Search Results - "Espinosa, Joaquin M"

Down Syndrome and COVID-19: A Perfect Storm? by Espinosa, Joaquin M.

“…People with Down syndrome show signs of chronic immune dysregulation, including a higher prevalence of autoimmune disorders, increased rates of hospitalization…”
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Mechanisms of transcriptional regulation by p53 by Sullivan, Kelly D, Galbraith, Matthew D, Andrysik, Zdenek, Espinosa, Joaquin M

“…p53 is a transcription factor that suppresses tumor growth through regulation of dozens of target genes with diverse biological functions. The activity of this…”
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Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response by Andrysik, Zdenek, Bender, Heather, Galbraith, Matthew D., Espinosa, Joaquin M.

“…Cellular adaptation to hypoxia is a hallmark of cancer, but the relative contribution of hypoxia-inducible factors (HIFs) versus other oxygen sensors to…”
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PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response by Andrysik, Zdenek, Sullivan, Kelly D., Kieft, Jeffrey S., Espinosa, Joaquin M.

“…The p53 transcription factor is a master regulator of cellular stress responses inhibited by repressors such as MDM2 and the phosphatase PPM1D. Activation of…”
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Multi-omics investigation reveals functional specialization of transcriptional cyclin dependent kinases in cancer biology by Donovan, Micah G., Galbraith, Matthew D., Espinosa, Joaquin M.

“…Transcriptional addiction is recognized as a valid therapeutic target in cancer, whereby the dependency of cancer cells on oncogenic transcriptional regulators…”
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Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors by Powers, Rani K., Culp-Hill, Rachel, Ludwig, Michael P., Smith, Keith P., Waugh, Katherine A., Minter, Ross, Tuttle, Kathryn D., Lewis, Hannah C., Rachubinski, Angela L., Granrath, Ross E., Carmona-Iragui, María, Wilkerson, Rebecca B., Kahn, Darcy E., Joshi, Molishree, Lleó, Alberto, Blesa, Rafael, Fortea, Juan, D’Alessandro, Angelo, Costello, James C., Sullivan, Kelly D., Espinosa, Joaquin M.

“…Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by ill-defined mechanisms. Here we report a large metabolomics study of…”
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Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia by Liang, Kaiwei, Volk, Andrew G., Haug, Jeffrey S., Marshall, Stacy A., Woodfin, Ashley R., Bartom, Elizabeth T., Gilmore, Joshua M., Florens, Laurence, Washburn, Michael P., Sullivan, Kelly D., Espinosa, Joaquin M., Cannova, Joseph, Zhang, Jiwang, Smith, Edwin R., Crispino, John D., Shilatifard, Ali

“…Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner genes result in aggressive leukemia with dismal outcomes. Despite…”
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Trisomy 21 increases microtubules and disrupts centriolar satellite localization by McCurdy, Bailey L, Jewett, Cayla E, Stemm-Wolf, Alexander J, Duc, Huy Nguyen, Joshi, Molishree, Espinosa, Joaquin M, Prekeris, Rytis, Pearson, Chad G

“…Trisomy 21, the source of Down syndrome, causes a 0.5-fold protein increase of the chromosome 21-resident gene Pericentrin (PCNT) and reduces primary cilia…”
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Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms by Allen, Mary Ann, Andrysik, Zdenek, Dengler, Veronica L, Mellert, Hestia S, Guarnieri, Anna, Freeman, Justin A, Sullivan, Kelly D, Galbraith, Matthew D, Luo, Xin, Kraus, W Lee, Dowell, Robin D, Espinosa, Joaquin M

“…The p53 transcription factor is a potent suppressor of tumor growth. We report here an analysis of its direct transcriptional program using Global Run-On…”
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Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs With Trisomy 21 by Klein, Jenny A, Li, Zhen, Rampam, Sanjeev, Cardini, Jack, Ayoub, Amara, Shaw, Patricia, Rachubinski, Angela L, Espinosa, Joaquin M, Zeldich, Ella, Haydar, Tarik F

“…The intellectual disability found in people with Down syndrome is associated with numerous changes in early brain development, including the proliferation and…”
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Variegated overexpression of chromosome 21 genes reveals molecular and immune subtypes of Down syndrome by Donovan, Micah G., Eduthan, Neetha P., Smith, Keith P., Britton, Eleanor C., Lyford, Hannah R., Araya, Paula, Granrath, Ross E., Waugh, Katherine A., Enriquez Estrada, Belinda, Rachubinski, Angela L., Sullivan, Kelly D., Galbraith, Matthew D., Espinosa, Joaquin M.

