Search Results - "Eskandari, Ghazaleh"

Microglial APOE4: more is less and less is more by Eskandari-Sedighi, Ghazaleh, Blurton-Jones, Mathew

“…Apolipoprotein E (APOE) is the single greatest genetic risk factor for late onset Alzheimer's disease (AD). Yet, the cell-specific effects of APOE on microglia…”
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Correction: Dual inhibition of IGF-IR and ALK as an effective strategy to eradicate NPM-ALK + T-cell lymphoma by George, Bhawana, George, Suraj Konnath, Shi, Wenyu, Haque, Abedul, Shi, Ping, Eskandari, Ghazaleh, Axelson, Magnus, Larsson, Olle, Kaseb, Ahmed O, Amin, Hesham M

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Correction to: Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT‑P301L mutation by Daude, Nathalie, Kim, Chae, Kang, Sang‑Gyun, Eskandari‑Sedighi, Ghazaleh, Haldiman, Tracy, Yang, Jing, Fleck, Shelaine C., Gomez‑Cardona, Erik, Han, Zhuang Zhuang, Borrego‑Ecija, Sergi, Wohlgemuth, Serene, Julien, Olivier, Wille, Holger, Molina‑Porcel, Laura, Gelpi, Ellen, Safar, Jiri G., Westaway, David

“…In the original publication, Table 1 column heads are incorrectly formatted and aligned. The corrected Table 1 is given here…”
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Dual inhibition of IGF-IR and ALK as an effective strategy to eradicate NPM-ALK + T-cell lymphoma by George, Bhawana, George, Suraj Konnath, Shi, Wenyu, Haque, Abedul, Shi, Ping, Eskandari, Ghazaleh, Axelson, Magnus, Larsson, Olle, Kaseb, Ahmed O, Amin, Hesham M

“…Nucleophosmin-anaplastic lymphoma kinase-expressing (NPM-ALK ) T cell lymphoma is an aggressive neoplasm. NPM-ALK, an oncogenic tyrosine kinase, plays a…”
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The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia by Bhattacherjee, Abhishek, Jung, Jaesoo, Zia, Sameera, Ho, Madelene, Eskandari-Sedighi, Ghazaleh, St. Laurent, Chris D., McCord, Kelli A., Bains, Arjun, Sidhu, Gaurav, Sarkar, Susmita, Plemel, Jason R., Macauley, Matthew S.

“…Abstract Background CD33 is genetically linked to Alzheimer’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of…”
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Cellular Biology of Tau Diversity and Pathogenic Conformers by Kang, Sang-Gyun, Eskandari-Sedighi, Ghazaleh, Hromadkova, Lenka, Safar, Jiri G., Westaway, David

“…Tau accumulation is a prominent feature in a variety of neurodegenerative disorders and remarkable effort has been expended working out the biochemistry and…”
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Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice by Eskandari-Sedighi, Ghazaleh, Crichton, Madeline, Zia, Sameera, Gomez-Cardona, Erik, Cortez, Leonardo M, Patel, Zain H, Takahashi-Yamashiro, Kei, St Laurent, Chris D, Sidhu, Gaurav, Sarkar, Susmita, Aghanya, Vivian, Sim, Valerie L, Tan, Qiumin, Julien, Olivier, Plemel, Jason R, Macauley, Matthew S

“…Microglia play diverse pathophysiological roles in Alzheimer's disease (AD), with genetic susceptibility factors skewing microglial cell function to influence…”
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Vitamin D and multiple sclerosis: a critical review and recommendations on treatment by Faridar, Alireza, Eskandari, Ghazaleh, Sahraian, Mohammad Ali, Minagar, Alireza, Azimi, Amirreza

“…Multiple sclerosis (MS) is an immune-mediated and degenerative disease of nervous system, which affects mostly young adults. Vitamin D deficiency is a…”
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Pathology Trainee Redeployment and Education During the COVID-19 Pandemic: An Institutional Experience by Monroig-Bosque, Paloma del C., Hsu, Jim W., Lin, Michelle S., Shehabeldin, Ahmed N., Rogers, John T., Kim, Charlotte F., Kalsekar, Ayaz G., Jin, Zhicheng, Cara, Lukas R., Barbieri, Andreia N., El-Zaatari, Ziad, Eskandari, Ghazaleh, Sheu, Tiffany G., Tomsula, Jessica A., Long, Scott W., Zieske, Arthur W., Leveque, Christopher M., Salazar, Eric, Mody, Dina R., Schwartz, Mary R., Cykowski, Matthew D., Yi, Xin, Powell, Suzanne Z., Thomas, Jessica S.

“…Pathology training programs throughout the United States have endured unprecedented challenges dealing with the ongoing coronavirus disease 2019 pandemic. At…”
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The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition by Eskandari-Sedighi, Ghazaleh, Daude, Nathalie, Gapeshina, Hristina, Sanders, David W, Kamali-Jamil, Razieh, Yang, Jing, Shi, Beipei, Wille, Holger, Ghetti, Bernardino, Diamond, Marc I, Janus, Christopher, Westaway, David

“…MAPT mutations cause neurodegenerative diseases such as frontotemporal dementia but, strikingly, patients with the same mutation may have different clinical…”
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Streamlined high-throughput cloning protocol to generate arrayed mutant libraries by Sun, Kerry T., Patel, Tark S., Kim, Justin, Tang, Helen S.H., Eskandari-Sedighi, Ghazaleh, Sureshkumar, Haresh, Schieve, Dean, Mok, S.A.

