Search Results - "Espelosin, María"

Improvement of cognitive function in wild-type and Alzheimer´s disease mouse models by the immunomodulatory properties of menthol inhalation or by depletion of T regulatory cells by Casares, Noelia, Alfaro, María, Cuadrado-Tejedor, Mar, Lasarte-Cia, Aritz, Navarro, Flor, Vivas, Isabel, Espelosin, María, Cartas-Cejudo, Paz, Fernández-Irigoyen, Joaquín, Santamaría, Enrique, García-Osta, Ana, Lasarte, Juan José

“…A complex network of interactions exists between the olfactory, immune and central nervous systems. In this work we intend to investigate this connection…”
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Amyloid-Driven Tau Accumulation on Mitochondria Potentially Leads to Cognitive Deterioration in Alzheimer's Disease by Cuadrado-Tejedor, Mar, Pérez-González, Marta, Alfaro-Ruiz, Rocío, Badesso, Sara, Sucunza, Diego, Espelosin, María, Ursúa, Susana, Lachen-Montes, Mercedes, Fernández-Irigoyen, Joaquín, Santamaria, Enrique, Luján, Rafael, García-Osta, Ana

“…Despite the well-accepted role of the two main neuropathological markers (β-amyloid and tau) in the progression of Alzheimer's disease, the interaction and…”
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Targeting RNA-Mediated Toxicity in C9orf72 ALS and/or FTD by RNAi-Based Gene Therapy by Martier, Raygene, Liefhebber, Jolanda M., García-Osta, Ana, Miniarikova, Jana, Cuadrado-Tejedor, Mar, Espelosin, Maria, Ursua, Susana, Petry, Harald, van Deventer, Sander J., Evers, Melvin M., Konstantinova, Pavlina

“…A hexanucleotide GGGGCC expansion in intron 1 of chromosome 9 open reading frame 72 (C9orf72) gene is the most frequent cause of amyotrophic lateral sclerosis…”
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Docosahexaenoic Acid Ameliorates Contextual Fear Memory Deficits in the Tg2576 Alzheimer's Disease Mouse Model: Cellular and Molecular Correlates by Badesso, Sara, Cartas-Cejudo, Paz, Espelosin, Maria, Santamaria, Enrique, Cuadrado-Tejedor, Mar, Garcia-Osta, Ana

“…Docosahexaenoic acid (DHA), the most abundant polyunsaturated fatty acid in the brain, is essential for successful aging. In fact, epidemiological studies have…”
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Characterization of brain transduction capability of a BBB-penetrant AAV vector in mice, rats and macaques reveals differences in expression profiles by Bunuales, María, Garduno, Angeles, Chillon, Miguel, Bosch, Assumpció, Gonzalez-Aparicio, Manuela, Espelosin, Maria, Garcia-Gomara, Marta, Rico, Alberto J., Garcia-Osta, Ana, Cuadrado-Tejedor, Mar, Lanciego, Jose L., Hernandez-Alcoceba, Ruben

“…Different screening methods are being developed to generate adeno-associated viral vectors (AAV) with the ability to bypass the blood-brain barrier (BBB) upon…”
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Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease by Rabal, Obdulia, Sánchez-Arias, Juan A., Cuadrado-Tejedor, Mar, de Miguel, Irene, Pérez-González, Marta, García-Barroso, Carolina, Ugarte, Ana, Estella-Hermoso de Mendoza, Ander, Sáez, Elena, Espelosin, Maria, Ursua, Susana, Haizhong, Tan, Wei, Wu, Musheng, Xu, Garcia-Osta, Ana, Oyarzabal, Julen

“…We have identified chemical probes that act as dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors (>1 log unit difference…”
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Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer’s Disease by Rabal, Obdulia, Sánchez-Arias, Juan A, Cuadrado-Tejedor, Mar, de Miguel, Irene, Pérez-González, Marta, García-Barroso, Carolina, Ugarte, Ana, Estella-Hermoso de Mendoza, Ander, Sáez, Elena, Espelosin, Maria, Ursua, Susana, Haizhong, Tan, Wei, Wu, Musheng, Xu, Garcia-Osta, Ana, Oyarzabal, Julen

“…Simultaneous inhibition of phosphodiesterase 5 (PDE5) and histone deacetylases (HDAC) has recently been validated as a potentially novel therapeutic approach…”
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Multitarget Approach for the Treatment of Alzheimer’s Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles by Rabal, Obdulia, Sánchez-Arias, Juan A, Cuadrado-Tejedor, Mar, de Miguel, Irene, Pérez-González, Marta, García-Barroso, Carolina, Ugarte, Ana, Estella-Hermoso de Mendoza, Ander, Sáez, Elena, Espelosin, Maria, Ursua, Susana, Tan, Haizhong, Wu, Wei, Xu, Musheng, Pineda-Lucena, Antonio, Garcia-Osta, Ana, Oyarzabal, Julen

“…Here, we present a series of dual-target phosphodiesterase 9 (PDE9) and histone deacetylase (HDAC) inhibitors devised as pharmacological tool compounds for…”
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Discovery of in Vivo Chemical Probes for Treating Alzheimer’s Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors by Rabal, Obdulia, Sánchez-Arias, Juan A, Cuadrado-Tejedor, Mar, de Miguel, Irene, Pérez-González, Marta, García-Barroso, Carolina, Ugarte, Ana, Estella-Hermoso de Mendoza, Ander, Sáez, Elena, Espelosin, Maria, Ursua, Susana, Haizhong, Tan, Wei, Wu, Musheng, Xu, Garcia-Osta, Ana, Oyarzabal, Julen

“…In order to determine the contributions of histone deacetylase (HDAC) isoforms to the beneficial effects of dual phosphodiesterase 5 (PDE5) and pan-HDAC…”
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Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer’s Disease by Sánchez-Arias, Juan A, Rabal, Obdulia, Cuadrado-Tejedor, Mar, de Miguel, Irene, Pérez-González, Marta, Ugarte, Ana, Sáez, Elena, Espelosin, Maria, Ursua, Susana, Haizhong, Tan, Wei, Wu, Musheng, Xu, Garcia-Osta, Ana, Oyarzabal, Julen

“…A novel systems therapeutics approach, involving simultaneous inhibition of phosphodiesterase 5 (PDE5) and histone deacetylase (HDAC), has been validated as a…”
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PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment by Pérez-González, Marta, Mendioroz, Maite, Badesso, Sara, Sucunza, Diego, Roldan, Miren, Espelosín, Maria, Ursua, Susana, Luján, Rafael, Cuadrado-Tejedor, Mar, Garcia-Osta, Ana

“…•The study of cognitive resilient individuals represents a promising strategy to identify novel therapeutic targets for Alzheimer´s disease (AD).•PLA2G4E is…”
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