Search Results - "Essex, David W"

The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis by Zhou, Junsong, Wu, Yi, Wang, Lu, Rauova, Lubica, Hayes, Vincent M, Poncz, Mortimer, Essex, David W

“…Protein disulfide isomerase (PDI) has two distinct CGHC redox-active sites; however, the contribution of these sites during different physiologic reactions,…”
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The transmembrane protein disulfide isomerase TMX1 negatively regulates platelet responses by Zhao, Zhenzhen, Wu, Yi, Zhou, Junsong, Chen, Fengwu, Yang, Aizhen, Essex, David W.

“…Secreted platelet protein disulfide isomerases, PDI, ERp57, ERp5, and ERp72, have important roles as positive regulators of platelet function and thrombosis…”
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The disulfide isomerase ERp72 supports arterial thrombosis in mice by Zhou, Junsong, Wu, Yi, Chen, Fengwu, Wang, Lu, Rauova, Lubica, Hayes, Vincent M., Poncz, Mortimer, Li, Hong, Liu, Tong, Liu, Junling, Essex, David W.

“…Several CGHC motif–containing disulfide isomerases support thrombosis. We here report that endoplasmic reticulum protein 72 (ERp72), with 3 CGHC redox-active…”
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Mediastinal Lymphoma Presenting in Cardiogenic Shock with Superior Vena Cava Syndrome in a Primigravida at Full Term: Salvage Resection after Prolonged Extracorporeal Life Support by Carro, Sabrina E., Essex, David W., Alsammak, Mohamed, Bains, Ashish, Toyoda, Yoshiya, Keshavamurthy, Suresh

“…Primary mediastinal large B-cell lymphoma (PMBCL) is a rare type of non-Hodgkin lymphoma that typically has a good response rate to first line chemotherapy…”
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Recent advances in vascular thiol isomerases and redox systems in platelet function and thrombosis by Essex, David W., Wang, Lu

“…There have been substantial advances in vascular protein disulfide isomerases (PDIs) in platelet function and thrombosis in recent years. There are 4 known…”
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Vascular thiol isomerases in thrombosis: The yin and yang by Wu, Yi, Essex, David W.

“…There has recently been considerable progress of the field of extracellular protein disulfide isomerases with vascular thiol isomerases in the forefront. Four…”
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Enzymatically catalyzed disulfide exchange is required for platelet adhesion to collagen via integrin α2β1 by Lahav, Judith, Wijnen, Eveline M., Hess, Oded, Hamaia, Samir W., Griffiths, Delia, Makris, Michael, Knight, C. Graham, Essex, David W., Farndale, Richard W.

“…Integrin α2β1 is the principal adhesive receptor for collagen but platelets also adhere through glycoprotein VI (GPVI). Integrin αIIbβ3 may augment platelet…”
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Multiple protein disulfide isomerases support thrombosis by Essex, David W, Wu, Yi

“…PURPOSE OF REVIEWThe present review provides an overview of recent findings on new members of the protein disulfide isomerase (PDI) family required for…”
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Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin by Wang, Lu, Wu, Yi, Zhou, Junsong, Ahmad, Syed S., Mutus, Bulent, Garbi, Natalio, Hämmerling, Günter, Liu, Junling, Essex, David W.

“…The platelet protein disulfide isomerase called ERp57 mediates platelet aggregation, but its role in thrombus formation is unknown. To determine the specific…”
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A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice by Zhou, Junsong, Wu, Yi, Rauova, Lubica, Koma, Gavin, Wang, Lu, Poncz, Mortimer, Li, Hong, Liu, Tong, Fong, Karen P., Bennett, Joel S., Kunapuli, Satya P., Essex, David W.

“…Although several members of protein disulfide isomerase (PDI) family support thrombosis, other PDI family members with the CXYC motif remain uninvestigated…”
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The b′ domain of protein disulfide isomerase cooperates with the a and a′ domains to functionally interact with platelets by Wang, Lu, Zhou, Junsong, Wang, Lei, Wang, Chih‐chen, Essex, David W.

“…Essentials Protein disulfide isomerase (PDI) interacts with the αIIbβ3 integrin on platelets We generated PDI domain fragments and full‐length PDI containing…”
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Protein disulfide isomerase enhances tissue factor-dependent thrombin generation by Chen, Fengwu, Zhao, Zhenzhen, Zhou, Junsong, Lu, Yi, Essex, David W., Wu, Yi

“…Protein disulfide isomerase (PDI) plays an important role in fibrin generation in vivo, but the underlying mechanism remains largely unknown. In this study,…”
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Redox control of platelet function by Essex, David W

“…There has recently been a dramatic expansion in research in the area of redox biology with systems that utilize thiols to perform redox chemistry being central…”
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Protein disulfide isomerase A1 as a novel redox sensor in VEGFR2 signaling and angiogenesis by Nagarkoti, Sheela, Kim, Young-Mee, Ash, Dipankar, Das, Archita, Vitriol, Eric, Read, Tracy-Ann, Youn, Seock-Won, Sudhahar, Varadarajan, McMenamin, Malgorzata, Hou, Yali, Boatwright, Harriet, Caldwell, Ruth, Essex, David W., Cho, Jaehyung, Fukai, Tohru, Ushio-Fukai, Masuko

“…VEGFR2 signaling in endothelial cells (ECs) is regulated by reactive oxygen species (ROS) derived from NADPH oxidases (NOXs) and mitochondria, which plays an…”
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The disulfide isomerase ERp57 mediates platelet aggregation, hemostasis, and thrombosis by Wu, Yi, Ahmad, Syed S., Zhou, Junsong, Wang, Lu, Cully, Matthew P., Essex, David W.

“…A close homologue to protein disulfide isomerase (PDI) called ERp57 forms disulfide bonds in glycoproteins in the endoplasmic reticulum and is expressed on the…”
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Thioredoxin-related transmembrane protein 1 negatively regulates coagulation and phosphatidylserine exposure by Zhou, Junsong, Rico, Mario C., Rauova, Lubica, Poncz, Mortimer, Essex, David W.

“…Five secreted platelet protein disulfide isomerases (PDIs) and 1 transmembrane PDI regulate platelet function and thrombosis. Thioredoxin-related transmembrane…”
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P2Y12 receptor inhibition and LPS-induced coagulation by Essex, David W, Rao, A Koneti

“…Platelets play a major role in the complex interactions involved in blood coagulation via multiple mechanisms. As reported in this issue, Schoergenhofer et al…”
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The role of thiols and disulfides in platelet function by Essex, David W

“…Disulfide bonds formed in newly synthesized proteins in the endoplasmic reticulum of cells are important for protein structure and stability. Recent research,…”
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Protein disulphide isomerase in platelet function by Manickam, Nagaraj, Sun, Xiuhua, Li, Mengru, Gazitt, Yair, Essex, David W.

“…Summary Platelet protein disulphide isomerase (PDI) has a role in platelet aggregation, probably targeting a thiol‐containing platelet surface protein. The…”
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Redox Control of Platelet Aggregation by Essex, David W, Li, Mengru

“…Sulfhydryl and disulfide metabolism in platelet function has recently reemerged as a focus of platelet research. In this study we tested the effect of redox…”
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