journal Article -
8
LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism
Published 08-11-2022“…Frontiers in Pharmacology, Frontiers, 2021, 12 Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and…”
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Journal Article