Search Results - "Estabrook, R. August"

Specific and sensitive detection of nucleic acids and RNases using gold nanoparticle-RNA-fluorescent dye conjugates by Kim, Joong H, Estabrook, R August, Braun, Gary, Lee, Briana R, Reich, Norbert O

“…Gold nanoparticles were modified with RNA and utilized to detect specific DNA sequences and various RNA nucleases…”
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Observing an Induced-fit Mechanism during Sequence-specific DNA Methylation by Estabrook, R.August, Reich, Norbert

“…The characterization of conformational changes that drive induced-fit mechanisms and their quantitative importance to enzyme specificity are essential for a…”
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Coupling Sequence-specific Recognition to DNA Modification by Estabrook, R. August, Nguyen, Trung T., Fera, Nickolas, Reich, Norbert O.

“…Enzymes that modify DNA are faced with significant challenges in specificity for both substrate binding and catalysis. We describe how single hydrogen bonds…”
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Statistical Coevolution Analysis and Molecular Dynamics: Identification of Amino Acid Pairs Essential for Catalysis by Estabrook, R. August, Luo, Jia, Purdy, Matthew M., Sharma, Vyas, Weakliem, Paul, Bruice, Thomas C., Reich, Norbert O.

“…Molecular dynamics (MD) simulations of Hhal DNA methyltransferase and statistical coupling analysis (SCA) data on the DNA cytosine methyltransferase family…”
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Functional Characterization of Escherichia coli DNA Adenine Methyltransferase, a Novel Target for Antibiotics by Mashhoon, Neda, Carroll, Michael, Pruss, Cynthia, Eberhard, Joerg, Ishikawa, Sawako, Estabrook, R August, Reich, Norbert

“…We have characterized Escherichia coli DNA adenine methyltransferase, a critical regulator of bacterial virulence. Steady-state kinetics, product inhibition,…”
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The coupling of tight DNA binding and base flipping: identification of a conserved structural motif in base flipping enzymes by Estabrook, R August, Lipson, Rebecca, Hopkins, Ben, Reich, Norbert

“…Val(121) is positioned immediately above the extrahelical cytosine in HhaI DNA C(5)-cytosine methyltransferase, and replacement with alanine dramatically…”
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Molecular Scale Architecture: Engineered Three- And Four-Way Junctions by Wilkinson, Stephanie, Diechtierow, Michael, Estabrook, R. August, Schmidt, Falk, Hüben, Michael, Weinhold, Elmar, Reich, Norbert O

“…Biomolecular self-assembly provides a basis for the bottom-up construction of useful and diverse nanoscale architectures. DNA is commonly used to create these…”
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Gold Nanoparticle Decoration of DNA on Silicon by Braun, Gary, Inagaki, Katsuhiko, Estabrook, R. August, Wood, D. K, Levy, Eran, Cleland, A. N, Strouse, Geoffrey F, Reich, Norbert O

“…Electrostatic assembly of cationic nanoparticles onto the negatively charged backbone of double-stranded DNA has been shown to produce one-dimensional chains…”
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The Coupling of Tight DNA Binding and Base Flipping by Estabrook, R. August, Lipson, Rebecca, Hopkins, Ben, Reich, Norbert

“…Val 121 is positioned immediately above the extrahelical cytosine in HhaI DNA C 5 -cytosine methyltransferase, and replacement with alanine dramatically…”
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Dynamic aspects of DNA methylation in M.HhaI by Estabrook, R August

“…DNA methylation is ubiquitous and essential to life. In order to further our understanding of DNA methylation, facilitate drug discovery, and to elucidate…”
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Dynamic aspects of DNA methylation in M.HhaI by Estabrook, R. August

“…DNA methylation is ubiquitous and essential to life. In order to further our understanding of DNA methylation, facilitate drug discovery, and to elucidate…”
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