Search Results - "Eskandar, Emad N."

Mechanisms of deep brain stimulation by Herrington, Todd M, Cheng, Jennifer J, Eskandar, Emad N

“…Deep brain stimulation (DBS) is widely used for the treatment of movement disorders including Parkinson's disease, essential tremor, and dystonia and, to a…”
Get full text

Enhanced Dendritic Compartmentalization in Human Cortical Neurons by Beaulieu-Laroche, Lou, Toloza, Enrique H.S., van der Goes, Marie-Sophie, Lafourcade, Mathieu, Barnagian, Derrick, Williams, Ziv M., Eskandar, Emad N., Frosch, Matthew P., Cash, Sydney S., Harnett, Mark T.

“…The biophysical features of neurons shape information processing in the brain. Cortical neurons are larger in humans than in other species, but it is unclear…”
Get full text

Older Patients Have Better Pain Outcomes Following Microvascular Decompression for Trigeminal Neuralgia by Bick, Sarah K, Huie, David, Sneh, Gabriel, Eskandar, Emad N

“…Abstract BACKGROUND Trigeminal neuralgia (TN) increases in prevalence with age. Although microvascular decompression (MVD) is the most effective long-term…”
Get full text

A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression by Dougherty, Darin D, Rezai, Ali R, Carpenter, Linda L, Howland, Robert H, Bhati, Mahendra T, O’Reardon, John P, Eskandar, Emad N, Baltuch, Gordon H, Machado, Andre D, Kondziolka, Douglas, Cusin, Cristina, Evans, Karleyton C, Price, Lawrence H, Jacobs, Karen, Pandya, Mayur, Denko, Timothey, Tyrka, Audrey R, Brelje, Tim, Deckersbach, Thilo, Kubu, Cynthia, Malone, Donald A

“…Abstract Background Multiple open-label trials of deep brain stimulation (DBS) for treatment-resistant depression (TRD), including those targeting the ventral…”
Get full text

Cortical control of a tablet computer by people with paralysis by Nuyujukian, Paul, Albites Sanabria, Jose, Saab, Jad, Pandarinath, Chethan, Jarosiewicz, Beata, Blabe, Christine H, Franco, Brian, Mernoff, Stephen T, Eskandar, Emad N, Simeral, John D, Hochberg, Leigh R, Shenoy, Krishna V, Henderson, Jaimie M

“…General-purpose computers have become ubiquitous and important for everyday life, but they are difficult for people with paralysis to use. Specialized software…”
Get full text

Responsive Thalamic Neurostimulation: A Systematic Review of a Promising Approach for Refractory Epilepsy by Feigen, Chaim M., Eskandar, Emad N.

“…Introduction Responsive neurostimulation is an evolving therapeutic option for patients with treatment-refractory epilepsy. Open-loop, continuous stimulation…”
Get full text

Travelling spindles create necessary conditions for spike-timing-dependent plasticity in humans by Dickey, Charles W., Sargsyan, Anna, Madsen, Joseph R., Eskandar, Emad N., Cash, Sydney S., Halgren, Eric

“…Sleep spindles facilitate memory consolidation in the cortex during mammalian non-rapid eye movement sleep. In rodents, phase-locked firing during spindles may…”
Get full text

Encoding of both positive and negative reward prediction errors by neurons of the primate lateral prefrontal cortex and caudate nucleus by Asaad, Wael F, Eskandar, Emad N

“…Learning can be motivated by unanticipated success or unexpected failure. The former encourages us to repeat an action or activity, whereas the latter leads us…”
Get full text

Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness by Lewis, Laura D, Weiner, Veronica S, Mukamel, Eran A, Donoghue, Jacob A, Eskandar, Emad N, Madsen, Joseph R, Anderson, William S, Hochberg, Leigh R, Cash, Sydney S, Brown, Emery N, Purdon, Patrick L

“…The neurophysiological mechanisms by which anesthetic drugs cause loss of consciousness are poorly understood. Anesthetic actions at the molecular, cellular,…”
Get full text

Surgical Treatment of Trigeminal Neuralgia by Bick, Sarah K.B., MD, Eskandar, Emad N., MD

“…Trigeminal neuralgia is characterized by severe, episodic pain in the trigeminal nerve distribution. Medical therapy is the first line treatment. For patients…”
Get full text

Widespread ripples synchronize human cortical activity during sleep, waking, and memory recall by Dickey, Charles W, Verzhbinsky, Ilya A, Jiang, Xi, Rosen, Burke Q, Kajfez, Sophie, Stedelin, Brittany, Shih, Jerry J, Ben-Haim, Sharona, Raslan, Ahmed M, Eskandar, Emad N, Gonzalez-Martinez, Jorge, Cash, Sydney S, Halgren, Eric

“…Declarative memory encoding, consolidation, and retrieval require the integration of elements encoded in widespread cortical locations. The mechanism whereby…”
Get full text

Local and distant responses to single pulse electrical stimulation reflect different forms of connectivity by Crocker, Britni, Ostrowski, Lauren, Williams, Ziv M., Dougherty, Darin D., Eskandar, Emad N., Widge, Alik S., Chu, Catherine J., Cash, Sydney S., Paulk, Angelique C.

