Search Results - "Essenburg, Curt J"

Glesatinib Exhibits Antitumor Activity in Lung Cancer Models and Patients Harboring MET Exon 14 Mutations and Overcomes Mutation-mediated Resistance to Type I MET Inhibitors in Nonclinical Models by Engstrom, Lars D, Aranda, Ruth, Lee, Matthew, Tovar, Elizabeth A, Essenburg, Curt J, Madaj, Zachary, Chiang, Harrah, Briere, David, Hallin, Jill, Lopez-Casas, Pedro P, Baños, Natalia, Menendez, Camino, Hidalgo, Manuel, Tassell, Vanessa, Chao, Richard, Chudova, Darya I, Lanman, Richard B, Olson, Peter, Bazhenova, Lyudmilla, Patel, Sandip Pravin, Graveel, Carrie, Nishino, Mizuki, Shapiro, Geoffrey I, Peled, Nir, Awad, Mark M, Jänne, Pasi A, Christensen, James G

“…exon 14 deletion ( ex14 del) mutations represent a novel class of non-small cell lung cancer (NSCLC) driver mutations. We evaluated glesatinib, a…”
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Genomic Status of MET Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath Tumors by Peacock, Jacqueline D, Pridgeon, Matthew G, Tovar, Elizabeth A, Essenburg, Curt J, Bowman, Megan, Madaj, Zachary, Koeman, Julie, Boguslawski, Elissa A, Grit, Jamie, Dodd, Rebecca D, Khachaturov, Vadim, Cardona, Diana M, Chen, Mark, Kirsch, David G, Maina, Flavio, Dono, Rosanna, Winn, Mary E, Graveel, Carrie R, Steensma, Matthew R

“…Malignant peripheral nerve sheath tumors (MPNST) are highly resistant sarcomas that occur in up to 13% of individuals with neurofibromatosis type I (NF1)…”
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Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling by Grit, Jamie L, Johnson, Benjamin K, Dischinger, Patrick S, J Essenburg, Curt, Adams, Marie, Campbell, Stacy, Pollard, Kai, Pratilas, Christine A, Triche, Jr, Tim J, Graveel, Carrie R, Steensma, Matthew R

“…Benign peripheral nerve sheath tumors are the clinical hallmark of Neurofibromatosis Type 1. They account for substantial morbidity and mortality in NF1…”
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NF1 deficiency drives metabolic reprogramming in ER+ breast cancer by House, Rachel (Rae) J., Tovar, Elizabeth A., Redlon, Luke N., Essenburg, Curt J., Dischinger, Patrick S., Ellis, Abigail E., Beddows, Ian, Sheldon, Ryan D., Lien, Evan C., Graveel, Carrie R., Steensma, Matthew R.

“…NF1 is a tumor suppressor gene and its protein product, neurofibromin, is a negative regulator of the RAS pathway. NF1 is one of the top driver mutations in…”
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Nf1 deficiency modulates the stromal environment in the pretumorigenic rat mammary gland by Arumugam, Menusha, Tovar, Elizabeth A, Essenburg, Curt J, Dischinger, Patrick S, Beddows, Ian, Wolfrum, Emily, Madaj, Zach B, Turner, Lisa, Feenstra, Kristin, Gallik, Kristin L, Cohen, Lorna, Nichols, Madison, Sheridan, Rachel T C, Esquibel, Corinne R, Mouneimne, Ghassan, Graveel, Carrie R, Steensma, Matthew R

“…Neurofibromin, coded by the tumor suppressor gene, is the main negative regulator of the RAS pathway and is frequently mutated in various cancers. Women with…”
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Ex Vivo Patient-Derived Explant Model for Neurofibromatosis Type 1-Related Cutaneous Neurofibromas by Grit, Jamie L, Turner, Lisa, Essenburg, Curt J, Gallik, Kristin L, Dischinger, Patrick S, Shurlow, Nathan D, Pate, Matthew J, Graveel, Carrie R, Steensma, Matthew R

“…Cutaneous neurofibromas (CNFs) are benign tumors that occur in the dermis of individuals with the inherited tumor predisposition disorder, neurofibromatosis…”
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p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs by Grit, Jamie L., McGee, Lauren E., Tovar, Elizabeth A., Essenburg, Curt J., Wolfrum, Emily, Beddows, Ian, Williams, Kaitlin, Sheridan, Rachael T. C., Schipper, Joshua L., Adams, Marie, Arumugam, Menusha, Vander Woude, Thomas, Gurunathan, Sharavana, Field, Jeffrey M., Wulfkuhle, Julia, Petricoin, Emanuel F., Graveel, Carrie R., Steensma, Matthew R.

