Search Results - "Esmon, Naomi L"

Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury by Xu, Jun, Zhang, Xiaomei, Monestier, Marc, Esmon, Naomi L, Esmon, Charles T

“…We previously reported that extracellular histones are major mediators of death in sepsis. Infusion of extracellular histones leads to increased cytokine…”
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Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4 by Semeraro, Fabrizio, Ammollo, Concetta T., Morrissey, James H., Dale, George L., Friese, Paul, Esmon, Naomi L., Esmon, Charles T.

“…The release of histones from dying cells is associated with microvascular thrombosis and, because histones activate platelets, this could represent a possible…”
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Thrombomodulin Mutations in Atypical Hemolytic–Uremic Syndrome by Delvaeye, Mieke, Noris, Marina, De Vriese, Astrid, Esmon, Charles T, Esmon, Naomi L, Ferrell, Gary, Del-Favero, Jurgen, Plaisance, Stephane, Claes, Bart, Lambrechts, Diether, Zoja, Carla, Remuzzi, Giuseppe, Conway, Edward M

“…Atypical hemolytic–uremic syndrome, a complex of microangiopathic hemolytic anemia, thrombocytopenia, and renal failure, is not associated with shigella toxin…”
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The link between vascular features and thrombosis by Esmon, Charles T, Esmon, Naomi L

“…The mechanisms of vascular control of thrombotic events remain unclear. The vasculature possesses essential anticoagulant factors that regulate coagulation…”
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PAR1 Cleavage and Signaling in Response to Activated Protein C and Thrombin by Ludeman, Matthew J., Kataoka, Hiroshi, Srinivasan, Yoga, Esmon, Naomi L., Esmon, Charles T., Coughlin, Shaun R.

“…Activated protein C (APC), a natural anticoagulant protease, can trigger cellular responses via protease-activated receptor-1 (PAR1), a G protein-coupled…”
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The Crystal Structure of the Endothelial Protein C Receptor and a Bound Phospholipid by Oganesyan, Vaheh, Oganesyan, Natalia, Terzyan, Simon, Qu, Dongfeng, Dauter, Zbigniew, Esmon, Naomi L., Esmon, Charles T.

“…The endothelial cell protein C receptor (EPCR) shares ∼20% sequence identity with the major histocompatibility complex class 1/CD1 family of molecules,…”
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Extracellular histones are major mediators of death in sepsis by Esmon, Charles T, Xu, Jun, Zhang, Xiaomei, Pelayo, Rosana, Monestier, Marc, Ammollo, Concetta T, Semeraro, Fabrizio, Taylor, Fletcher B, Esmon, Naomi L, Lupu, Florea

“…Extracellular histones released in response to inflammatory challenge contribute to organ failure and death during sepsis. Histone-specific antibodies and…”
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Disruption of the Endothelial Cell Protein C Receptor Gene in Mice Causes Placental Thrombosis and Early Embryonic Lethality by Gu, Jian-Ming, Crawley, James T B, Ferrell, Gary, Zhang, Fangjiu, Li, Weihong, Esmon, Naomi L, Esmon, Charles T

“…The endothelial cell protein C receptor (EPCR) is a type 1 transmembrane protein found primarily on endothelium that binds both protein C and activated protein…”
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Safety and efficacy of an anti–human APC antibody for prophylaxis of congenital factor deficiencies in preclinical models by Jiang, Miao, Yang, Fei, Jiang, Yizhi, Cheng, Lu, Han, Jingjing, Yi, Jiawei, Zuo, Bin, Huang, Lulu, Ma, Zhenni, Li, Tianyi, Cao, Lijuan J., Xia, Zhisong, Bai, Xia, Jia, Chenjun, Yang, Teddy Tat Chi, Esmon, Naomi L., Ruan, Changgeng, Xia, Lijun, Esmon, Charles T., Han, Yue, Wu, Depei, Xu, Jun

“…•We engineered a high-affinity antibody, SR604, which selectively blocks the anticoagulant activity of human APC.•SR604 exhibited prophylactic and therapeutic…”
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Inhibition of endogenous activated protein C attenuates experimental autoimmune encephalomyelitis by inducing myeloid-derived suppressor cells by Alabanza, Leah M, Esmon, Naomi L, Esmon, Charles T, Bynoe, Margaret S

