In vitro leishmanicidal and trypanocidal evaluation and magnetic properties of 7-amino-1,2,4-triazolo[1,5-a]pyrimidine Cu(II) complexes
Two triazolopyrimidine complexes have been obtained from reaction between 7-amino-1,2,4-triazolo[1,5-a]pyrimidine (7atp) and Cu (II) salts. Crystal structures of [Cu2(μ-7atp)4Cl2]Cl2·4H2O (1) and [Cu2(μ-7atp)4(H2O)2](NO3)4·H2O (2) have been studied by X-ray diffraction methods and characterized by s...
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| Published in: | Journal of inorganic biochemistry Vol. 180; pp. 26 - 32 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Elsevier Inc
01-03-2018
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| Online Access: | Get full text |
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| Summary: | Two triazolopyrimidine complexes have been obtained from reaction between 7-amino-1,2,4-triazolo[1,5-a]pyrimidine (7atp) and Cu (II) salts. Crystal structures of [Cu2(μ-7atp)4Cl2]Cl2·4H2O (1) and [Cu2(μ-7atp)4(H2O)2](NO3)4·H2O (2) have been studied by X-ray diffraction methods and characterized by spectroscopic and thermal analysis. Magnetic studies of these dinuclear complexes have revealed the existence of moderate antiferromagnetic interactions between the copper ions, with J values of −91.2 and −96.1cm−1 respectively. It must be highlighted that the antiparasitic activity of these new complexes has been studied in vitro against three different strains of leishmania spp. and Trypanosoma cruzi, showing a higher efficacy than the 7atp ligand and the reference commercial drugs.
Two dinuclear copper (II) complexes using triazolopyrimidine derivative 7-amino-1,2,4-triazolo[1,5-a]pyrimidine (7atp) as ligand have been synthesized. Both compounds have been characterized by spectroscopic and thermal analysis and X-ray diffraction. Magnetic properties have been studied and antiparasitic activity against Trypanosomatidae family strains has been assayed, showing higher efficacy than the reference drugs. [Display omitted]
•Two dinuclear Cu (II) triazolopyrimidine complexes have been synthesized and characterized.•Magnetic properties of both compounds have been studied.•Antiparasitic activity has been assayed against three leishmania strains and T. cruzi.•Clearly superior antiparasitic efficacy in comparison with reference drugs was demonstrate. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0162-0134 1873-3344 |
| DOI: | 10.1016/j.jinorgbio.2017.11.027 |