Search Results - "Esler, W P"

A Portrait of Alzheimer Secretases: New Features and Familiar Faces by Esler, William P., Wolfe, Michael S.

“…The amyloid β-peptide (Aβ) is a principal component of the cerebral plaques found in the brains of patients with Alzeheimer's disease (AD). This insoluble 40-…”
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Point Substitution in the Central Hydrophobic Cluster of a Human β-Amyloid Congener Disrupts Peptide Folding and Abolishes Plaque Competence by Esler, William P, Stimson, Evelyn R, Ghilardi, Joseph R, Lu, Yi-An, Felix, Arthur M, Vinters, Harry V, Mantyh, Patrick W, Lee, Jonathan P, Maggio, John E

“…Alzheimer's disease (AD) is pathologically characterized by the presence of numerous insoluble amyloid plaques in the brain composed primarily of a 40−43 amino…”
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Zinc-induced aggregation of human and rat beta-amyloid peptides in vitro by Esler, W P, Stimson, E R, Jennings, J M, Ghilardi, J R, Mantyh, P W, Maggio, J E

“…The major pathological feature of Alzheimer's disease is the presence of a high density of amyloid plaques in the brain tissue of patients. The plaques are…”
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Aβ deposition inhibitor screen using synthetic amyloid by ESLER, W. P, STIMSON, E. R, GHILARDI, J. R, FELIX, A. M, LU, Y.-A, VINTERS, H. V, MANTYH, P. W, MAGGIO, J. E

“…The formation, growth, and maturation of brain amyloid "senile" plaques are essential pathological processes in Alzheimer's disease (AD) and key targets for…”
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Activity-Dependent Isolation of the Presenilin- γ-Secretase Complex Reveals Nicastrin and a γ Substrate by Esler, William P., Kimberly, W. Taylor, Ostaszewski, Beth L., Ye, Wenjuan, Diehl, Thekla S., Selkoe, Dennis J., Wolfe, Michael S.

“…Presenilin heterodimers apparently contain the active site of γ-secretase, a polytopic aspartyl protease involved in the transmembrane processing of both the…”
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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1 by Esler, W P, Kimberly, W T, Ostaszewski, B L, Diehl, T S, Moore, C L, Tsai, J Y, Rahmati, T, Xia, W, Selkoe, D J, Wolfe, M S

“…The beta-amyloid precursor protein (beta-APP), which is involved in the pathogenesis of Alzheimer's disease, and the Notch receptor, which is responsible for…”
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Alzheimer's Disease Amyloid Propagation by a Template-Dependent Dock-Lock Mechanism by Esler, William P, Stimson, Evelyn R, Jennings, Joan M, Vinters, Harry V, Ghilardi, Joseph R, Lee, Jonathan P, Mantyh, Patrick W, Maggio, John E

“…Amyloid plaques composed of the peptide Aβ are an integral part of Alzheimer's disease (AD) pathogenesis. We have modeled the process of amyloid plaque growth…”
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Notch and the Amyloid Precursor Protein Are Cleaved by Similar γ-Secretase(s) by Kimberly, W. Taylor, Esler, William P, Ye, Wenjuan, Ostaszewski, Beth L, Gao, Jun, Diehl, Thekla, Selkoe, Dennis J, Wolfe, Michael S

“…γ-Secretase is an intramembrane-cleaving protease whose substrates include Notch and the amyloid precursor protein (APP). On the basis of initial genetic and…”
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Fibrillar beta -Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNS In Vivo by Weldon, Derik T, Rogers, Scott D, Ghilardi, Joseph R, Finke, Matthew P, Cleary, James P, O'Hare, Eugene, Esler, William P, Maggio, John E, Mantyh, Patrick W

“…To determine the stability of beta-amyloid peptide (Abeta) and the glial and neuronal changes induced by Abeta in the CNS in vivo, we made single injections of…”
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Deposition of Monomeric, Not Oligomeric, Aβ Mediates Growth of Alzheimer's Disease Amyloid Plaques in Human Brain Preparations by Tseng, Bertrand P, Esler, William P, Clish, Clary B, Stimson, Evelyn R, Ghilardi, Joseph R, Vinters, Harry V, Mantyh, Patrick W, Lee, Jonathan P, Maggio, John E

