Search Results - "Espada, Jesus"

Current methods to unravel ROS biology by Espada, Jesús

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Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer by Diaz-Lagares, Angel, Crujeiras, Ana B., Lopez-Serra, Paula, Soler, Marta, Setien, Fernando, Goyal, Ashish, Sandoval, Juan, Hashimoto, Yutaka, Martinez-Cardús, Anna, Gomez, Antonio, Heyn, Holger, Moutinho, Catia, Espada, Jesús, Vidal, August, Paúles, Maria, Galán, Maica, Sala, Núria, Akiyama, Yoshimitsu, Martínez-Iniesta, María, Farré, Lourdes, Villanueva, Alberto, Gross, Matthias, Diederichs, Sven, Guil, Sonia, Esteller, Manel

“…Long noncoding RNAs (lncRNAs) are important regulators of cellular homeostasis. However, their contribution to the cancer phenotype still needs to be…”
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Switching on a transient endogenous ROS production in mammalian cells and tissues by Carrasco, Elisa, Blázquez-Castro, Alfonso, Calvo, María I., Juarranz, Ángeles, Espada, Jesús

“…•ROS can play important roles regulating cell proliferation and differentiation.•A transient ROS production can be switched on in cells by a PpIX-dependent…”
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A Photodynamic Tool to Promote a Sustained, ROS-Dependent Growth of Human Hair Follicles in Ex Vivo Culture by Calvo-Sánchez, María I, Fernández-Martos, Sandra, Espada, Jesús

“…Reactive oxygen species (ROS) may severely affect the biochemical viability of most cells. However, ROS may act also as key second messengers regulating…”
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Cellular Intrinsic Factors Involved in the Resistance of Squamous Cell Carcinoma to Photodynamic Therapy by Gilaberte, Yolanda, Milla, Laura, Salazar, Nerea, Vera-Alvarez, Jesús, Kourani, Omar, Damian, Alejandra, Rivarola, Viviana, Roca, Maria José, Espada, Jesús, González, Salvador, Juarranz, Angeles

“…Photodynamic therapy (PDT) is widely used to treat non-melanoma skin cancer. However, some patients affected with squamous cell carcinoma (SCC) do not respond…”
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DNA methylation and the functional organization of the nuclear compartment by Espada, Jesús, Esteller, Manel

“…Symmetrical methylation of cytosine residues at CpG dinucleotides of the DNA molecule is a central epigenetic and heritable hallmark of the genome. This…”
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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer by Caldas, Carlos, Colomer, Dolors, Bonaldi, Tiziana, Lopez, Juan A, Iyer, N Gopalakrishna, Calasanz, Maria J, Pérez-Rosado, Alberto, Cano, Amparo, Ahn, Natalie, Jenuwein, Thomas, Ropero, Santiago, Boix-Chornet, Manuel, Calvo, Enrique, Haydon, Claire, Piris, Miguel Ángel, Esteller, Manel, Fraga, Mario F, Villar-Garea, Ana, Espada, Jesus, Petrie, Kevin, Imhof, Axel, Ballestar, Esteban, Schotta, Gunnar

“…CpG island hypermethylation and global genomic hypomethylation are common epigenetic features of cancer cells. Less attention has been focused on histone…”
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Epigenetic Inactivation of the Premature Aging Werner Syndrome Gene in Human Cancer by Agrelo, Ruben, Cheng, Wen-Hsing, Setien, Fernando, Ropero, Santiago, Espada, Jesus, Fraga, Mario F., Herranz, Michel, Paz, Maria F., Sanchez-Cespedes, Montserrat, Artiga, Maria Jesus, Guerrero, David, Castells, Antoni, von Kobbe, Cayetano, Bohr, Vilhelm A., Esteller, Manel

“…Werner syndrome (WS) is an inherited disorder characterized by premature onset of aging, genomic instability, and increased cancer incidence. The disease is…”
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Protoporphyrin IX-dependent photodynamic production of endogenous ROS stimulates cell proliferation by Blázquez-Castro, Alfonso, Carrasco, Elisa, Calvo, María I., Jaén, Pedro, Stockert, Juan Carlos, Juarranz, Ángeles, Sánz-Rodríguez, Francisco, Espada, Jesús

“…Photodynamic therapy using methyl 5-aminolevulinate (MAL) as a precursor of the photosensitizing agent protoporphyrin IX is widely used in clinical practice…”
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Wnt signalling and cancer stem cells by Espada, Jesús, Calvo, Moisés B., Díaz-Prado, Silvia, Medina, Vanessa

“…Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo…”
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Mouse models in epigenetics: insights in development and disease by Espada, Jesús, Esteller, Manel

