Search Results - "Espíndola, Milena S."

CD18 Regulates Monocyte Hematopoiesis and Promotes Resistance to Experimental Schistosomiasis by Souza, Camila O S, Espíndola, Milena S, Fontanari, Caroline, Prado, Morgana K B, Frantz, Fabiani G, Rodrigues, Vanderlei, Gardinassi, Luiz G, Faccioli, Lúcia H

“…Infection with causes a chronic parasitic disease that progress to severe liver and gastrointestinal damage, and eventually death. During its development into…”
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Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection by Espíndola, Milena S., Soares, Luana S., Galvão-Lima, Leonardo J., Zambuzi, Fabiana A., Cacemiro, Maira C., Brauer, Verônica S., Marzocchi-Machado, Cleni M., de Souza Gomes, Matheus, Amaral, Laurence R., Martins-Filho, Olindo A., Bollela, Valdes R., Frantz, Fabiani G.

“…Monocytes are key cells in the immune dysregulation observed during human immunodeficiency virus (HIV) infection. The events that take place specifically in…”
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Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients by Espíndola, Milena S, Lima, Leonardo J G, Soares, Luana S, Cacemiro, Maira C, Zambuzi, Fabiana A, de Souza Gomes, Matheus, Amaral, Laurence R, Bollela, Valdes R, Martins-Filho, Olindo A, Frantz, Fabiani G

“…Successful highly active antiretroviral therapy (HAART) has changed the outcome of AIDS patients worldwide because the complete suppression of viremia improves…”
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Targeting of TAM Receptors Ameliorates Fibrotic Mechanisms in Idiopathic Pulmonary Fibrosis by Espindola, Milena S, Habiel, David M, Narayanan, Rohan, Jones, Isabelle, Coelho, Ana L, Murray, Lynne A, Jiang, Dianhua, Noble, Paul W, Hogaboam, Cory M

“…Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant lung remodeling, which progressively abolishes lung function in an RTK (receptor tyrosine…”
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HIV infection: focus on the innate immune cells by Espíndola, Milena S., Soares, Luana S., Galvão-Lima, Leonardo J., Zambuzi, Fabiana A., Cacemiro, Maira C., Brauer, Verônica S., Frantz, Fabiani G.

“…Innate immune cells play a critical role during the onset of HIV infection and remain active until the final events that characterize AIDS. The viral impact on…”
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Moojenactivase, a novel pro-coagulant PIIId metalloprotease isolated from Bothrops moojeni snake venom, activates coagulation factors II and X and induces tissue factor up-regulation in leukocytes by Sartim, Marco A., Costa, Tassia R., Laure, Helen J., Espíndola, Milena S., Frantz, Fabiani G., Sorgi, Carlos A., Cintra, Adélia C. O., Arantes, Eliane C., Faccioli, Lucia H., Rosa, José C., Sampaio, Suely V.

“…Coagulopathies following snakebite are triggered by pro-coagulant venom toxins, in which metalloproteases play a major role in envenomation-induced coagulation…”
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Identification of promising plasma immune biomarkers to differentiate active pulmonary tuberculosis by Zambuzi, Fabiana A., Cardoso-Silva, Priscilla M., Espindola, Milena S., Soares, Luana S., Galvão-Lima, Leonardo J., Brauer, Verônica S., Gomes, Matheus S., Amaral, Laurence R., Schaller, Matthew, Bollela, Valdes R., Frantz, Fabiani G.

“…[Display omitted] •Active tuberculosis patients have increased plasma levels of IL-6, IP-10, TNF-α, sCD163 and sCD14.•Simultaneous detection of plasma sCD14…”
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DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis by Habiel, David M, Hohmann, Miriam S, Espindola, Milena S, Coelho, Ana Lucia, Jones, Isabelle, Jones, Heather, Carnibella, Richard, Pinar, Isaac, Werdiger, Freda, Hogaboam, Cory M

“…Recent studies have highlighted the contribution of senescent mesenchymal and epithelial cells in Idiopathic Pulmonary Fibrosis (IPF), but little is known…”
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Classical and alternative macrophages have impaired function during acute and chronic HIV-1 infection by Galvão-Lima, Leonardo J., Espíndola, Milena S., Soares, Luana S., Zambuzi, Fabiana A., Cacemiro, Maira, Fontanari, Caroline, Bollela, Valdes R., Frantz, Fabiani G.

