Search Results - "Estaña, Alejandro"

Realistic Ensemble Models of Intrinsically Disordered Proteins Using a Structure-Encoding Coil Database by Estaña, Alejandro, Sibille, Nathalie, Delaforge, Elise, Vaisset, Marc, Cortés, Juan, Bernadó, Pau

“…Intrinsically disordered proteins (IDPs) play fundamental roles in signaling, regulation, and cell homeostasis by specifically interacting with their partners…”
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Small-angle scattering studies of intrinsically disordered proteins and their complexes by Cordeiro, Tiago N, Herranz-Trillo, Fátima, Urbanek, Annika, Estaña, Alejandro, Cortés, Juan, Sibille, Nathalie, Bernadó, Pau

“…[Display omitted] •Despite the absence of permanent structure, IDPs perform crucial functions in biology.•Structural studies of IDPs require the combination of…”
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Evidence of the Reduced Abundance of Proline cis Conformation in Protein Poly Proline Tracts by Urbanek, Annika, Popovic, Matija, Elena-Real, Carlos A, Morató, Anna, Estaña, Alejandro, Fournet, Aurélie, Allemand, Frédéric, Gil, Ana M, Cativiela, Carlos, Cortés, Juan, Jiménez, Ana I, Sibille, Nathalie, Bernadó, Pau

“…Proline is found in a cis conformation in proteins more often than other proteinogenic amino acids, where it influences structure and modulates function, being…”
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Predicting Secondary Structure Propensities in IDPs Using Simple Statistics from Three-Residue Fragments by Estaña, Alejandro, Barozet, Amélie, Mouhand, Assia, Vaisset, Marc, Zanon, Christophe, Fauret, Pierre, Sibille, Nathalie, Bernadó, Pau, Cortés, Juan

“…Intrinsically disordered proteins (IDPs) play key functional roles facilitated by their inherent plasticity. In most of the cases, IDPs recognize their…”
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Investigating the Formation of Structural Elements in Proteins Using Local Sequence-Dependent Information and a Heuristic Search Algorithm by Estaña, Alejandro, Ghallab, Malik, Bernadó, Pau, Cortés, Juan

“…Structural elements inserted in proteins are essential to define folding/unfolding mechanisms and partner recognition events governing signaling processes in…”
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Conformational buffering underlies functional selection in intrinsically disordered protein regions by González-Foutel, Nicolás S., Glavina, Juliana, Borcherds, Wade M., Safranchik, Matías, Barrera-Vilarmau, Susana, Sagar, Amin, Estaña, Alejandro, Barozet, Amelie, Garrone, Nicolás A., Fernandez-Ballester, Gregorio, Blanes-Mira, Clara, Sánchez, Ignacio E., de Prat-Gay, Gonzalo, Cortés, Juan, Bernadó, Pau, Pappu, Rohit V., Holehouse, Alex S., Daughdrill, Gary W., Chemes, Lucía B.

“…Many disordered proteins conserve essential functions in the face of extensive sequence variation, making it challenging to identify the mechanisms responsible…”
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Flanking Regions Determine the Structure of the Poly-Glutamine in Huntingtin through Mechanisms Common among Glutamine-Rich Human Proteins by Urbanek, Annika, Popovic, Matija, Morató, Anna, Estaña, Alejandro, Elena-Real, Carlos A., Mier, Pablo, Fournet, Aurélie, Allemand, Frédéric, Delbecq, Stephane, Andrade-Navarro, Miguel A., Cortés, Juan, Sibille, Nathalie, Bernadó, Pau

“…The causative agent of Huntington's disease, the poly-Q homo-repeat in the N-terminal region of huntingtin (httex1), is flanked by a 17-residue-long fragment…”
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Interdomain linkers tailor the stability of immunoglobulin repeats in polyproteins by Joshi, Tanuja, Garg, Surbhi, Estaña, Alejandro, Cortés, Juan, Bernadó, Pau, Das, Sayan, Kammath, Anjana R., Sagar, Amin, Rakshit, Sabyasachi

“…Linkers in polyproteins are considered as mere spacers between two adjacent domains. However, a series of studies using single-molecule force spectroscopy have…”
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The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity by Elena-Real, Carlos A., Sagar, Amin, Urbanek, Annika, Popovic, Matija, Morató, Anna, Estaña, Alejandro, Fournet, Aurélie, Doucet, Christine, Lund, Xamuel L., Shi, Zhen-Dan, Costa, Luca, Thureau, Aurélien, Allemand, Frédéric, Swenson, Rolf E., Milhiet, Pierre-Emmanuel, Crehuet, Ramon, Barducci, Alessandro, Cortés, Juan, Sinnaeve, Davy, Sibille, Nathalie, Bernadó, Pau

“…Huntington’s disease is a neurodegenerative disorder caused by a CAG expansion in the first exon of the HTT gene, resulting in an extended polyglutamine…”
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Multi-site-specific isotopic labeling accelerates high-resolution structural investigations of pathogenic huntingtin exon-1 by Elena-Real, Carlos A., Urbanek, Annika, Lund, Xamuel L., Morató, Anna, Sagar, Amin, Fournet, Aurélie, Estaña, Alejandro, Bellande, Tracy, Allemand, Frédéric, Cortés, Juan, Sibille, Nathalie, Melki, Ronald, Bernadó, Pau

“…Huntington’s disease neurodegeneration occurs when the number of consecutive glutamines in the huntingtin exon-1 (HTTExon1) exceeds a pathological threshold of…”
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Hybrid parallelization of a multi-tree path search algorithm: Application to highly-flexible biomolecules by Estaña, Alejandro, Molloy, Kevin, Vaisset, Marc, Sibille, Nathalie, Siméon, Thierry, Bernadó, Pau, Cortés, Juan

“…•A new strategy to parallelize a randomized path planning algorithm is proposed.•Our hybrid approach exploits both multithreading and message-passing…”
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Flanking regions determine the structure of the poly-glutamine homo- repeat in huntingtin through mechanisms common among glutamine-rich human proteins by Urbanek, Annika N, Popovic, Matija, Morató, Anna, Estaña, Alejandro N, Elena-Real, Carlos A, Mier, Pablo, Fournet, Aurélie, Allemand, Frédéric, Delbecq, Stéphane, Andrade-Navarro, Miguel A, Cortés, Juan, Sibille, Nathalie, Bernadó, Pau N

“…The causative agent of Huntington's disease, the poly-Q homo-repeat in the N-terminal region of huntingtin (httex1), is flanked by a 17-residue-long fragment…”
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Small-angle scattering studies of intrinsically disordered proteins and their complexes by Cordeiro, Tiago, Herranz-Trillo, Fatima, Urbanek, Annika, Estaña, Alejandro, Cortés, Juan, Sibille, Nathalie, Bernadó, Pau

“…Current Opinion in Structural Biology, Elsevier, 2017, 42, pp.15 - 23 Intrinsically Disordered Proteins (IDPs) perform a broad range of biological functions…”
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