“…Epigenetics is devoted to the study of molecular mechanisms that can modify the structure of the chromatin fiber and, in that way, regulate large-scale…”
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Nuclear envelope alterations generate an aging‐like epigenetic pattern in mice deficient in Zmpste24 metalloprotease by Osorio, Fernando G., Varela, Ignacio, Lara, Ester, Puente, Xose S., Espada, Jesús, Santoro, Raffaella, Freije, José M. P., Fraga, Mario F., López‐Otín, Carlos

“…Summary Mutations in the nuclear envelope protein lamin A or in its processing protease ZMPSTE24 cause human accelerated aging syndromes, including…”
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Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells by Espada, Jesús, Ballestar, Esteban, Santoro, Raffaella, Fraga, Mario F, Villar-Garea, Ana, Németh, Attila, Lopez-Serra, Lidia, Ropero, Santiago, Aranda, Agustin, Orozco, Helena, Moreno, Vanessa, Juarranz, Angeles, Stockert, Juan Carlos, Längst, Gernot, Grummt, Ingrid, Bickmore, Wendy, Esteller, Manel

“…The nucleolus is the site of ribosome synthesis in the nucleus, whose integrity is essential. Epigenetic mechanisms are thought to regulate the activity of the…”
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Human DNA Methyltransferase 1 Is Required for Maintenance of the Histone H3 Modification Pattern by Espada, Jesus, Ballestar, Esteban, Fraga, Mario F, Villar-Garea, Ana, Juarranz, Angeles, Stockert, Juan C, Robertson, Keith D, Fuks, François, Esteller, Manel

“…DNA methyltransferase 1 (DNMT1) plays an essential role in murine development and is thought to be the enzyme primarily responsible for maintenance of the…”
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Inactivation of the Lamin A/C Gene by CpG Island Promoter Hypermethylation in Hematologic Malignancies, and Its Association With Poor Survival in Nodal Diffuse Large B-Cell Lymphoma by Agrelo, Ruben, Setien, Fernando, Espada, Jesus, Artiga, Maria Jesus, Rodriguez, Maria, Pérez-Rosado, Alberto, Sanchez-Aguilera, Abel, Fraga, Mario F, Piris, Miguel Angel, Esteller, Manel

“…Lamins support the nuclear envelope and provide anchorage sites for chromatin, but they are also involved in DNA synthesis, transcription, and apoptosis…”
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Hedgehog signalling as a target in cancer stem cells by Medina, Vanessa, Calvo, Moisés B., Díaz-Prado, Silvia, Espada, Jesús

“…Hedgehog (Hh) is one of the most important signalling pathways. Together with the Wnt, TGF-β/BMP and Notch pathways, it is involved in both embryonic…”
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Oncogenic H-Ras and PI3K signaling can inhibit E-cadherin-dependent apoptosis and promote cell survival after photodynamic therapy in mouse keratinocytes by Espada, Jesús, Galaz, Sergio, Sanz-Rodríguez, Francisco, Blázquez-Castro, Alfonso, Stockert, Juan Carlos, Bagazgoitia, Lorea, Jaén, Pedro, González, Salvador, Cano, Amparo, Juarranz, Ángeles

“…Maintenance of E‐cadherin mediated cell–cell contacts is often required for the survival of epithelial cells and tissues. Here we report that oncogenic…”
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The deleterious effects induced by an acute exposure of human skin to common air pollutants are prevented by extracts of Deschampsia antarctica by Fernández-Martos, Sandra, Calvo-Sánchez, María I., Lobo-Aldezabal, Ana, Sánchez-Adrada, Ana Isabel, Moreno, Carmen, Vitale, María, Espada, Jesús

“…The homeostatic and regenerative potential of the skin is critically impaired by an increasing accumulation of air pollutants in human ecosystems. These toxic…”
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Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells by Ropero, Santiago, Setien, Fernando, Espada, Jesus, Fraga, Mario F., Herranz, Michel, Asp, Julia, Benassi, Maria Serena, Franchi, Alessandro, Patiño, Ana, Ward, Laura S., Bovee, Judith, Cigudosa, Juan C., Wim, Wuyts, Esteller, Manel

“…Germline mutations in the Exostoses-1 gene (EXT1) are found in hereditary multiple exostoses syndrome, which is characterized by the formation of…”
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Photoactivation of ROS Production In Situ Transiently Activates Cell Proliferation in Mouse Skin and in the Hair Follicle Stem Cell Niche Promoting Hair Growth and Wound Healing by Carrasco, Elisa, Calvo, María I., Blázquez-Castro, Alfonso, Vecchio, Daniela, Zamarrón, Alicia, de Almeida, Irma Joyce Dias, Stockert, Juan C., Hamblin, Michael R., Juarranz, Ángeles, Espada, Jesús

“…The role of reactive oxygen species (ROS) in the regulation of hair follicle (HF) cycle and skin homeostasis is poorly characterized. ROS have been…”
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