Search Results - "Esfahani, Shiva Hadi"

Is Diminazene an Angiotensin-Converting Enzyme 2 (ACE2) Activator? Experimental Evidence and Implications by Esfahani, Shiva Hadi, Jayaraman, Srinidhi, Karamyan, Vardan T

“…Antiprotozoal veterinary drug diminazene aceturate (DIZE) has been proposed to be an angiotensin-converting enzyme 2 (ACE2) activator. Since then, DIZE was…”
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Challenges with the proposed ACE2 activation mechanism of diminazene aceturate by Esfahani, Shiva Hadi, Karamyan, Vardan T.

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Imidazole Bioisostere Activators of Endopeptidase Neurolysin with Enhanced Potency and Metabolic Stability by Rahman, Md. Shafikur, Hadi Esfahani, Shiva, Zhang, Yong, Queen, Aarfa, Aljarrah, Manar, Kandil, Haya, Baez, Andrew, Abbruscato, Thomas J., Karamyan, Vardan T., Trippier, Paul C.

“…The peptidase neurolysin (Nln) has been validated as a potential target for developing therapeutics for ischemic stroke (IS). Overexpression of Nln in a mouse…”
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Correction to “Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability” by Rahman, Md. Shafikur, Kumari, Shikha, Hadi Esfahani, Shiva, Nozohouri, Saeideh, Jayaraman, Srinidhi, Kinarivala, Nihar, Kocot, Joanna, Baez, Andrew, Farris, Delaney, Abbruscato, Thomas J, Karamyan, Vardan T, Trippier, Paul C

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Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals by Zhang, Yong, Sharma, Sejal, Jonnalagadda, Shirisha, Kumari, Shikha, Queen, Aarfa, Esfahani, Shiva Hadi, Archie, Sabrina Rahman, Nozohouri, Saeideh, Patel, Dhavalkumar, Trippier, Paul C., Karamyan, Vardan T., Abbruscato, Thomas J.

“…Purpose There is growing interest in seeking pharmacological activation of neurolysin (Nln) for stroke treatment. Discovery of central nervous system drugs…”
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In-Vivo and Ex-Vivo Brain Uptake Studies of Peptidomimetic Neurolysin Activators in Healthy and Stroke Animals by Nozohouri, Saeideh, Esfahani, Shiva Hadi, Noorani, Behnam, Patel, Dhaval, Villalba, Heidi, Ghanwatkar, Yashwardhan, Rahman, Md. Shafikur, Zhang, Yong, Bickel, Ulrich, Trippier, Paul C., Karamyan, Vardan T., Abbruscato, Thomas J.

“…Purpose Neurolysin (Nln) is a peptidase that functions to preserve the brain following ischemic stroke by hydrolyzing various neuropeptides. Nln activation has…”
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Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability by Rahman, Md. Shafikur, Kumari, Shikha, Esfahani, Shiva Hadi, Nozohouri, Saeideh, Jayaraman, Srinidhi, Kinarivala, Nihar, Kocot, Joanna, Baez, Andrew, Farris, Delaney, Abbruscato, Thomas J, Karamyan, Vardan T, Trippier, Paul C

“…Peptidase neurolysin (Nln) is an enzyme that functions to cleave various neuropeptides. Upregulation of Nln after stroke has identified the enzyme as a…”
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Small molecule neurolysin activators, potential multi-mechanism agents for ischemic stroke therapy by Esfahani, Shiva Hadi, Abbruscato, Thomas J, Trippier, Paul C, Karamyan, Vardan T

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Structure-activity relationship studies of functionalized aromatic peptidomimetics as neurolysin activators by Rahman, Md. Shafikur, Esfahani, Shiva Hadi, Nozohouri, Saeideh, Kumari, Shikha, Kocot, Joanna, Zhang, Yong, Abbruscato, Thomas J., Karamyan, Vardan T., Trippier, Paul C.

“…[Display omitted] Modulating peptidase neurolysin (Nln) has been identified as a potential cerebroprotective target for the development of therapeutics for…”
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Identification and Characterization of Two Structurally Related Dipeptides that Enhance Catalytic Efficiency of Neurolysin by Jayaraman, Srinidhi, Kocot, Joanna, Esfahani, Shiva Hadi, Wangler, Naomi J, Uyar, Arzu, Mechref, Yehia, Trippier, Paul C, Abbruscato, Thomas J, Dickson, Alex, Aihara, Hideki, Ostrov, David A, Karamyan, Vardan T

“…Neurolysin (Nln) is a recently recognized endogenous mechanism functioning to preserve the brain from ischemic injury. To further understand the…”
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