Search Results - "Este, Jose A"

Secretion of interferon-γ by human macrophages demonstrated at the single-cell level after costimulation with interleukin (IL)-12 plus IL-18 by Darwich, Laila, Coma, Gemma, Peña, Ruth, Bellido, Rocio, Blanco, Ester J.J, Este, José A, Borras, Francesc E, Clotet, Bonaventura, Ruiz, Lidia, Rosell, Antoni, Andreo, Felipe, Parkhouse, R. Michael E, Bofill, Margarita

“…The interferon (IFN)-γ component of the immune response plays an essential role in combating infectious and non-infectious diseases. Induction of IFN-γ…”
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Antiretroviral Agents Effectively Block HIV Replication after Cell-to-Cell Transfer by PERMANYER, Marc, BALLANA, Ester, RUIZ, Alba, BADIA, Roger, RIVEIRA-MUNOZ, Eva, GONZALO, Encarna, CLOTET, Bonaventura, ESTE, Jose A

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p21 regulates the HIV-1 restriction factor SAMHD1 by Pauls, Eduardo, Ruiz, Alba, Riveira-Muñoz, Eva, Permanyer, Marc, Badia, Roger, Clotet, Bonaventura, Keppler, Oliver T, Ballana, Ester, Este, Jose A

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Role of the Human Immunodeficiency Virus Type 1 Envelope Gene in Viral Fitness by Rangel, Hector R, Weber, Jan, Chakraborty, Bikram, Gutierrez, Arantxa, Marotta, Michael L, Mirza, Muneer, Kiser, Patti, Martinez, Miguel A, Este, Jose A, Quiñones-Mateu, Miguel E

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SAMHD1 Specifically Affects the Antiviral Potency of Thymidine Analog HIV Reverse Transcriptase Inhibitors by BALLANA, Ester, BADIA, Roger, TERRADAS, Gerard, TORRES-TORRONTERAS, Javier, RUIZ, Alba, PAULS, Eduardo, RIVEIRA-MUNOZ, Eva, CLOTET, Bonaventura, MARTI, Ramon, ESTE, José A

“…Sterile alpha motif and histidine-aspartic domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase recently…”
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Discovery of Chiral Cyclopropyl Dihydro-Alkylthio-Benzyl-Oxopyrimidine (S-DABO) Derivatives as Potent HIV-1 Reverse Transcriptase Inhibitors with High Activity Against Clinically Relevant Mutants by Radi, Marco, Maga, Giovanni, Alongi, Maddalena, Angeli, Lucilla, Samuele, Alberta, Zanoli, Samantha, Bellucci, Luca, Tafi, Andrea, Casaluce, Gianni, Giorgi, Gianluca, Armand-Ugon, Mercedes, Gonzalez, Emmanuel, Esté, José A, Baltzinger, Mireille, Bec, Guillaume, Dumas, Philippe, Ennifar, Eric, Botta, Maurizio

“…The role played by stereochemistry in the C2-substituent (left part) on the S-DABO scaffold for anti-HIV-1 activity has been investigated for the first time. A…”
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ZNRD1 (Zinc Ribbon Domain-Containing 1) Is a Host Cellular Factor That Influences HIV-1 Replication and Disease Progression by Ballana, Ester, Senserrich, Jordi, Pauls, Eduardo, Faner, Rosa, Mercader, Josep Maria, Uyttebroeck, Frédéric, Palou, Eduard, Mena, Maria Pau, Grau, Eulalia, Clotet, Bonaventura, Ruiz, Lidia, Telenti, Amalio, Ciuffi, Angela, Esté, José A.

“…Background Human immunodeficiency virus (HIV) takes advantage of multiple host proteins to support its own replication. The gene ZNRD1 (zinc ribbon…”
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Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication by MARTINEZ, Miguel A, GUTIERREZ, Arantxa, ARMAND-UGON, Mercedes, BLANCO, Julia, PARERA, Mariona, GOMEZ, Jordi, CLOTET, Bonaventura, ESTE, José A

“…Duplexes of 21 base pair RNA, known as short-interfering RNA (siRNA), have been shown to inhibit gene expression by a sequence-specific RNA degradation…”
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β5 Integrin Is the Major Contributor to the αv Integrin-Mediated Blockade of HIV-1 Replication by Ballana, Ester, Pauls, Eduardo, Clotet, Bonaventura, Perron-Sierra, Françoise, Tucker, Gordon C., Esté, José A.

“…Monocytes and macrophages are targets of HIV-1 infection and play critical roles in multiple aspects of viral pathogenesis. During the differentiation of…”
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Cell adhesion through αV-containing integrins is required for efficient HIV-1 infection in macrophages by Ballana, Ester, Pauls, Eduardo, Senserrich, Jordi, Clotet, Bonaventura, Perron-Sierra, Françoise, Tucker, Gordon C., Esté, José A.