“…Large-scale, site-directed mutagenesis enables rapid characterization of the biochemical and biological properties of proteins. Here, we present a…”
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Chronic, Long-Term Social Stress Can Cause Decreased Microtubule Protein Network Activity and Dynamics in Cerebral Cortex of Male Wistar Rats by Eskandari Sedighi, Ghazaleh, Riazi, Gholam Hossein, Vaez Mahdavi, Mohammad Reza, Cheraghi, Tayebe, Atarod, Deyhim, Rafiei, Shahrbanoo

“…Social stress is viewed as a factor in the etiology of a variety of psychopathologies such as depression and anxiety. Animal models of social stress are well…”
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Quaternary Structure Changes for PrPSc Predate PrPC Downregulation and Neuronal Death During Progression of Experimental Scrapie Disease by Eskandari-Sedighi, Ghazaleh, Cortez, Leonardo M., Yang, Jing, Daude, Nathalie, Shmeit, Klinton, Sim, Valerie, Westaway, David

“…Prion diseases are fatal neurodegenerative diseases in mammals with the unique characteristics of misfolding and aggregation of the cellular prion protein (PrP…”
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Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation by Daude, Nathalie, Kim, Chae, Kang, Sang-Gyun, Eskandari-Sedighi, Ghazaleh, Haldiman, Tracy, Yang, Jing, Fleck, Shelaine C., Gomez-Cardona, Erik, Han, Zhuang Zhuang, Borrego-Ecija, Sergi, Wohlgemuth, Serene, Julien, Olivier, Wille, Holger, Molina-Porcel, Laura, Gelpi, Ellen, Safar, Jiri G., Westaway, David

“…Tau protein accumulation is a common denominator of major dementias, but this process is inhomogeneous, even when triggered by the same germline mutation. We…”
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Metabolomic study of disease progression in scrapie prion infected mice; validation of a novel method for brain metabolite extraction by Fu, Ze-Lin, Mercier, Pascal, Eskandari-Sedighi, Ghazaleh, Yang, Jing, Westaway, David, Sykes, Brian D.

“…Introduction Prion disease is a form of neurodegenerative disease caused by the misfolding and aggregation of cellular prion protein (PrP C ). The…”
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First-in-Man Phase I Trial of the Selective MET Inhibitor Tepotinib in Patients with Advanced Solid Tumors by Falchook, Gerald S, Kurzrock, Razelle, Amin, Hesham M, Xiong, Wenyuan, Fu, Siqing, Piha-Paul, Sarina A, Janku, Filip, Eskandari, Ghazaleh, Catenacci, Daniel V, Klevesath, Manfred, Bruns, Rolf, Stammberger, Uz, Johne, Andreas, Bladt, Friedhelm, Friese-Hamim, Manja, Girard, Pascal, El Bawab, Samer, Hong, David S

“…Tepotinib is an oral, potent, highly selective MET inhibitor. This first-in-man phase I trial investigated the MTD of tepotinib to determine the recommended…”
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S1252 Can a Single Decision-Making Support Tool Spare Inpatients From Inappropriate Testing for Nosocomial Diarrhea? by Abughazaleh, Shaadi J., Eskandari, Ghazaleh, Barahona, Lilian Vargas, Long, Scott, Ergun, Gulchin A.

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Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area by Long, S Wesley, Olsen, Randall J, Christensen, Paul A, Bernard, David W, Davis, James J, Shukla, Maulik, Nguyen, Marcus, Saavedra, Matthew Ojeda, Yerramilli, Prasanti, Pruitt, Layne, Subedi, Sishir, Kuo, Hung-Che, Hendrickson, Heather, Eskandari, Ghazaleh, Nguyen, Hoang A T, Long, J Hunter, Kumaraswami, Muthiah, Goike, Jule, Boutz, Daniel, Gollihar, Jimmy, McLellan, Jason S, Chou, Chia-Wei, Javanmardi, Kamyab, Finkelstein, Ilya J, Musser, James M

“…We sequenced the genomes of 5,085 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains causing two coronavirus disease 2019 (COVID-19) disease…”
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Validity and reliability of Persian version of Modified Fatigue Impact Scale (MFIS) questionnaire in Iranian patients with multiple sclerosis by Ghajarzadeh, Mahsa, Jalilian, Rozita, Eskandari, Ghazaleh, Ali Sahraian, Mohammad, Reza Azimi, Amir

“…Abstract Purpose: To determine the validity and reliability of the Persian version of the Modified Fatigue Impact Scale (MFIS) questionnaire for Iranian…”
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Frequent detection of CBFA2T3::GLIS2 fusion and RAM-phenotype in pediatric non-Down syndrome acute megakaryoblastic leukemia: a possible novel relationship with aberrant cytoplasmic CD3 expression by Chen Wongworawat, Yan, Eskandari, Ghazaleh, Gaikwad, Amos, Marcogliese, Andrea N., Ferguson, Lizmery S., Brackett, Julienne, Punia, Jyotinder N., Elghetany, M. Tarek, Kulkarni, Reshma, Rao, Pulivarthi H., Ringrose, Jo, Lopez-Terrada, Dolores H., Roy, Angshumoy, Curry, Choladda V., Fisher, Kevin E.

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