“…Three decades after HIV recognition and its association with AIDS development, many advances have emerged – especially related to prevention and treatment…”
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Mycobacterium tuberculosis expressing phospholipase C subverts PGE2 synthesis and induces necrosis in alveolar macrophages by Assis, Patricia A, Espíndola, Milena S, Paula-Silva, Francisco W G, Rios, Wendy M, Pereira, Priscilla A T, Leão, Sylvia C, Silva, Célio L, Faccioli, Lúcia H

“…Phospholipases C (PLCs) are virulence factors found in several bacteria. In Mycobacterium tuberculosis (Mtb) they exhibit cytotoxic effects on macrophages, but…”
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CCR10+ epithelial cells from idiopathic pulmonary fibrosis lungs drive remodeling by Habiel, David M, Espindola, Milena S, Jones, Isabelle C, Coelho, Ana Lucia, Stripp, Barry, Hogaboam, Cory M

“…Idiopathic pulmonary fibrosis (IPF) is a devastating fibrotic lung disease of unknown etiology and limited therapeutic options. In this report, we characterize…”
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Central lung gene expression associates with myofibroblast features in idiopathic pulmonary fibrosis by Huang, Yong, Guzy, Rob, Ma, Shwu-Fan, Bonham, Catherine A, Jou, Jonathan, Schulte, Jefree J, Kim, John S, Barros, Andrew J, Espindola, Milena S, Husain, Aliya N, Hogaboam, Cory M, Sperling, Anne I, Noth, Imre

“…RationaleContribution of central lung tissues to pathogenesis of idiopathic pulmonary fibrosis (IPF) remains unknown.ObjectiveTo ascertain the relationship…”
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Antibody-mediated depletion of CCR10+EphA3+ cells ameliorates fibrosis in IPF by Hohmann, Miriam S, Habiel, David M, Espindola, Milena S, Huang, Guanling, Jones, Isabelle, Narayanan, Rohan, Coelho, Ana Lucia, Oldham, Justin M, Noth, Imre, Ma, Shwu-Fan, Kurkciyan, Adrianne, McQualter, Jonathan L, Carraro, Gianni, Stripp, Barry, Chen, Peter, Jiang, Dianhua, Noble, Paul W, Parks, William, Woronicz, John, Yarranton, Geoffrey, Murray, Lynne A, Hogaboam, Cory M

“…Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant repair that diminishes lung function via mechanisms that remain poorly understood. CC…”
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Microbes Are Associated with Host Innate Immune Response in Idiopathic Pulmonary Fibrosis by Huang, Yong, Ma, Shwu-Fan, Espindola, Milena S, Vij, Rekha, Oldham, Justin M, Huffnagle, Gary B, Erb-Downward, John R, Flaherty, Kevin R, Moore, Beth B, White, Eric S, Zhou, Tong, Li, Jianrong, Lussier, Yves A, Han, MeiLan K, Kaminski, Naftali, Garcia, Joe G N, Hogaboam, Cory M, Martinez, Fernando J, Noth, Imre

“…Differences in the lung microbial community influence idiopathic pulmonary fibrosis (IPF) progression. Whether the lung microbiome influences IPF host defense…”
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Maladaptive TGF-β Signals to the Alveolar Epithelium Drive Fibrosis after COVID-19 Infection by Yao, Changfu, Parimon, Tanyalak, Espindola, Milena S, Hohmann, Miriam S, Konda, Bindu, Hogaboam, Cory M, Stripp, Barry R, Chen, Peter

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Differential Responses to Targeting Matrix Metalloproteinase 9 in Idiopathic Pulmonary Fibrosis by Espindola, Milena S, Habiel, David M, Coelho, Ana Lucia, Stripp, Barry, Parks, William C, Oldham, Justin, Martinez, Fernando J, Noth, Imre, Lopez, David, Mikels-Vigdal, Amanda, Smith, Victoria, Hogaboam, Cory M

“…Aberrant lung remodeling in idiopathic pulmonary fibrosis (IPF) is characterized by elevated MMP9 (matrix metalloproteinase 9) expression, but the precise role…”
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Immune mechanisms in fibrotic interstitial lung disease by Kamiya, Mari, Carter, Hannah, Espindola, Milena S, Doyle, Tracy J, Lee, Joyce S, Merriam, Louis T, Zhang, Fan, Kawano-Dourado, Leticia, Sparks, Jeffrey A, Hogaboam, Cory M, Moore, Bethany B, Oldham, William M, Kim, Edy Y

“…Fibrotic interstitial lung diseases (fILDs) have poor survival rates and lack effective therapies. Despite evidence for immune mechanisms in lung fibrosis,…”
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Modeling Idiopathic Pulmonary Fibrosis in Humanized Severe Combined Immunodeficient Mice by Habiel, David M., Espindola, Milena S., Coelho, Ana L., Hogaboam, Cory M.

“…Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease of unknown etiopathogenesis with limited therapeutic options. IPF is characterized by an…”
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Reply to D'Alessandro-Gabazza et al.: Risks of Treating Idiopathic Pulmonary Fibrosis with a TAM Receptor Kinase Inhibitor by Espindola, Milena S, Habiel, David M, Hogaboam, Cory M

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Targeting MAP3K19 prevents human lung myofibroblast activation both in vitro and in a humanized SCID model of idiopathic pulmonary fibrosis by Jones, Isabelle C., Espindola, Milena S., Narayanan, Rohan, Coelho, Ana L., Habiel, David M., Boehme, Stefen A., Ly, Tai Wei, Bacon, Kevin B., Hogaboam, Cory M.

“…Idiopathic Pulmonary Fibrosis (IPF) is a disease with a devastating prognosis characterized by unrelenting lung scarring. Aberrant activation of lung…”
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