Search Results - "Espinoza‐Chávez, Rocío Marisol"

Structure‐Metabolism Relationships of Benzimidazole Derivatives with anti‐Trypanosoma cruzi Activity for Chagas Disease by Espinoza‐Chávez, Rocío Marisol, Oliveira Rezende Júnior, Celso, Laureano de Souza, Mariana, Consolin Chelucci, Rafael, Michelan‐Duarte, Simone, Krogh, Renata, Gomes Ferreira, Leonardo Luiz, Valli, Marilia, Sena de Oliveira, Aldo, Andricopulo, Adriano D., Carlos Dias, Luiz

“…This study introduces further insights from the hit‐to‐lead optimization process involving a series of benzimidazole derivatives acting as inhibitors of the…”
Get full text

Targeted Protein Degradation for Infectious Diseases: from Basic Biology to Drug Discovery by Espinoza-Chávez, Rocío Marisol, Salerno, Alessandra, Liuzzi, Anastasia, Ilari, Andrea, Milelli, Andrea, Uliassi, Elisa, Bolognesi, Maria Laura

“…Targeted protein degradation (TPD) is emerging as one of the most innovative strategies to tackle infectious diseases. Particularly, proteolysis-targeting…”
Get full text

Chemoinformatics Studies on a Series of Imidazoles as Cruzain Inhibitors by Medeiros, Alex R, Ferreira, Leonardo L G, de Souza, Mariana L, de Oliveira Rezende Junior, Celso, Espinoza-Chávez, Rocío Marisol, Dias, Luiz Carlos, Andricopulo, Adriano D

“…Natural products based on imidazole scaffolds have inspired the discovery of a wide variety of bioactive compounds. Herein, a series of imidazoles that act as…”
Get full text

Structure-activity relationships of novel N -imidazoylpiperazines with potent anti- Trypanosoma cruzi activity by Espinoza-Chávez, Rocío Marisol, Oliveira Rezende Júnior, Celso de, de Souza, Mariana Laureano, Pauli, Ivani, Valli, Marilia, Gomes Ferreira, Leonardo Luiz, Chelucci, Rafael Consolin, Michelan-Duarte, Simone, Krogh, Renata, Romualdo da Silva, Fernando Bezerra, Cruz, Fábio Cardoso, de Oliveira, Aldo Sena, Andricopulo, Adriano Defini, Dias, Luiz Carlos

“…Chagas disease is caused by the parasite , and the lack of effective and safe treatments makes identifying new classes of compounds with anti- activity of…”
Get more information

Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach by de Souza, Mariana L, de Oliveira Rezende Junior, Celso, Ferreira, Rafaela S, Espinoza Chávez, Rocio Marisol, Ferreira, Leonardo L. G, Slafer, Brian W, Magalhães, Luma G, Krogh, Renata, Oliva, Glaucius, Cruz, Fabio Cardoso, Dias, Luiz Carlos, Andricopulo, Adriano D

“…A virtual screening conducted with nearly 4 000 000 compounds from lead-like and fragment-like subsets enabled the identification of a small-molecule inhibitor…”
Get full text