Search Results - "Essink, Monika"

A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase by Patel, Naina, Krishnan, Shekhar, Offman, Marc N, Krol, Marcin, Moss, Catherine X, Leighton, Carly, van Delft, Frederik W, Holland, Mark, Liu, Jizhong, Alexander, Seema, Dempsey, Clare, Ariffin, Hany, Essink, Monika, Eden, Tim O B, Watts, Colin, Bates, Paul A, Saha, Vaskar

“…l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There is wide individual variation in…”
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Intramuscular PEG-Asparaginase At 1000 U/m2 Achieves Adequate Trough Activity Levels in the Majority of Patients Treated on the UKALL 2003 Childhood Acute Lymphoblastic Leukemia (ALL) Protocol by Fong, Caroline YK, Parker, Catriona Anne, Hussain, Adiba, Liu, Jizhong, Essink, Monika, Kuehnel, Hans Juergen, Lancaster, Donna L, Pridham, Genevieve, Payne, Debbie, O'Horo, Charlotte, Krishnan, Shekhar, Hancock, Jeremy, Goulden, Nicholas, Moorman, Anthony V., Richards, Sue, Vora, Ajay J, Saha, Vaskar, Masurekar, Ashish Narayan

“…Abstract 2573 Polyethylene glycol conjugated L-asparaginase (PEG-ASNase) is used in varying doses between 1000–2500 U/m2 in the therapy of ALL and associated…”
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Lymphoblasts Produce a Lysosomal Protease That Rapidly Degrades L-Asparaginase - Implications for Therapy in Childhood Acute Lymphoblastic Leukemia by Patel, Naina, Krishnan, Shekhar, Offman, Marc N., Moss, Cathy X., Ariffin, Hany, vanDelft, Fred W., Yiannikouris, Olga, Leighton, Carly, Alexander, Seema, Holland, Mark, Khater, Doaa, Liu, Ji Zhong, Essink, Monika, Bates, Paul, Watts, Colin, Saha, Vaskar

“…The efficacy of the key anti-leukaemic agent E.coli L-Asparaginase (L-Asp) is limited by variable therapeutic activity and development of…”
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Accidental overdose of mitoxantrone in three patients by Siegert, W, Hiddemann, W, Koppensteiner, R, Büchner, T, Essink, M, Huhn, D, Jung, M, Marosi, L, Martin, T, Minar, E

“…Mitoxantrone is a new effective antineoplastic agent with activity against a wide range of tumors. Compared with the anthracycline drugs doxo- and…”
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