Search Results - "Esswein, Shannon R."

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies by Barnes, Christopher O., Jette, Claudia A., Abernathy, Morgan E., Dam, Kim-Marie A., Esswein, Shannon R., Gristick, Harry B., Malyutin, Andrey G., Sharaf, Naima G., Huey-Tubman, Kathryn E., Lee, Yu E., Robbiani, Davide F., Nussenzweig, Michel C., West, Anthony P., Bjorkman, Pamela J.

“…The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding…”
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Formation of Amyloid Fibers by Monomeric Light Chain Variable Domains by Brumshtein, Boris, Esswein, Shannon R., Landau, Meytal, Ryan, Christopher M., Whitelegge, Julian P., Phillips, Martin L., Cascio, Duilio, Sawaya, Michael R., Eisenberg, David S.

“…Systemic light chain amyloidosis is a lethal disease characterized by excess immunoglobulin light chains and light chain fragments composed of variable…”
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How Antibodies Recognize Pathogenic Viruses: Structural Correlates of Antibody Neutralization of HIV-1, SARS-CoV-2, and Zika by Abernathy, Morgan E, Dam, Kim-Marie A, Esswein, Shannon R, Jette, Claudia A, Bjorkman, Pamela J

“…The H1N1 pandemic of 2009-2010, MERS epidemic of 2012, Ebola epidemics of 2013-2016 and 2018-2020, Zika epidemic of 2015-2016, and COVID-19 pandemic of…”
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Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain by Brumshtein, Boris, Esswein, Shannon R, Salwinski, Lukasz, Phillips, Martin L, Ly, Alan T, Cascio, Duilio, Sawaya, Michael R, Eisenberg, David S

“…Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients'…”
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Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis by Brumshtein, Boris, Esswein, Shannon R., Sawaya, Michael R., Rosenberg, Gregory, Ly, Alan T., Landau, Meytal, Eisenberg, David S.

“…Systemic light-chain amyloidosis (AL) is a human disease caused by overexpression of monoclonal immunoglobulin light chains that form pathogenic amyloid…”
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Author Correction: SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies by Barnes, Christopher O., Jette, Claudia A., Abernathy, Morgan E., Dam, Kim-Marie A., Esswein, Shannon R., Gristick, Harry B., Malyutin, Andrey G., Sharaf, Naima G., Huey-Tubman, Kathryn E., Lee, Yu E., Robbiani, Davide F., Nussenzweig, Michel C., West, Anthony P., Bjorkman, Pamela J.

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A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques by Van Rompay, Koen K. A., Coffey, Lark L., Kapoor, Tania, Gazumyan, Anna, Keesler, Rebekah I., Jurado, Andrea, Peace, Avery, Agudelo, Marianna, Watanabe, Jennifer, Usachenko, Jodie, Singapuri, Anil, Immareddy, Ramya, Ardeshir, Amir, Stuart, Jackson B., Bournazos, Stylianos, Ravetch, Jeffrey V., Balderes, Paul J., Lorenz, Ivo C., Esswein, Shannon R., Keeffe, Jennifer R., Bjorkman, Pamela J., Wang, Qiao, Rice, Charles M., MacDonald, Margaret R., Nussenzweig, Michel C., Robbiani, Davide F.

“…Human infection by Zika virus (ZIKV) during pregnancy can lead to vertical transmission and fetal aberrations, including microcephaly. Prophylactic…”
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Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody by Esswein, Shannon R., Gristick, Harry B., Jurado, Andrea, Peace, Avery, Keeffe, Jennifer R., Lee, Yu E., Voll, Alisa V., Saeed, Mohsan, Nussenzweig, Michel C., Rice, Charles M., Robbiani, Davide F., MacDonald, Margaret R., Bjorkman, Pamela J.

“…Recent epidemics demonstrate the global threat of Zika virus (ZIKV), a flavivirus transmitted by mosquitoes. Although infection is usually asymptomatic or…”
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Comparison of patient‐reported outcomes and clinical characteristics among patients with pituitary macroadenomas and giant adenomas by Miller, Jessa E., Chung, Hye Rhyn, Uy, Benjamin R., Kosaraju, Nikitha, Shih, Ryan M., Ko, Myungjun, Esswein, Shannon R., Abiri, Arash, Khosravi, Pooya, Huck, Nolan, Nguyen, Cecilia H., Hsu, Timothy, Kim, Michael G., Hsu, Frank P. K., Kim, Won, Lee, Jivianne K., Suh, Jeffrey D., Bergsneider, Marvin, Kuan, Edward C., Wang, Marilene B.

“…Key points Patients with giant adenomas are more likely to have tumor extension into the paranasal sinuses. Compared to macroadenomas, giant adenomas are not…”
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Structural Basis for Germline Antibody Binding to Zika Virus Envelope Domain III by Esswein, Shannon R., Bjorkman, Pamela J.

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Identification of Segments in Variable Domains of IG Light Chains that Drive Formation of Amyloid Fibrils by Esswein, Shannon R., Brumshtein, Boris, Eisenberg, David S.

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Stabilization of Variable Domain Dimers of an Immunoglobulin Light Chain Inhibits Formation of Amyloid Fibrils by Esswein, Shannon R., Brumshtein, Boris, Eisenberg, David S.

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Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis by Brumshtein, Boris, Esswein, Shannon R., Sawaya, Michael R., Rosenberg, Gregory, Ly, Alan T., Landau, Meytal, Eisenberg, David S.

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