Recalculating the Route: Repositioning Antimicrobial Peptides for Cancer Treatment

Recalculating the Route: Repositioning Antimicrobial Peptides for Cancer Treatment

Resistance to antimicrobial drugs has been considered a public health problem. Likewise, the increasing resistance of cancer cells to drugs currently used in therapy has also become a problem. Therefore, the research and development of synthetic peptides bring a new perspective on the emergence of n...

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Bibliographic Details
Published in:Chemistry & biodiversity Vol. 21; no. 2; pp. e202301840 - n/a
Main Authors: Almeida Gomes, Isadora, Lima, Ana Beatriz, Silva Brito, Daiane Maria, Almeida Lima, Arlene, Oliveira, Francisco Laio, Espino Zelaya, Elmer Adilson, Magalhães Rebello Alencar, Luciana, Castelo Branco de Souza Collares Maia, Débora, Amaral de Moraes, Maria Elisabete, Pantoja Mesquita, Felipe, Noronha Souza, Pedro Filho, Montenegro, Raquel C.
Format: Journal Article
Language:English
Published: Switzerland Wiley Subscription Services, Inc 01-02-2024
Subjects:
Antimicrobial agents
Antimicrobial peptides
antimicrobials
Bioinformatics
Cancer
cancer cells
Cancer therapies
Cell membranes
Drug resistance
Drugs
Glycoproteins
Membrane proteins
Microenvironments
Microorganisms
Peptides
Protein biosynthesis
Protein synthesis
Proteomics
Public health
R&D
repositioning of peptides
Research & development
resistance to drugs
Synthetic peptides
cancer cells
repositioning of peptides
antimicrobials
resistance to drugs
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Summary:Resistance to antimicrobial drugs has been considered a public health problem. Likewise, the increasing resistance of cancer cells to drugs currently used in therapy has also become a problem. Therefore, the research and development of synthetic peptides bring a new perspective on the emergence of new drugs for treating this resistance since bioinformatics provides a means to optimize these molecules and save time and costs in research. Peptides have several mechanisms of action, such as forming pores on the cell membrane and inhibiting protein synthesis. Some studies report the use of antimicrobial peptides with the potential for action against cancer cells, suggesting a repositioning of antimicrobial peptides to fight back cancer resistance. There is an alteration in the microenvironment, making its net charge negative for the survival and growth of cancer cells. The changes in glycoproteins favor the membrane to have a more negative charge, favoring the interaction between the cells and the peptide, thus making possible the repositioning of these antimicrobial peptides against cancer. Here, we will discuss the mechanism of action, targets and effects of peptides, comparison between microbial and cancer cells, and proteomic changes caused by the interaction of peptides and cells.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202301840