Search Results - "Escriba, Pablo V."

Corrigendum: Editorial: Metabolic modulation of cellular function by Kakhlon, Or, Saada, Ann, Escriba, Pablo V

“…[This corrects the article DOI: 10.3389/fcell.2024.1395922.]…”
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Editorial: Metabolic modulation of cellular function by Kakhlon, Or, Saada, Ann, Escriba, Pablo V

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Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity by Massalha, Wessal, Markovits, Mark, Pichinuk, Edward, Feinstein-Rotkopf, Yael, Tarshish, Mark, Mishra, Kumudesh, Llado, Victoria, Weil, Miguel, Escriba, Pablo V, Kakhlon, Or

“…This work tests bioenergetic and cell-biological implications of the synthetic fatty acid Minerval (2-hydroxyoleic acid), previously demonstrated to act by…”
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Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues by Casares, Doralicia, Escribá, Pablo V, Rosselló, Catalina Ana

“…Biological membranes are key elements for the maintenance of cell architecture and physiology. Beyond a pure barrier separating the inner space of the cell…”
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Editorial: Using Small Molecules to Treat Macromolecule Storage Disorders by Kakhlon, Or, Escriba, Pablo V, Akman, Hasan O, Weil, Miguel

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Multifaceted Analyses of Isolated Mitochondria Establish the Anticancer Drug 2-Hydroxyoleic Acid as an Inhibitor of Substrate Oxidation and an Activator of Complex IV-Dependent State 3 Respiration by Mishra, Kumudesh, Péter, Mária, Nardiello, Anna Maria, Keller, Guy, Llado, Victoria, Fernandez-Garcia, Paula, Kahlert, Ulf D, Barasch, Dinorah, Saada, Ann, Török, Zsolt, Balogh, Gábor, Escriba, Pablo V, Piotto, Stefano, Kakhlon, Or

“…The synthetic fatty acid 2-hydroxyoleic acid (2OHOA) has been extensively investigated as a cancer therapy mainly based on its regulation of membrane lipid…”
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Membrane-lipid therapy: A historical perspective of membrane-targeted therapies — From lipid bilayer structure to the pathophysiological regulation of cells by Escribá, Pablo V.

“…Our current understanding of membrane lipid composition, structure and functions has led to the investigation of their role in cell signaling, both in healthy…”
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The effect of natural and synthetic fatty acids on membrane structure, microdomain organization, cellular functions and human health by Ibarguren, Maitane, López, David J., Escribá, Pablo V.

“…This review deals with the effects of synthetic and natural fatty acids on the biophysical properties of membranes, and on their implication on cell function…”
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Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment by Escribá, Pablo V., Busquets, Xavier, Inokuchi, Jin-ichi, Balogh, Gábor, Török, Zsolt, Horváth, Ibolya, Harwood, John L., Vígh, László

“…Nowadays we understand cell membranes not as a simple double lipid layer but as a collection of complex and dynamic protein–lipid structures and microdomains…”
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Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy by Barceló-Coblijn, Gwendolyn, Martin, Maria Laura, de Almeida, Rodrigo F. M, Noguera-Salvà, Maria Antònia, Marcilla-Etxenike, Amaia, Guardiola-Serrano, Francisca, Lüth, Anja, Kleuser, Burhard, Halver, John E, Escribá, Pablo V

“…The mechanism of action of 2-hydroxyoleic acid (2OHOA), a potent antitumor compound, has not yet been fully elucidated. Here, we show that human cancer cells…”
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Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design by Froese, D Sean, Michaeli, Amit, McCorvie, Thomas J, Krojer, Tobias, Sasi, Meitav, Melaev, Esther, Goldblum, Amiram, Zatsepin, Maria, Lossos, Alexander, Álvarez, Rafael, Escribá, Pablo V, Minassian, Berge A, von Delft, Frank, Kakhlon, Or, Yue, Wyatt W

“…Glycogen branching enzyme 1 (GBE1) plays an essential role in glycogen biosynthesis by generating α-1,6-glucosidic branches from α-1,4-linked glucose chains,…”
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Antimicrobial activity, membrane interaction and structural features of short arginine-rich antimicrobial peptides by Agrillo, Bruna, Porritiello, Alessandra, Gratino, Lorena, Balestrieri, Marco, Proroga, Yolande Therese, Mancusi, Andrea, Cozzi, Loredana, Vicenza, Teresa, Dardano, Principia, Miranda, Bruno, Escribá, Pablo V., Gogliettino, Marta, Palmieri, Gianna