“…Senile plaques composed of the peptide Aβ contribute to the pathogenesis of Alzheimer's disease (AD), and mechanisms underlying their formation and growth may…”
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In Vitro Growth of Alzheimer's Disease β-Amyloid Plaques Displays First-Order Kinetics by Esler, William P, Stimson, Evelyn R, Ghilardi, Joseph R, Vinters, Harry V, Lee, Jonathan P, Mantyh, Patrick W, Maggio, John E

“…A salient pathological feature of Alzheimer's disease (AD) is the presence of amyloid plaques in the brains of affected patients. The plaques are predominantly…”
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Activation Barriers to Structural Transition Determine Deposition Rates of Alzheimer's Disease Aβ Amyloid by Esler, William P., Felix, Arthur M., Stimson, Evelyn R., Lachenmann, Marcel J., Ghilardi, Joseph R., Lu, Yi-An, Vinters, Harry V., Mantyh, Patrick W., Lee, Jonathan P., Maggio, John E.

“…Brainamyloid composed of the ≈40-amino-acid human β-amyloid peptide Aβ is integral to Alzheimer's disease pathology. To probe the importance of a…”
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Continuing strategies for inhibiting Alzheimer's gamma-secretase by Wolfe, Michael S, Esler, William P, Das, Chittaranjan

“…Gamma-secretase processing of the amyloid-beta precursor protein (APP) releases the amyloid-beta peptide, which is widely held to be involved in the…”
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Deposition of soluble amyloid-beta onto amyloid templates: with application for the identification of amyloid fibril extension inhibitors by Esler, W P, Stimson, E R, Mantyh, P W, Maggio, J E

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γ‐Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila by Micchelli, Craig A., Esler, William P., Kimberly, W. Taylor, Jack, Christine, Berezovska, Oksana, Kornilova, Anna, Hyman, Bradley T., Perrimon, Norbert, Wolfe, Michael S.

“…ABSTRACT Signaling from the Notch (N) receptor is essential for proper cell‐fate determinations and tissue patterning in all metazoans. N signaling requires a…”
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Stereochemical specificity of Alzheimer's disease β-peptide assembly by Esler, William P., Stimson, Evelyn R., Fishman, Jordan B., Ghilardi, Joseph R., Vinters, Harry V., Mantyh, Patrick W., Maggio, John E.

“…The formation and growth of insoluble amyloid deposits composed primarily of the human β‐amyloid peptide (Aβ) in brain is an essentially invariant feature of…”
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Deposition of monomeric, not oligomeric, Abeta mediates growth of Alzheimer's disease amyloid plaques in human brain preparations by Tseng, B P, Esler, W P, Clish, C B, Stimson, E R, Ghilardi, J R, Vinters, H V, Mantyh, P W, Lee, J P, Maggio, J E

“…Senile plaques composed of the peptide Abeta contribute to the pathogenesis of Alzheimer's disease (AD), and mechanisms underlying their formation and growth…”
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Zinc and Alzheimer's Disease by Fitzgerald, D. James, Maggio, John E., Esler, William P., Stimson, Evelyn R., Jennings, Joan M., Ghilardi, Joseph R., Mantyh, Patrick W., Bush, Ashley I., Moir, Robert D., Rosenkranz, Kari M., Tanzi, Rudolph E.

“…The accuracy of a claim that zinc ions enhances aggregation of beta-amyloid protein, associated with Alzheimer's disease, is disputed. The original paper is…”
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Amyloid-lowering isocoumarins are not direct inhibitors of γ-secretase by Esler, William P, Das, Chittaranjan, Campbell, William A, Kimberly, W. Taylor, Kornilova, Anna Y, Diehl, Thekla S, Ye, Wenjuan, Ostaszewski, Beth L, Xia, Weiming, Selkoe, Dennis J, Wolfe, Michael S

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Zinc and Alzheimer's disease by Maggio, J E, Esler, W P, Stimson, E R, Jennings, J M, Ghilardi, J R, Mantyh, P W

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