“…Activated protein C (PC) is an anticoagulant involved in the interactions between the coagulation and immune systems. Activated PC has broad anti-inflammatory…”
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Blocking human protein C anticoagulant activity improves clotting defects of hemophilia mice expressing human protein C by Jiang, Miao, Yang, Fei, Jiang, Yizhi, Cheng, Lu, Han, Jingjing, Yi, Jiawei, Zhang, Guige, Ma, Zhenni, Cao, Lijuan, Zuo, Bin, Zhou, Lixia, Huang, Lulu, Niu, Siying, Xia, Zhisong, Zhou, Xuefeng, Bai, Xia, Esmon, Naomi L., Ruan, Changgeng, Xia, Lijun, Han, Yue, Esmon, Charles T., Wu, Depei, Xu, Jun

“…Hemophilia A and B are hereditary coagulation defects resulting in unstable blood clotting and recurrent bleeding. Current factor replacement therapies have…”
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Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice by Shaw, Maureen A., Kombrinck, Keith W., McElhinney, Kathryn E., Sweet, David R., Flick, Matthew J., Palumbo, Joseph S., Cheng, Mei, Esmon, Naomi L., Esmon, Charles T., Brill, Alexander, Wagner, Denisa D., Degen, Jay L., Mullins, Eric S.

“…Thrombin-mediated proteolysis is central to hemostatic function but also plays a prominent role in multiple disease processes. The proteolytic conversion of…”
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The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A by Flick, Matthew J., Chauhan, Anil K., Frederick, Malinda, Talmage, Kathryn E., Kombrinck, Keith W., Miller, Whitney, Mullins, Eric S., Palumbo, Joseph S., Zheng, Xunzhen, Esmon, Naomi L., Esmon, Charles T., Thornton, Sherry, Becker, Ann, Pelc, Leslie A., Di Cera, Enrico, Wagner, Denisa D., Degen, Jay L.

“…Thrombin is a positive mediator of thrombus formation through the proteolytic activation of protease-activated receptors (PARs), fibrinogen, factor XI (fXI),…”
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Extraembryonic expression of EPCR is essential for embryonic viability by Li, Weihong, Zheng, Xunzhen, Gu, Jian-Ming, Ferrell, Gary L., Brady, Mingming, Esmon, Naomi L., Esmon, Charles T.

“…The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-thrombomodulin complex. Deletion of the EPCR gene (Procr) in mice…”
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Inhibition of APC anticoagulant activity on oxidized phospholipid by anti–β2-glycoprotein I monoclonal antibodies by Safa, Omid, Esmon, Charles T., Esmon, Naomi L.

“…Activated protein C (APC) anticoagulant activity and the ability to be inhibited by auto-antibodies associated with thrombosis are strongly augmented by the…”
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Metalloproteolytic Release of Endothelial Cell Protein C Receptor by Xu, Jun, Qu, Dongfeng, Esmon, Naomi L., Esmon, Charles T.

“…Previous studies observed that there is about 100 ng/ml soluble endothelial cell protein C receptor (EPCR) in human plasma and that the levels increase in…”
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Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice by Zheng, Xunzhen, Li, Weihong, Gu, Jian-Ming, Qu, Dongfeng, Ferrell, Gary L., Esmon, Naomi L., Esmon, Charles T.

“…Recent studies have shown that endothelial protein C receptor (EPCR) polymorphisms and soluble EPCR levels are associated with thrombotic diseases. It is…”
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Reconstitution of the Human Endothelial Cell Protein C Receptor with Thrombomodulin in Phosphatidylcholine Vesicles Enhances Protein C Activation by Xu, J, Esmon, N L, Esmon, C T

“…Blocking protein C binding to the endothelial cell protein C receptor (EPCR) on the endothelium is known to reduce protein C activation rates. Now we isolate…”
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Endothelial protein C receptor by Esmon, C T, Xu, J, Gu, J M, Qu, D, Laszik, Z, Ferrell, G, Stearns-Kurosawa, D J, Kurosawa, S, Taylor, Jr, F B, Esmon, N L

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The Effect of Membrane Composition on the Hemostatic Balance by Smirnov, Michael D, Ford, David A, Esmon, Charles T, Esmon, Naomi L

“…The phospholipid composition requirements for optimal prothrombin activation and factor Va inactivation by activated protein C (APC) anticoagulant were…”
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