Search Results - "Esplugues, Juan V."

Succinate receptor mediates intestinal inflammation and fibrosis by Macias-Ceja, Dulce C., Ortiz-Masiá, Dolores, Salvador, Pedro, Gisbert-Ferrándiz, Laura, Hernández, Carlos, Hausmann, Martin, Rogler, Gerhard, Esplugues, Juan V., Hinojosa, Joaquín, Alós, Rafael, Navarro, Francisco, Cosin-Roger, Jesus, Calatayud, Sara, Barrachina, María D.

“…Succinate, an intermediate of the tricarboxylic acid cycle, is accumulated in inflamed areas and its signaling through succinate receptor (SUCNR1) regulates…”
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Stimulation of autophagy prevents intestinal mucosal inflammation and ameliorates murine colitis by Macias‐Ceja, Dulce C, Cosín‐Roger, Jesús, Ortiz‐Masiá, Dolores, Salvador, Pedro, Hernández, Carlos, Esplugues, Juan V, Calatayud, Sara, Barrachina, María D

“…Background and Purpose Defective autophagy contributes to the pathogenesis of inflammatory disorders such as inflammatory bowel disease and there are…”
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Interference with mitochondrial function as part of the antifibrogenic effect of Rilpivirine: A step towards novel targets in hepatic stellate cell activation by Benedicto, Ana M., Lucantoni, Federico, Fuster-Martínez, Isabel, Diaz-Pozo, Pedro, Dorcaratto, Dimitri, Muñoz-Forner, Elena, Victor, Victor M., Esplugues, Juan V., Blas-García, Ana, Apostolova, Nadezda

“…Activated hepatic stellate cells (aHSCs), the main perpetrators of liver fibrosis, are a promising therapeutic target in the treatment of chronic liver…”
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M2 macrophages activate WNT signaling pathway in epithelial cells: relevance in ulcerative colitis by Cosín-Roger, Jesús, Ortiz-Masiá, Dolores, Calatayud, Sara, Hernández, Carlos, Alvarez, Angeles, Hinojosa, Joaquin, Esplugues, Juan V, Barrachina, Maria D

“…Macrophages, which exhibit great plasticity, are important components of the inflamed tissue and constitute an essential element of regenerative responses…”
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Mitochondria sentencing about cellular life and death: a matter of oxidative stress by Apostolova, Nadezda, Blas-Garcia, Ana, Esplugues, Juan V

“…Mitochondria are crucial, multifunctional organelles which actively regulate cellular homeostasis. Their complex and diverse role includes maintenance of the…”
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Mitochondrial toxicity in HAART: an overview of in vitro evidence by Apostolova, Nadezda, Blas-García, Ana, Esplugues, Juan V

“…The combined antiretroviral therapeutic approach currently employed for the treatment of HIV infection, known as Higly Active Antiretroviral Therapy (HAART),…”
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Benefits of rilpivirine for liver stiffness in HIV/HCV-coinfected patients by Busca Arenzana, Carmen, González-García, Juan, Blas-García, Ana, Esplugues, Juan V., Olveira Martín, Antonio, Montes Ramírez, Maria Luisa

“…Rilpivirine (RPV) is an antiretroviral drug characterized by good tolerability and a favorable liver safety profile. Recent research has shown that RPV…”
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Looking beyond the Skin: Pathophysiology of Cardiovascular Comorbidity in Psoriasis and the Protective Role of Biologics by Andújar, Isabel, Esplugues, Juan V, García-Martínez, Patricia

“…Psoriasis is a chronic systemic inflammatory disease associated with a higher incidence of cardiovascular disease, especially in patients with moderate to…”
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Anti-inflammatory and immunomodulating effects of rilpivirine: Relevance for the therapeutics of chronic liver disease by Moragrega, Angela B., Gruevska, Aleksandra, Fuster-Martínez, Isabel, Benedicto, Ana M., Tosca, Joan, Montón, Cristina, Victor, Victor M., Esplugues, Juan V., Blas-García, Ana, Apostolova, Nadezda

“…Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease (CLD) worldwide and inflammation is key to its…”
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Oxidative stress and mitochondrial impairment after treatment with anti-HIV drugs: clinical implications by Blas-Garcia, Ana, Apostolova, Nadezda, Esplugues, Juan V

“…Thirty years after the discovery of HIV infection, there are numerous antiretroviral drugs that control the disease when administered in a potent combination…”
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Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells by Blas‐García, Ana, Apostolova, Nadezda, Ballesteros, Daniel, Monleón, Daniel, Morales, Jose M., Rocha, Milagros, Victor, Victor M., Esplugues, Juan V.

