Search Results - "Escobedo, J A"

Retinal Degeneration Is Slowed in Transgenic Rats by AAV-Mediated Delivery of FGF-2 by Lau, Dana, McGee, Laura H, Zhou, Shangzhen, Rendahl, Katherine G, Manning, William C, Escobedo, Jaime A, Flannery, John G

“…We evaluated adeno-associated virus (AAV)-mediated gene transfer of basic fibroblast growth factor (FGF-2) as a therapy for photoreceptor degeneration in a…”
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The fms-Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor by De Vries, Carlie, Escobedo, Jaime A., Ueno, Hikaru, Houck, Keith, Ferrara, Napoleone, Williams, Lewis T.

“…The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt complementary DNA in COS cells conferred…”
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Adeno-associated virus-mediated delivery of erythropoietin leads to sustained elevation of hematocrit in nonhuman primates by ZHOU, S, MURPHY, J. E, ESCOBEDO, J. A, DWARKI, V. J

“…Recombinant adeno-associated virus encoding the monkey erythropoietin gene (rAAV-cm-Epo) was generated and tested for its potential to confer long-term…”
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Genetic immunization with adeno-associated virus vectors expressing herpes simplex virus type 2 glycoproteins B and D by Manning, W C, Paliard, X, Zhou, S, Pat Bland, M, Lee, A Y, Hong, K, Walker, C M, Escobedo, J A, Dwarki, V

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Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways by Fantl, W J, Escobedo, J A, Martin, G A, Turck, C W, del Rosario, M, McCormick, F, Williams, L T

“…The receptor for platelet-derived growth factor (PDGF) binds two proteins containing SH2 domains, GTPase activating protein (GAP) and phosphatidylinositol…”
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Regulation of chemotaxis by the platelet-derived growth factor receptor-β by Kundra, Vikas, Escobedo, Jaime A, Kazlauskas, Andrius, Kim, Ha Kun, Rhee, Sue Goo, Williams, Lewis T, Zetter, Bruce R

“…Chemotaxis is an important component of wound healing, development, immunity and metastasis, yet the signalling pathways that mediate chemotaxis are poorly…”
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A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine by ESCOBEDO, J. A, KAPLAN, D. R, KAVANAUGH, W. M, TURCK, C. W>, WILLIAMS, L. T

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The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity by KLIPPEL, A, ESCOBEDO, J. A, HIRANO, M, WILLIAMS, L. T

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Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors by Yarden, Y, Escobedo, J. A, Kuang, W-J, Yang-Feng, T. L, Daniel, T. O, Tremble, P. M, Chen, E. Y, Ando, M. E, Harkins, R. N, Francke, U, Fried, V. A, Ullrich, A, Williams, L. T

“…The primary structure of the receptor for platelet-derived growth factor (PDGF), determined by means of cloning a cDNA that encodes the murine pre-PDGF…”
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The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor by KLIPPEL, A, ESCOBEDO, J. A, FANTL, W. J, WILLIAMS, L. T

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A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo by Klippel, A, Escobedo, J A, Hu, Q, Williams, L T

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Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types by SATOH, T, FANTL, W. J, ESCOBEDO, J. A, WILLIAMS, L. T, KAZIRO, Y

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Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction by Coughlin, Shaun R., Escobedo, Jaime A., Williams, Lewis T.

“…The molecules with which the platelet-derived growth factor (PDGF) receptor interacts to elicit the biochemical reactions responsible for cell proliferation…”
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Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor by Morrison, D K, Kaplan, D R, Escobedo, J A, Rapp, U R, Roberts, T M, Williams, L T

“…We have examined the interaction between the serine/threonine kinase proto-oncogene product Raf-1 and the tyrosine kinase PDGF beta-receptor. Raf-1 tyrosine…”
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Cardiac Myocyte Hypertrophy is Associated with c-myc Protooncogene Expression by Starksen, Niel F., Simpson, Paul C., Bishopric, Nannette, Coughlin, Shaun R., William M. F. Lee, Escobedo, Jaime A., Williams, Lewis T.

“…The mechanism of hormonally induced cell hypertrophy is unknown. Stimulation of cardiac myocytes by α1-adrenergic agents, phorbol esters, and serum induces an…”
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Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways by Kinashi, T, Escobedo, J A, Williams, L T, Takatsu, K, Springer, T A

“…Receptor tyrosine kinases are known to be important in growth and differentiation. We have recently found that c-kit, the tyrosine kinase receptor for steel…”
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Role of tyrosine kinase and membrane-spanning domains in signal transduction by the platelet-derived growth factor receptor by ESCOBEDO, J. A, BARR, P. J, WILLIAMS, L. T

“…Correction ( vol. 10 , p. 3858 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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Modification of the 85-kilodalton subunit of phosphatidylinositol-3 kinase in platelet-derived growth factor-stimulated cells by MICHAEL KAVANAUGH, W, KLIPPEL, A, ESCOBEDO, J. A, WILLIAMS, L. T

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Inhibition of PDGF β Receptor Signal Transduction by Coexpression of a Truncated Receptor by Ueno, Hikaru, Colbert, Heather, Escobedo, Jaime A., Williams, Lewis T.

“…A mutated form of the platelet-derived growth factor (PDGF) β receptor lacking most of its cytoplasmic domain was tested for its ability to block wild-type…”
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Angiotensin II type 1 receptor signals through Raf-1 by a protein kinase C-dependent, Ras-independent mechanism by Arai, H, Escobedo, J A

“…To understand the molecular mechanism by which the angiotensin II (AII) type 1 receptor (AT1 receptor) transduces its biological signal, we examined the role…”
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