Synergistic interaction between B vitamins and statins to counter nociception in rats

Synergistic interaction between B vitamins and statins to counter nociception in rats

Evidence suggests that the antinociceptive activity of various drugs can be increased when administered in combination with B vitamins (BVs). The aim of this study was to examine the potential interaction between statins and BVs to counter nociception, the latter measured by the formalin test. Rats...

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Published in:Drug development research Vol. 82; no. 3; pp. 440 - 447
Main Authors: Skiold, López‐Canales Jorge, Estefania, Ruiz‐Pedraza Paola, Carolina, García‐Paz María Paola, Mery, López‐Mayorga Ruth, Fernando, Castillo‐Henkel Enrique, Jair, Lozano‐Cuenca
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01-05-2021
Wiley Subscription Services, Inc
Subjects:
analgesia
Animals
Atorvastatin
B vitamins
Drug Synergism
formalin test
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
isobolographic analysis
Male
Mathematical analysis
Nociception - drug effects
Oral administration
Pain
Pain Measurement
Pain perception
pharmacology
Pravastatin
Rats
Rats, Wistar
Statins
Vitamin B Complex - pharmacology
Vitamins
pain
statins
analgesia
pharmacology
isobolographic analysis
B vitamins
formalin test
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Summary:Evidence suggests that the antinociceptive activity of various drugs can be increased when administered in combination with B vitamins (BVs). The aim of this study was to examine the potential interaction between statins and BVs to counter nociception, the latter measured by the formalin test. Rats were orally administered atorvastatin (1, 3, 10 and 30 mg/kg), pravastatin (1, 3, 10 and 30 mg/kg), rosuvastatin (1, 3, 10 and 30 mg/kg), BVs (31, 56, 100 and 180 mg/kg) or calculated combinations of BVs with each drug. The effective dose 30 (ED30) was calculated for each statin and BVs and subjected to isobolographic analysis, thus finding the ED30 of the combinations. The antinociceptive experimental ED30 values for BVs administered with atorvastatin, pravastatin or rosuvastatin were 1.53 ± 0.38, 6.74 ± 0.04 and 4.26 ± 0.39, respectively, being lower (p < .05) than the corresponding theoretical ED30: 28.02 ± 2.20, 28.17 ± 2.20 and 29.86 ± 2.21. Since BVs likely boost the antinociceptive effect of statins, these combinations could possibly be advantageous in pain management.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0272-4391
1098-2299
DOI:10.1002/ddr.21767