Search Results - "Eshbach, Megan L."

Receptor-Mediated Endocytosis in the Proximal Tubule by Eshbach, Megan L, Weisz, Ora A

“…Cells lining the proximal tubule (PT) of the kidney are highly specialized for apical endocytosis of filtered proteins and small bioactive molecules from the…”
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Proximal tubule apical endocytosis is modulated by fluid shear stress via an mTOR-dependent pathway by Long, Kimberly R, Shipman, Katherine E, Rbaibi, Youssef, Menshikova, Elizabeth V, Ritov, Vladimir B, Eshbach, Megan L, Jiang, Yu, Jackson, Edwin K, Baty, Catherine J, Weisz, Ora A

“…Cells lining the proximal tubule (PT) have unique membrane specializations that are required to maintain the high-capacity ion transport and endocytic…”
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The transcriptome of the Didelphis virginiana opossum kidney OK proximal tubule cell line by Eshbach, Megan L, Sethi, Rahil, Avula, Raghunandan, Lamb, Janette, Hollingshead, Deborah J, Finegold, David N, Locker, Joseph D, Chandran, Uma R, Weisz, Ora A

“…The OK cell line derived from the kidney of a female opossum has proven to be a useful model in which to investigate the unique regulation of ion transport and…”
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Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease by Eshbach, Megan L, Kaur, Amandeep, Rbaibi, Youssef, Tejero, Jesús, Weisz, Ora A

“…Proximal tubule (PT) dysfunction, including tubular proteinuria, is a significant complication in young sickle cell disease (SCD) that can eventually lead to…”
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Characterization and phosphoproteomic analysis of a human immortalized podocyte model of Fabry disease generated using CRISPR/Cas9 technology by Pereira, Ester M, Labilloy, Anatália, Eshbach, Megan L, Roy, Ankita, Subramanya, Arohan R, Monte, Semiramis, Labilloy, Guillaume, Weisz, Ora A

“…Fabry nephropathy is a major cause of morbidity and premature death in patients with Fabry disease (FD), a rare X-linked lysosomal storage disorder. Gb3, the…”
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Small-Molecule Inhibitor of FosA Expands Fosfomycin Activity to Multidrug-Resistant Gram-Negative Pathogens by Tomich, Adam D, Klontz, Erik H, Deredge, Daniel, Barnard, John P, McElheny, Christi L, Eshbach, Megan L, Weisz, Ora A, Wintrode, Patrick, Doi, Yohei, Sundberg, Eric J, Sluis-Cremer, Nicolas

“…The spread of multidrug or extensively drug-resistant Gram-negative bacteria is a serious public health issue. There are too few new antibiotics in development…”
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Hemoglobin Inhibits Uptake of Filtered Proteins by Proximal Tubule Cells: Implications for Sickle Cell Disease and Vitamin D Status by Eshbach, Megan L., Kaur, Amandeep, Rbaibi, Youssef, Agarwal, Yash, Zhang, Qiangmin, Nolin, Thomas D., Tejero, Jesús, Weisz, Ora A.

“…Proximal tubule (PT) dysfunction, including tubular proteinuria, is a significant complication in sickle cell disease (SCD) that can eventually lead to chronic…”
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Exposure of proximal tubule cells to fluid shear stress alters transcription of metabolic pathway enzymes by Ren, Qidong, Eshbach, Megan L., Rittenhouse, Natalie L., Long, Kimberly R., Rbaibi, Youssef, Locker, Joseph, Poholek, Amanda C., Weisz, Ora A.

“…Cells lining the proximal tubule (PT) of the kidney are specialized for efficient recovery of ions, glucose, and proteins from the glomerular filtrate. Despite…”
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Assessing the Role of OCRL1 in Proximal Tubule Function in a Lowe Syndrome Cell Model by Eshbach, Megan L., Shipman, Katherine E., Raghavan, Venkatesan, Rbaibi, Youssef, Long, Kimberly R., Labilloy, Anatália, Baty, Catherine J., Weisz, Ora A.

“…Abstract only Lowe syndrome is an X‐linked recessive disorder caused by mutations in OCRL , which encodes the phosphatidylinositol 5′‐phosphatase OCRL1…”
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