Search Results - "Espinosa, Joaquin"

Down Syndrome and COVID-19: A Perfect Storm? by Espinosa, Joaquin M.

“…People with Down syndrome show signs of chronic immune dysregulation, including a higher prevalence of autoimmune disorders, increased rates of hospitalization…”
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Mechanisms of transcriptional regulation by p53 by Sullivan, Kelly D, Galbraith, Matthew D, Andrysik, Zdenek, Espinosa, Joaquin M

“…p53 is a transcription factor that suppresses tumor growth through regulation of dozens of target genes with diverse biological functions. The activity of this…”
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Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response by Andrysik, Zdenek, Bender, Heather, Galbraith, Matthew D., Espinosa, Joaquin M.

“…Cellular adaptation to hypoxia is a hallmark of cancer, but the relative contribution of hypoxia-inducible factors (HIFs) versus other oxygen sensors to…”
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Genes with immune functions modulate key traits associated with Down syndrome in mice by Espinosa, Joaquin M, Sullivan, Kelly D

“…An extra copy of a chromosome region that includes four genes encoding interferon receptors contributes to immune dysregulation, heart malformations,…”
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Role of the Vibrational and Translational Energies in the CN(v)+C2H6(ν1, ν2, ν5 and ν9) Reactions. A Theoretical QCT Study by Espinosa‐Garcia, Joaquin, Rangel, Cipriano, Corchado, Jose C.

“…Quasi‐classical trajectory (QCT) calculations were conducted on the newly developed full‐dimensional potential energy surface, PES‐2023, to analyse two…”
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PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response by Andrysik, Zdenek, Sullivan, Kelly D., Kieft, Jeffrey S., Espinosa, Joaquin M.

“…The p53 transcription factor is a master regulator of cellular stress responses inhibited by repressors such as MDM2 and the phosphatase PPM1D. Activation of…”
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Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover by Fitzwalter, Brent E., Towers, Christina G., Sullivan, Kelly D., Andrysik, Zdenek, Hoh, Maria, Ludwig, Michael, O'Prey, Jim, Ryan, Kevin M., Espinosa, Joaquin M., Morgan, Michael J., Thorburn, Andrew

“…Macroautophagy (autophagy) is intimately linked with cell death and allows cells to evade apoptosis. This has prompted clinical trials to combine autophagy…”
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Multi-omics investigation reveals functional specialization of transcriptional cyclin dependent kinases in cancer biology by Donovan, Micah G., Galbraith, Matthew D., Espinosa, Joaquin M.

“…Transcriptional addiction is recognized as a valid therapeutic target in cancer, whereby the dependency of cancer cells on oncogenic transcriptional regulators…”
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Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation by Sullivan, Kelly D., Evans, Donald, Pandey, Ahwan, Hraha, Thomas H., Smith, Keith P., Markham, Neil, Rachubinski, Angela L., Wolter-Warmerdam, Kristine, Hickey, Francis, Espinosa, Joaquin M., Blumenthal, Thomas

“…Trisomy 21 (T21) causes Down syndrome (DS), but the mechanisms by which T21 produces the different disease spectrum observed in people with DS are unknown. We…”
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Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors by Powers, Rani K., Culp-Hill, Rachel, Ludwig, Michael P., Smith, Keith P., Waugh, Katherine A., Minter, Ross, Tuttle, Kathryn D., Lewis, Hannah C., Rachubinski, Angela L., Granrath, Ross E., Carmona-Iragui, María, Wilkerson, Rebecca B., Kahn, Darcy E., Joshi, Molishree, Lleó, Alberto, Blesa, Rafael, Fortea, Juan, D’Alessandro, Angelo, Costello, James C., Sullivan, Kelly D., Espinosa, Joaquin M.

“…Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by ill-defined mechanisms. Here we report a large metabolomics study of…”
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Transcriptional CDKs in the spotlight by Espinosa, Joaquin M.