“…Antimicrobial activity of many AMPs can be improved by lysine-to-arginine substitution due to a more favourable interaction of arginine guanidinium moiety with…”
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The Antimicrobial Peptide 1018-K6 Interacts Distinctly with Eukaryotic and Bacterial Membranes, the Basis of Its Specificity and Bactericidal Activity by Ambrosio, Rosa Luisa, Rosselló, Catalina Ana, Casares, Doralicia, Palmieri, Gianna, Anastasio, Aniello, Escribá, Pablo V

“…Since penicillin was discovered, antibiotics have been critical in the fight against infections. However, antibiotic misuse has led to drug resistance, which…”
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Membrane-lipid therapy: a new approach in molecular medicine by Escribá, Pablo V.

“…Although most drugs bind to proteins and regulate their activity, some drugs act through a new therapeutic approach called membrane-lipid therapy and bind to…”
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Regulation of the cancer cell membrane lipid composition by NaCHOleate: effects on cell signaling and therapeutical relevance in glioma by Lladó, Victoria, López, David J, Ibarguren, Maitane, Alonso, María, Soriano, Joan B, Escribá, Pablo V, Busquets, Xavier

“…This review summarizes the cellular bases of the effects of NaCHOleate (2-hydroxyoleic acid; 2OHOA; Minerval) against glioma and other types of tumors…”
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A Phase 1/2A trial of idroxioleic acid: first-in-class sphingolipid regulator and glioma cell autophagy inducer with antitumor activity in refractory glioma by Lopez, Juanita, Lai-Kwon, Julia, Molife, Rhoda, Welsh, Liam, Tunariu, Nina, Roda, Desamparados, Fernández-García, Paula, Lladó, Victoria, McNicholl, Adrian G., Rosselló, Catalina A., Taylor, Richard J., Azaro, Analía, Rodón, Jordi, Sludden, Julieann, Veal, Gareth J., Plummer, Ruth, Urruticoechea, Ander, Lahuerta, Ainhara, Mujika, Karmele, Escribá, Pablo V.

“…Background The first-in-class brain-penetrating synthetic hydroxylated lipid idroxioleic acid (2-OHOA; sodium 2-hydroxyoleate), activates sphingomyelin…”
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Lipid–protein interactions in GPCR-associated signaling by Escribá, Pablo V., Wedegaertner, Philip B., Goñi, Félix M., Vögler, Oliver

“…Signal transduction via G-protein-coupled receptors (GPCRs) is a fundamental pathway through which the functions of an individual cell can be integrated within…”
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Fundamentals of Membrane Lipid Replacement: A Natural Medicine Approach to Repairing Cellular Membranes and Reducing Fatigue, Pain, and Other Symptoms While Restoring Function in Chronic Illnesses and Aging by Nicolson, Garth L, Ferreira de Mattos, Gonzalo, Ash, Michael, Settineri, Robert, Escribá, Pablo V

“…Membrane Lipid Replacement (MLR) uses natural membrane lipid supplements to safely replace damaged, oxidized lipids in membranes in order to restore membrane…”
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Targeting the Notch-Furin axis with 2-hydroxyoleic acid: a key mechanism in glioblastoma therapy by Rodríguez-Lorca, Raquel, Román, Ramón, Beteta-Göbel, Roberto, Torres, Manuel, Lladó, Victoria, Escribá, Pablo V, Fernández-García, Paula

“…Glioblastomas (GBMs) are highly treatment-resistant and aggressive brain tumors. 2OHOA, which is currently running a phase IIB/III clinical trial for newly…”
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2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy by Terés, Silvia, Lladó, Victoria, Higuera, Mónica, Barceló-Coblijn, Gwendolyn, Martin, Maria Laura, Noguera-Salvà, Maria Antònia, Marcilla-Etxenike, Amaia, García-Verdugo, José Manuel, Soriano-Navarro, Mario, Saus, Carlos, Gómez-Pinedo, Ulises, Busquets, Xavier, Escribá, Pablo V.

“…Despite recent advances in the development of new cancer therapies, the treatment options for glioma remain limited, and the survival rate of patients has…”
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