“…Malignant peripheral nerve sheath tumors (MPNSTs) are chemotherapy resistant sarcomas that are a leading cause of death in neurofibromatosis type 1 (NF1)…”
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Cabozantinib (XL184) Inhibits Growth and Invasion of Preclinical TNBC Models by Sameni, Mansoureh, Tovar, Elizabeth A, Essenburg, Curt J, Chalasani, Anita, Linklater, Erik S, Borgman, Andrew, Cherba, David M, Anbalagan, Arulselvi, Winn, Mary E, Graveel, Carrie R, Sloane, Bonnie F

“…Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that is associated with poor clinical outcome. There is a vital need for effective…”
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Targeting MET and EGFR crosstalk signaling in triple-negative breast cancers by Linklater, Erik S, Tovar, Elizabeth A, Essenburg, Curt J, Turner, Lisa, Madaj, Zachary, Winn, Mary E, Melnik, Marianne K, Korkaya, Hasan, Maroun, Christiane R, Christensen, James G, Steensma, Matthew R, Boerner, Julie L, Graveel, Carrie R

“…There is a vital need for improved therapeutic strategies that are effective in both primary and metastatic triple-negative breast cancer (TNBC). Current…”
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Kinome Profiling of NF1-Related MPNSTs in Response to Kinase Inhibition and Doxorubicin Reveals Therapeutic Vulnerabilities by Grit, Jamie L, Pridgeon, Matt G, Essenburg, Curt J, Wolfrum, Emily, Madaj, Zachary B, Turner, Lisa, Wulfkuhle, Julia, Petricoin, 3rd, Emanuel F, Graveel, Carrie R, Steensma, Matthew R

“…Neurofibromatosis Type 1 (NF1)-related Malignant Peripheral Nerve Sheath Tumors (MPNST) are highly resistant sarcomas that account for significant mortality…”
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NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer by Dischinger, Patrick S., Tovar, Elizabeth A., Essenburg, Curt J., Madaj, Zachary B., Gardner, Eve E., Callaghan, Megan E., Turner, Ashley N., Challa, Anil K., Kempston, Tristan, Eagleson, Bryn, Kesterson, Robert A., Bronson, Roderick T., Bowman, Megan J., Graveel, Carrie R., Steensma, Matthew R.

“…The key negative regulatory gene of the RAS pathway, NF1 , is mutated or deleted in numerous cancer types and is associated with increased cancer risk and drug…”
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Dissecting the Rat Mammary Gland: Isolation, Characterization, and Culture of Purified Mammary Epithelial Cells and Fibroblasts by Tovar, Elizabeth A, Sheridan, Rachael, Essenburg, Curt J, Dischinger, Patrick S, Arumugam, Menusha, Callaghan, Megan E, Graveel, Carrie R, Steensma, Matthew R

“…With the advent of CRISPR-Cas and the ability to easily modify the genome of diverse organisms, rat models are being increasingly developed to interrogate the…”
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In vivo Efficacy Studies in Cell Line and Patient-derived Xenograft Mouse Models by Tovar, Elizabeth A, Essenburg, Curt J, Graveel, And Carrie

“…xenograft models derived from human cancer cells have been a gold standard for evaluating the genetic drivers of cancer and are valuable preclinical models for…”
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Abstract B19: MET and IL6 signaling in triple-negative breast cancer by Tovar, Elizabeth A., Sameni, Mansoureh, Essenburg, Curt J., Chalasani, Anita, Linklater, Erik S., Cherba, David M., Anbalagan, Aruselvi, Winn, Mary E., Sloane, Bonnie F., Graveel, Carrie R.

“…Abstract Triple-negative breast cancer (TNBC) accounts for 15-20% of breast cancers and is associated with advanced stage at diagnosis and poorer outcome…”
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Abstract B14: Targeting the intratumoral heterogeneity of receptor tyrosine kinases in breast cancer by Tovar, Elizabeth A., Linklater, Erik S., Essenburg, Curt J., Madaj, Zach, Cherba, David M., Winn, Mary E., Korkaya, Hasan, Boerner, Julie L., Graveel, Carrie R.

“…Abstract Breast cancers display a remarkable phenotypic diversity that is exploited to promote both tumor progression and therapeutic resistance. Recent…”
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