“…Monocytes and macrophages are an important reservoir of human immunodeficiency virus (HIV) and may represent the largest reservoir of this virus in tissues…”
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Synthesis and Biological Properties of Novel 2-Aminopyrimidin-4(3H)-ones Highly Potent against HIV-1 Mutant Strains by Mai, Antonello, Artico, Marino, Rotili, Dante, Tarantino, Domenico, Clotet-Codina, Imma, Armand-Ugón, Mercedes, Ragno, Rino, Simeoni, Silvia, Sbardella, Gianluca, Nawrozkij, Maxim B, Samuele, Alberta, Maga, Giovanni, Esté, José A

“…Following the disclosure of dihydro-alkoxy-, dihydro-alkylthio-, and dihydro-alkylamino-benzyl-oxopyrimidines (DABOs, S-DABOs, and NH-DABOs) as potent and…”
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Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors by Puig-de-la-Bellacasa, Raimon, Giménez, Laura, Pettersson, Sofia, Pascual, Rosalia, Gonzalo, Encarna, Esté, José A., Clotet, Bonaventura, Borrell, José I., Teixidó, Jordi

“…New analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) were synthesized and evaluated for their in vitro activities against HIV-1 in MT-4…”
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SAMHD1: At the Crossroads of Cell Proliferation, Immune Responses, and Virus Restriction by Ballana, Ester, Esté, José A

“…SAMHD1 is a triphosphohydrolase enzyme that controls the intracellular level of deoxyribonucleoside triphosphates (dNTPs) and plays a role in innate immune…”
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Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants by Mugnaini, Claudia, Alongi, Maddalena, Togninelli, Andrea, Gevariya, Harsukh, Brizzi, Antonella, Manetti, Fabrizio, Bernardini, Cesare, Angeli, Lucilla, Tafi, Andrea, Bellucci, Luca, Corelli, Federico, Massa, Silvio, Maga, Giovanni, Samuele, Alberta, Facchini, Marcella, Clotet-Codina, Imma, Armand-Ugón, Mercedes, Esté, José A, Botta, Maurizio

“…A series of novel S-DABO analogues, characterized by different substitution patterns at positions 2, 5, and 6 of the heterocyclic ring, were synthesized in a…”
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Different selection patterns of resistance and cross-resistance to HIV-1 agents targeting CCR5 by Armand-Ugón, Mercedes, Moncunill, Gemma, Gonzalez, Emmanuel, Mena, MariaPau, Ballana, Ester, Clotet, Bonaventura, Esté, José A.

“…Objectives Identification of CCR5 as an antiretroviral target led to the development of several CCR5 antagonists in clinical trials and the approval of…”
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A clathrin–dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell–T cell transmission by Bosch, Berta, Grigorov, Boyan, Senserrich, Jordi, Clotet, Bonaventura, Darlix, Jean-Luc, Muriaux, Delphine, Este, José A.

“…Cellular contacts between HIV-1-infected cells and target primary T CD4+ lymphocytes trigger the formation of a structure known as the virological synapse. As…”
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Current status and challenges of antiretroviral research and therapy by Esté, José A., Cihlar, Tomas

“…Twenty-five years after the discovery of the therapeutic activity of azidothymidine (AZT), the first antiretroviral drug used in the clinic, infection with the…”
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HIV endocytosis after dendritic cell to T cell viral transfer leads to productive virus infection by Clotet-Codina, Imma, Bosch, Berta, Senserrich, Jordi, Fernández-Figueras, María Teresa, Peña, Ruth, Ballana, Ester, Bofill, Margarita, Clotet, Bonaventura, Esté, José A.

“…Contacts between HIV-producing T cells and primary CD4+ T cells may induce the uptake of HIV by target cells that are endocytosed into trypsin-resistant…”
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Applications of 3-aminolactams: design, synthesis, and biological evaluation of a library of potential dimerisation inhibitors of HIV1-protease by Pinyol, Eulàlia, Frutos, Silvia, Grillo-Bosch, Dolors, Giralt, Ernest, Clotet, Bonaventura, Esté, Jose A, Diez, Anna

“…In the context of our studies on the applications of 3-aminolactams as conformationally restricted pseudodipeptides, we report here the synthesis of a library…”
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Inhibition of HIV-1 replication by RNA interference of p53 expression by Pauls, Eduardo, Senserrich, Jordi, Clotet, Bonaventura, Esté, Jose A.

“…p53 expression and activation have been associated to faster human immunodeficiency virus (HIV) disease progression, most probably by inducing CD4+ T cell…”
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