“…Efavirenz (EFV) is a non‐nucleoside reverse transcriptase inhibitor (NNRTI) widely used in human immunodeficiency virus (HIV) infection therapy. It has been…”
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Endoplasmic Reticulum and Mitochondria: Independent Roles and Crosstalk in Fatty Liver Diseases and Hepatic Inflammation by Blas-García, Ana, Apostolova, Nadezda, Valls-Bellés, Victoria, Esplugues, Juan V

“…Proper function of the endoplasmic reticulum (ER) and mitochondria is essential for cellular homeostasis and the regulation of metabolic pathways. Perturbation…”
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Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process by Ortiz-Masià, Dolores, Díez, Irene, Calatayud, Sara, Hernández, Carlos, Cosín-Roger, Jesús, Hinojosa, Joaquín, Esplugues, Juan V, Barrachina, María D

“…Inflammation is part of a complex biological response of vascular tissue to pathogens or damaged cells. First inflammatory cells attempt to remove the…”
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Implication of autophagy in the antifibrogenic effect of Rilpivirine: when more is less by Lucantoni, Federico, Benedicto, Ana M., Gruevska, Aleksandra, Moragrega, Ángela B., Fuster-Martínez, Isabel, Esplugues, Juan V., Blas-García, Ana, Apostolova, Nadezda

“…As the main extracellular matrix-producing cells, activated hepatic stellate cells (HSC) are fundamental mediators of liver fibrosis (LF), and understanding…”
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NNRTI and Liver Damage: Evidence of Their Association and the Mechanisms Involved by Benedicto, Ana M., Fuster-Martínez, Isabel, Tosca, Joan, Esplugues, Juan V., Blas-García, Ana, Apostolova, Nadezda

“…Due to the improved effectiveness and safety of combined antiretroviral therapy, human immunodeficiency virus (HIV) infection has become a manageable, chronic…”
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The Heat Stress Response and Diabetes: More Room for Mitochondrial Implication by Miova, Biljana, Dimitrovska, Maja, Dinevska-Kjovkarovska, Suzana, Esplugues, Juan V, Apostolova, Nadezda

“…Heat preconditioning is a rapid cellular adaptive mechanism shared by many cells/ organs / organisms that results in synthesis and accumulation of heat shock…”
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Ensuring the Consistency of Biosimilars by Perez, Isabel Andujar, Blas-Garcia, Ana, Carmona, Loreto, Esplugues, Juan V

“…Biological products are subject to constant reappraisal by regulatory agencies and pharmaceutical companies once they have entered the market, since every…”
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Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development by Ortiz-Masiá, Dolores, Gisbert-Ferrándiz, Laura, Bauset, Cristina, Coll, Sandra, Mamie, Céline, Scharl, Michael, Esplugues, Juan V, Alós, Rafael, Navarro, Francisco, Cosín-Roger, Jesús, Barrachina, María D, Calatayud, Sara

“…The pathogenesis of Crohn's disease-associated fibrostenosis and fistulas imply the epithelial-to-mesenchymal transition (EMT) process. As succinate and its…”
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Diminished Vitamin D Receptor Protein Levels in Crohn's Disease Fibroblasts: Effects of Vitamin D by Gisbert-Ferrándiz, Laura, Cosín-Roger, Jesús, Hernández, Carlos, Macias-Ceja, Dulce C, Ortiz-Masiá, Dolores, Salvador, Pedro, Esplugues, Juan V, Hinojosa, Joaquín, Navarro, Francisco, Calatayud, Sara, Barrachina, María D

“…Vitamin D (VD) deficiency has been associated to Crohn's disease (CD) pathogenesis, and the exogenous administration of VD improves the course of the disease,…”
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Rilpivirine Activates STAT1 in Non-Parenchymal Cells to Regulate Liver Injury in People Living with HIV and MASLD by Moragrega, Ángela B, Busca, Carmen, Apostolova, Nadezda, Olveira, Antonio, Martín-Carbonero, Luz, Valencia, Eulalia, Moreno, Victoria, Bernardino, José I, Abadía, Marta, González-García, Juan, Esplugues, Juan V, Montes, María L, Blas-García, Ana

“…Liver fibrosis is a key determinant of the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Its increasing prevalence and a…”
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