“…Measuring connectivity in the human brain involves innumerable approaches using both noninvasive (fMRI, EEG) and invasive (intracranial EEG or iEEG) recording…”
Get full text

Human seizures self-terminate across spatial scales via a critical transition by Kramer, Mark A., Truccolo, Wilson, Eden, Uri T., Lepage, Kyle Q., Hochberg, Leigh R., Eskandar, Emad N., Madsen, Joseph R., Lee, Jong W., Maheshwari, Atul, Halgren, Eric, Chu, Catherine J., Cash, Sydney S.

“…Why seizures spontaneously terminate remains an unanswered fundamental question of epileptology. Here we present evidence that seizures self-terminate via a…”
Get full text

Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression by Malone, Donald A, Dougherty, Darin D, Rezai, Ali R, Carpenter, Linda L, Friehs, Gerhard M, Eskandar, Emad N, Rauch, Scott L, Rasmussen, Steven A, Machado, Andre G, Kubu, Cynthia S, Tyrka, Audrey R, Price, Lawrence H, Stypulkowski, Paul H, Giftakis, Jonathon E, Rise, Mark T, Malloy, Paul F, Salloway, Stephen P, Greenberg, Benjamin D

“…Background We investigated the use of deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) for treatment refractory depression. Methods…”
Get full text

Individualized localization and cortical surface-based registration of intracranial electrodes by Dykstra, Andrew R., Chan, Alexander M., Quinn, Brian T., Zepeda, Rodrigo, Keller, Corey J., Cormier, Justine, Madsen, Joseph R., Eskandar, Emad N., Cash, Sydney S.

“…In addition to its widespread clinical use, the intracranial electroencephalogram (iEEG) is increasingly being employed as a tool to map the neural correlates…”
Get full text

AAV2- GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial by LeWitt, Peter A, Prof, Rezai, Ali R, Prof, Leehey, Maureen A, Prof, Ojemann, Steven G, MD, Flaherty, Alice W, MD, Eskandar, Emad N, MD, Kostyk, Sandra K, MD, Thomas, Karen, DO, Sarkar, Atom, MD, Siddiqui, Mustafa S, MD, Tatter, Stephen B, Prof, Schwalb, Jason M, MD, Poston, Kathleen L, MD, Henderson, Jaimie M, MD, Kurlan, Roger M, Prof, Richard, Irene H, MD, Van Meter, Lori, MS, Sapan, Christine V, PhD, During, Matthew J, Prof, Kaplitt, Michael G, MD, Feigin, Andrew, Dr

“…Summary Background Gene transfer of glutamic acid decarboxylase ( GAD ) and other methods that modulate production of GABA in the subthalamic nucleus improve…”
Get full text

Characterizing brain dynamics during ketamine-induced dissociation and subsequent interactions with propofol using human intracranial neurophysiology by Tian, Fangyun, Lewis, Laura D., Zhou, David W., Balanza, Gustavo A., Paulk, Angelique C., Zelmann, Rina, Peled, Noam, Soper, Daniel, Santa Cruz Mercado, Laura A., Peterfreund, Robert A., Aglio, Linda S., Eskandar, Emad N., Cosgrove, G. Rees, Williams, Ziv M., Richardson, R. Mark, Brown, Emery N., Akeju, Oluwaseun, Cash, Sydney S., Purdon, Patrick L.

“…Ketamine produces antidepressant effects in patients with treatment-resistant depression, but its usefulness is limited by its psychotropic side effects…”
Get full text

Spatiotemporal dynamics of neocortical excitation and inhibition during human sleep by Peyrache, Adrien, Dehghani, Nima, Eskandar, Emad N, Madsen, Joseph R, Anderson, William S, Donoghue, Jacob A, Hochberg, Leigh R, Halgren, Eric, Cash, Sydney S, Destexhe, Alain

“…Intracranial recording is an important diagnostic method routinely used in a number of neurological monitoring scenarios. In recent years, advancements in such…”
Get full text

A method for precisely timed, on-demand intracranial stimulation using the RNS device by Bader, Edward R., Boro, Alexis D., Killian, Nathaniel J., Eskandar, Emad N.

Get full text

A flexible software tool for temporally-precise behavioral control in Matlab by Asaad, Wael F., Eskandar, Emad N.

“…Systems and cognitive neuroscience depend on carefully designed and precisely implemented behavioral tasks to elicit the neural phenomena of interest. To…”
Get full text