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Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia by Liang, Kaiwei, Volk, Andrew G., Haug, Jeffrey S., Marshall, Stacy A., Woodfin, Ashley R., Bartom, Elizabeth T., Gilmore, Joshua M., Florens, Laurence, Washburn, Michael P., Sullivan, Kelly D., Espinosa, Joaquin M., Cannova, Joseph, Zhang, Jiwang, Smith, Edwin R., Crispino, John D., Shilatifard, Ali

“…Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner genes result in aggressive leukemia with dismal outcomes. Despite…”
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Specialized interferon action in COVID-19 by Galbraith, Matthew D, Kinning, Kohl T, Sullivan, Kelly D, Araya, Paula, Smith, Keith P, Granrath, Ross E, Shaw, Jessica R, Baxter, Ryan, Jordan, Kimberly R, Russell, Seth, Dzieciatkowska, Monika, Reisz, Julie A, Gamboni, Fabia, Cendali, Francesca, Ghosh, Tusharkanti, Guo, Kejun, Wilson, Cara C, Santiago, Mario L, Monte, Andrew A, Bennett, Tellen D, Hansen, Kirk C, Hsieh, Elena W Y, D'Alessandro, Angelo, Espinosa, Joaquin M

“…The impacts of interferon (IFN) signaling on COVID-19 pathology are multiple, with both protective and harmful effects being documented. We report here a…”
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Enhanced T cell effector activity by targeting the Mediator kinase module by Freitas, Katherine A, Belk, Julia A, Sotillo, Elena, Quinn, Patrick J, Ramello, Maria C, Malipatlolla, Meena, Daniel, Bence, Sandor, Katalin, Klysz, Dorota, Bjelajac, Jeremy, Xu, Peng, Burdsall, Kylie A, Tieu, Victor, Duong, Vandon T, Donovan, Micah G, Weber, Evan W, Chang, Howard Y, Majzner, Robbie G, Espinosa, Joaquin M, Satpathy, Ansuman T, Mackall, Crystal L

“…T cells are the major arm of the immune system responsible for controlling and regressing cancers. To identify genes limiting T cell function, we conducted…”
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Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions by Steinparzer, Iris, Sedlyarov, Vitaly, Rubin, Jonathan D., Eislmayr, Kevin, Galbraith, Matthew D., Levandowski, Cecilia B., Vcelkova, Terezia, Sneezum, Lucy, Wascher, Florian, Amman, Fabian, Kleinova, Renata, Bender, Heather, Andrysik, Zdenek, Espinosa, Joaquin M., Superti-Furga, Giulio, Dowell, Robin D., Taatjes, Dylan J., Kovarik, Pavel

“…Transcriptional responses to external stimuli remain poorly understood. Using global nuclear run-on followed by sequencing (GRO-seq) and precision nuclear…”
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A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response by Audetat, K. Audrey, Galbraith, Matthew D., Odell, Aaron T., Lee, Thomas, Pandey, Ahwan, Espinosa, Joaquin M., Dowell, Robin D., Taatjes, Dylan J.

“…The human Mediator complex regulates RNA polymerase II transcription genome-wide. A general factor that regulates Mediator function is the four-subunit kinase…”
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JAK inhibition for treatment of psoriatic arthritis in Down syndrome by Pham, Andrew T., Rachubinski, Angela L., Enriquez-Estrada, Belinda, Worek, Kayleigh, Griffith, Melissa, Espinosa, Joaquin M.

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Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs With Trisomy 21 by Klein, Jenny A, Li, Zhen, Rampam, Sanjeev, Cardini, Jack, Ayoub, Amara, Shaw, Patricia, Rachubinski, Angela L, Espinosa, Joaquin M, Zeldich, Ella, Haydar, Tarik F

“…The intellectual disability found in people with Down syndrome is associated with numerous changes in early brain development, including the proliferation and…”
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Trisomy 21 increases microtubules and disrupts centriolar satellite localization by McCurdy, Bailey L, Jewett, Cayla E, Stemm-Wolf, Alexander J, Duc, Huy Nguyen, Joshi, Molishree, Espinosa, Joaquin M, Prekeris, Rytis, Pearson, Chad G

“…Trisomy 21, the source of Down syndrome, causes a 0.5-fold protein increase of the chromosome 21-resident gene Pericentrin (PCNT) and reduces primary cilia…”
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Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms by Allen, Mary Ann, Andrysik, Zdenek, Dengler, Veronica L, Mellert, Hestia S, Guarnieri, Anna, Freeman, Justin A, Sullivan, Kelly D, Galbraith, Matthew D, Luo, Xin, Kraus, W Lee, Dowell, Robin D, Espinosa, Joaquin M

“…The p53 transcription factor is a potent suppressor of tumor growth. We report here an analysis of its direct transcriptional program using Global Run-On…”
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