Search Results - "Espeillac, Catherine"
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S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy
Published in The Journal of clinical investigation (01-07-2011)“…Rapamycin is an antibiotic inhibiting eukaryotic cell growth and proliferation by acting on target of rapamycin (TOR) kinase. Mammalian TOR (mTOR) is thought…”
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Journal Article -
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S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover
Published in American Journal of Physiology: Cell Physiology (01-08-2007)“…A defect in protein turnover underlies multiple forms of cell atrophy. Since S6 kinase (S6K)-deficient cells are small and display a blunted response to…”
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Journal Article -
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Role of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expression
Published in Biochemical Society transactions (01-08-2013)“…To sustain increased growth, rapidly proliferating cells, such as tumour cells, undergo metabolic adaptations. In recent years, the mechanisms of glycolysis…”
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Journal Article -
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PPARγ contributes to PKM2 and HK2 expression in fatty liver
Published in Nature communications (14-02-2012)“…Rapidly proliferating cells promote glycolysis in aerobic conditions, to increase growth rate. Expression of specific glycolytic enzymes, namely pyruvate…”
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Journal Article -
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The role of the mTOR pathway during liver regeneration and tumorigenesis
Published in Annales d'endocrinologie (01-05-2013)“…Abstract It is established that overnutrition is a risk factor for hepatocellular carcinoma. Il has been proposed that hepatic steatosis leads to a…”
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Journal Article Conference Proceeding -
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PPAR[gamma] contributes to PKM2 and HK2 expression in fatty liver
Published in Nature communications (01-02-2012)“…Rapidly proliferating cells promote glycolysis in aerobic conditions, to increase growth rate. Expression of specific glycolytic enzymes, namely pyruvate…”
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Journal Article