Search Results - "Esté, J A"

Treatment of monocytes with interleukin (IL)‐12 plus IL‐18 stimulates survival, differentiation and the production of CXC chemokine ligands (CXCL)8, CXCL9 and CXCL10 by Coma, G., Peña, R., Blanco, J., Rosell, A., Borras, F. E., Esté, J. A., Clotet, B., Ruiz, L., Parkhouse, R. M. E., Bofill, M.

“…Summary During inflammation, interleukin (IL)‐12 and IL‐18 are produced by macrophages and other cell types such as neutrophils (IL‐12), keratinocytes and…”
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CXCR4 and SDF-1 expression in B-cell chronic lymphocytic leukemia and stage of the disease by BARRETINA, J, JUNCA, J, LLANO, A, GUTIERREZ, A, FLORES, A, BLANCO, J, CLOTET, B, ESTE, J. A

“…The pathogenesis of B-cell chronic lymphocytic leukemia (B-CLL) has been linked to an overexpression of the chemokine receptor CXCR4 and increased in vitro…”
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Interleukin-7 in Plasma Correlates with CD4 T-Cell Depletion and May Be Associated with Emergence of Syncytium-Inducing Variants in Human Immunodeficiency Virus Type 1-Positive Individuals by Llano, A, Barretina, J, Gutiérrez, A, Blanco, J, Cabrera, C, Clotet, B, Esté, J A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor Fusin/CXCR-4 by Schols, Dominique, Esté, José A, Henson, Geoffrey, De Clercq, Erik

“…Bicyclams are a novel class of antiviral compounds which are highly potent and selective inhibitors of the replication of HIV-1 and HIV-2. The prototype…”
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The implication of the chemokine receptor CXCR4 in HIV-1 envelope protein-induced apoptosis is independent of the G protein-mediated signalling by BLANCO, J, JACOTOT, E, CABRERA, C, CARDONA, A, CLOTET, B, DE CLERCQ, E, ESTE, J. A

“…The envelope glycoprotein complex (gp120/gp41)n of HIV-1 is one of the viral products responsible for increased apoptosis in HIV infection. Here the role of…”
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The CXCR4 Antagonist AMD3100 Efficiently Inhibits Cell-Surface-Expressed Human Immunodeficiency Virus Type 1 Envelope-Induced Apoptosis by BLANCO, J, BARRETINA, J, HENSON, G, BRIDGER, G, DE CLERCQ, E, CLOTET, B, ESTE, J. A

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SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus by WITVROUW, M, BALZARINI, J, DESMYTER, J, RAMADAS, S. R, DE CLERCQ, E, PANNECOUQUE, C, JHAUMEER-LAULLOO, S, ESTE, J. A, SCHOLS, D, CHEREPANOV, P, SCHMIT, J.-C, DEBYSER, Z, VANDAMME, A.-M

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Application of the EIIP/ISM bioinformatics concept in development of new drugs by Veljkovic, V, Veljkovic, N, Esté, J A, Hüther, A, Dietrich, U

“…The development of a new therapeutic drug is a complex, lengthy and expensive process. On average, only one out of 10,000 - 30,000 originally synthesized…”
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Recent advances in combinatorial chemistry applied to development of anti-HIV drugs by Pettersson, S, Clotet-Codina, I, Esté, J A, Borrell, J I, Teixidó, J

“…A compilation of combinatorial chemistry techniques applied to anti-HIV drug development is presented in this review. This synthetic strategy together with…”
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Anti-human immunodeficiency virus activity of novel aminoglycoside-arginine conjugates at early stages of infection by Cabrera, C, Gutiérrez, A, Blanco, J, Barretina, J, Litovchick, A, Lapidot, A, Evdokimov, A G, Clotet, B, Esté, J A

“…Conjugates of L-arginine with aminoglycosides have already been described as potent in vitro inhibitors of the HIV-1 Tat-trans-activation responsive element…”
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Stromal-cell-derived factor 1 prevents the emergence of the syncytium-inducing phenotype of HIV-1 in vivo by LLANO, Anuska, BARRETINA, Jordi, BLANCO, Julia, GUTIERREZ, Arantxa, CLOTET, Bonaventura, ESTE, José A

“…In a correlative study, the mean plasma level of the chemokine stromal-cell-derived factor 1 (SDF-1) was lower in subjects with syncytium-inducing (SI) than in…”
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A Bacteriophage Lambda-Based Genetic Screen for Characterization of the Activity and Phenotype of the Human Immunodeficiency Virus Type 1 Protease by MARTINEZ, M.-A, CABANA, M, PARERA, M, GUTIERREZ, A, ESTE, J. A, CLOTET, B

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Chemokine and chemokine receptor expression after combined anti-HIV-1 interleukin-2 therapy by BLANCO, J, CABRERA, C, JOU, A, RUIZ, L, CLOTET, B, ESTE, J. A

“…To evaluate changes in serum levels of chemokines, chemokine production, and chemokine receptor expression by peripheral blood mononuclear cells (PBMC), after…”
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Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4 by Schols, D, Struyf, S, Van Damme, J, Esté, J A, Henson, G, De Clercq, E

“…Bicyclams are a novel class of antiviral compounds that are highly potent and selective inhibitors of the replication of HIV-1 and HIV-2. Surprisingly,…”
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AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor by Donzella, George A, Schols, Dominique, Lin, Steven W, Esté, José A, Nagashima, Kirsten A, Maddon, Paul J, Allaway, Graham P, Sakmar, Thomas P, Henson, Geoffrey, DeClercq, Erik, Moore, John P

“…The bicyclam AMD3100 (formula weight 830) blocks HIV-1 entry and membrane fusion via the CXCR4 co-receptor, but not via CCR5. AMD3100 prevents monoclonal…”
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Ajoene [(e,z)-4,5,9-trithiadodeca-1, 6, 11-triene 9 oxide] does not exhibit antiviral activity at subtoxic concentrations by Esté, JA, De Clercq, E

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Induction of interleukins IL‐6 and IL‐8 by siRNA by Pauls, E., Senserrich, J., Bofill, M., Clotet, B., Esté, J. A.

“…Summary The HIV‐1 co‐receptor CCR5 has been thought a relevant target for small interfering RNA (siRNA)‐based therapeutics. However, recent findings suggest…”
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Anti-HIV-1 Activity of Combinations and Covalent Conjugates of Negatively Charged Human Serum Albumins (NCAs) and AZT by Kuipers, M. E., Swart, P. J., Witvrouw, M., Esté, J. A., Reymen, D., Clercq, E. De, Meijer, D. K. F.

“…Abstract Negatively charged albumins (NCAs, with the prototypes Suc-HSA and Aco-HSA), modified proteins with a potent anti-HIV-1 activity in the nanomolar…”
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Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases by Ferri, K F, Jacotot, E, Blanco, J, Esté, J A, Zamzami, N, Susin, S A, Xie, Z, Brothers, G, Reed, J C, Penninger, J M, Kroemer, G

“…Syncytia arising from the fusion of cells expressing a lymphotropic HIV type 1-encoded envelope glycoprotein complex (Env) with cells expressing the CD4/CXC…”
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Evaluation of the putative role of C-C chemokines as protective factors of HIV-1 infection in seronegative hemophiliacs exposed to contaminated hemoderivatives by Barretina, J., Blanco, J., Gutiérrez, A., Puig, L., Altisent, C., Espanol, T., Caragol, I., Clotet, B., Esté, J.A.

“…BACKGROUND: Overproduction of β‐chemokines and genetic variations in chemokine receptors have been correlated with protection against infection by HIV‐1 or…”
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