“…Individuals with Down syndrome, the genetic condition caused by trisomy 21, exhibit strong inter-individual variability in terms of developmental phenotypes…”
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Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients as a function of therapeutic transfusion and hydroxyurea treatment by D'Alessandro, Angelo, Nouraie, S Mehdi, Zhang, Yingze, Cendali, Francesca, Gamboni, Fabia, Reisz, Julie A, Zhang, Xu, Bartsch, Kyle W, Galbraith, Matthew D, Espinosa, Joaquin M, Gordeuk, Victor R, Gladwin, Mark T

“…Metabolomics studies in sickle cell disease (SCD) have been so far limited to tens of samples, owing to technical and experimental limitations. To overcome…”
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The Human CDK8 Subcomplex Is a Histone Kinase That Requires Med12 for Activity and Can Function Independently of Mediator by Knuesel, Matthew T., Meyer, Krista D., Donner, Aaron J., Espinosa, Joaquin M., Taatjes, Dylan J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas by Abraham, Christopher G., Ludwig, Michael P., Andrysik, Zdenek, Pandey, Ahwan, Joshi, Molishree, Galbraith, Matthew D., Sullivan, Kelly D., Espinosa, Joaquin M.

“…The transcriptional repressor ΔNp63α is a potent oncogene widely overexpressed in squamous cell carcinomas (SCCs) of diverse tissue origins, where it promotes…”
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JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome by Tuttle, Kathryn D., Waugh, Katherine A., Araya, Paula, Minter, Ross, Orlicky, David J., Ludwig, Michael, Andrysik, Zdenek, Burchill, Matthew A., Tamburini, Beth A.J., Sempeck, Colin, Smith, Keith, Granrath, Ross, Tracy, Dayna, Baxter, Jessica, Espinosa, Joaquin M., Sullivan, Kelly D.

“…Individuals with Down syndrome (DS; trisomy 21) display hyperactivation of interferon (IFN) signaling and chronic inflammation, which could potentially be…”
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Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome by Donovan, Micah G., Rachubinski, Angela L., Smith, Keith P., Araya, Paula, Waugh, Katherine A., Enriquez-Estrada, Belinda, Britton, Eleanor C., Lyford, Hannah R., Granrath, Ross E., Schade, Kyndal A., Kinning, Kohl T., Paul Eduthan, Neetha, Sullivan, Kelly D., Galbraith, Matthew D., Espinosa, Joaquin M.

“…Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by delayed neurodevelopment, accelerated aging, and increased risk of…”
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Severely ill and high-risk COVID-19 patients exhibit increased peripheral circulation of CD62L+ and perforin+ T cells by Lesteberg, Kelsey E, Araya, Paula, Waugh, Katherine A, Chauhan, Lakshmi, Espinosa, Joaquin M, Beckham, J David

“…The emergence of SARS-CoV-2, which causes COVID-19, has led to over 400 million reported cases worldwide. COVID-19 disease ranges from asymptomatic infection…”
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FAM193A is a positive regulator of p53 activity by Szwarc, Maria M., Guarnieri, Anna L., Joshi, Molishree, Duc, Huy N., Laird, Madison C., Pandey, Ahwan, Khanal, Santosh, Dohm, Emily, Bui, Aimee K., Sullivan, Kelly D., Galbraith, Matthew D., Andrysik, Zdenek, Espinosa, Joaquin M.

“…Inactivation of the p53 tumor suppressor, either by mutations or through hyperactivation of repressors such as MDM2 and MDM4, is a hallmark of cancer. Although…”
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Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program by Gomes, Nathan P, Bjerke, Glen, Llorente, Briardo, Szostek, Stephanie A, Emerson, Beverly M, Espinosa, Joaquin M

“…Activation of the p53 pathway mediates cellular responses to diverse forms of stress. Here we report that the p53 target gene p21(CIP1) is regulated by stress…”
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The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p by Towers, Christina G., Guarnieri, Anna L., Micalizzi, Doug S., Harrell, J. Chuck, Gillen, Austin E., Kim, Jihye, Wang, Chu-An, Oliphant, Michael U.J., Drasin, David J., Guney, Michelle A., Kabos, Peter, Sartorius, Carol A., Tan, Aik-Choon, Perou, Charles M., Espinosa, Joaquin M., Ford, Heide L.

“…TP53 is mutated in 50% of all cancers, and its function is often compromised in cancers where it is not mutated. Here we demonstrate that the…”
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