Search Results - "Esch, J."

Transmission and Epidemiology of Zoonotic Protozoal Diseases of Companion Animals by ESCH, Kevin J, PETERSEN, Christine A

“…Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

KLIFS: an overhaul after the first 5 years of supporting kinase research by Kanev, Georgi K, de Graaf, Chris, Westerman, Bart A, de Esch, Iwan J P, Kooistra, Albert J

“…Abstract Kinases are a prime target of drug development efforts with >60 drug approvals in the past two decades. Due to the research into this protein family,…”
Get full text

Fragment-to-Lead Medicinal Chemistry Publications in 2020 by de Esch, Iwan J. P, Erlanson, Daniel A, Jahnke, Wolfgang, Johnson, Christopher N, Walsh, Louise

“…Fragment-based drug discovery (FBDD) continues to evolve and make an impact in the pharmaceutical sciences. We summarize successful fragment-to-lead studies…”
Get full text

KLIFS: A Knowledge-Based Structural Database To Navigate Kinase–Ligand Interaction Space by van Linden, Oscar P. J., Kooistra, Albert J., Leurs, Rob, de Esch, Iwan J. P., de Graaf, Chris

“…Protein kinases regulate the majority of signal transduction pathways in cells and have become important targets for the development of designer drugs. We…”
Get full text

Fragment-to-Lead Medicinal Chemistry Publications in 2018 by Erlanson, Daniel A, de Esch, Iwan J. P, Jahnke, Wolfgang, Johnson, Christopher N, Mortenson, Paul N

“…This Perspective, the fourth in an annual series, summarizes fragment-to-lead (F2L) success stories published during 2018. Topics such as target class,…”
Get full text

In situ liver transection with portal vein ligation for rapid growth of the future liver remnant in two-stage liver resection by Knoefel, W. T., Gabor, I., Rehders, A., Alexander, A., Krausch, M., Schulte am Esch, J., Fürst, G., Topp, S. A.

“…Background: Portal vein embolization (PVE) has become a standard procedure to increase the future liver remnant (FLR) and enable curative resection of…”
Get full text

Structural Analysis of Chemokine Receptor–Ligand Interactions by Arimont, Marta, Sun, Shan-Liang, Leurs, Rob, Smit, Martine, de Esch, Iwan J. P, de Graaf, Chris

“…This review focuses on the construction and application of structural chemokine receptor models for the elucidation of molecular determinants of chemokine…”
Get full text

Direction Selectivity in Drosophila Emerges from Preferred-Direction Enhancement and Null-Direction Suppression by Leong, Jonathan Chit Sing, Esch, Jennifer Judson, Poole, Ben, Ganguli, Surya, Clandinin, Thomas Robert

“…Across animal phyla, motion vision relies on neurons that respond preferentially to stimuli moving in one, preferred direction over the opposite, null…”
Get full text

Fragment-to-Lead Medicinal Chemistry Publications in 2019 by Jahnke, Wolfgang, Erlanson, Daniel A, de Esch, Iwan J. P, Johnson, Christopher N, Mortenson, Paul N, Ochi, Yuji, Urushima, Tatsuya

“…Fragment-based drug discovery (FBDD) has grown and matured to a point where it is valuable to keep track of its extent and details of application. This…”
Get full text

Transoral thyroidectomy: new method with new complications’ spectrum by Benhidjeb, T., Witzel, K., Stark, M., Schulte am Esch, J.

Get full text

Micro-foundations of dynamic capabilities to facilitate university technology transfer by Ma, Zhongxuan, Augustijn, K D, De Esch, I J P, Bossink, B A G

“…Within the university-industry ecosystem, improvement and innovation of technology transfer involve implementing appropriate dynamic capabilities. To answer…”
Get full text

Aminergic GPCR–Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data by Vass, Márton, Podlewska, Sabina, de Esch, Iwan J. P, Bojarski, Andrzej J, Leurs, Rob, Kooistra, Albert J, de Graaf, Chris

“…The aminergic family of G protein-coupled receptors (GPCRs) plays an important role in various diseases and represents a major drug discovery target class…”
Get full text

Predicting the target landscape of kinase inhibitors using 3D convolutional neural networks by Kanev, Georgi K, Zhang, Yaran, Kooistra, Albert J, Bender, Andreas, Leurs, Rob, Bailey, David, Würdinger, Thomas, de Graaf, Chris, de Esch, Iwan J. P, Westerman, Bart A

“…Many therapies in clinical trials are based on single drug-single target relationships. To further extend this concept to multi-target approaches using…”
Get full text

Bio-inspired supramolecular materials by orthogonal self-assembly of hydrogelators and phospholipids by Boekhoven, J, Brizard, A M, Stuart, M C A, Florusse, L, Raffy, G, Del Guerzo, A, van Esch, J H

“…The orthogonal self-assembly of multiple components is a powerful strategy towards the formation of complex biomimetic architectures, but so far the rules for…”
Get full text

PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design by Jansen, Chimed, Kooistra, Albert J, Kanev, Georgi K, Leurs, Rob, de Esch, Iwan J. P, de Graaf, Chris

“…A systematic analysis is presented of the 220 phosphodiesterase (PDE) catalytic domain crystal structures present in the Protein Data Bank (PDB) with a focus…”
Get full text

When a dying patient is asked to participate in a double-blind, placebo-controlled clinical trial on symptom control: The decision-making process and experiences of relatives by van Esch, Harriëtte J, Stoppelenburg, Arianne, van Zuylen, Lia, van der Rijt, Carin CD, van der Heide, Agnes

“…Background: Placebo-controlled trials can provide evidence to inform end-of-life care, but it is contested whether asking dying patients to participate in such…”
Get full text

Effect of Prophylactic Subcutaneous Scopolamine Butylbromide on Death Rattle in Patients at the End of Life: The SILENCE Randomized Clinical Trial by van Esch, Harriëtte J, van Zuylen, Lia, Geijteman, Eric C. T, Oomen-de Hoop, Esther, Huisman, Bregje A. A, Noordzij-Nooteboom, Heike S, Boogaard, Renske, van der Heide, Agnes, van der Rijt, Carin C. D

“…IMPORTANCE: Death rattle, defined as noisy breathing caused by the presence of mucus in the respiratory tract, is relatively common among dying patients…”
Get full text

Green Drug Discovery: Novel Fragment Space from the Biomass-Derived Molecule Dihydrolevoglucosenone (Cyrene TM ) by Dekker, Tom, Harteveld, Jaap W, Wágner, Gábor, de Vries, Max C M, Custers, Hans, van de Stolpe, Andrea C, de Esch, Iwan J P, Wijtmans, Maikel

“…Biomass-derived molecules can provide a basis for sustainable drug discovery. However, their full exploration is hampered by the dominance of millions of…”
Get full text

Neoantigen immunogenicity landscapes and evolution of tumor ecosystems during immunotherapy with nivolumab by Alban, Tyler J., Riaz, Nadeem, Parthasarathy, Prerana, Makarov, Vladimir, Kendall, Sviatoslav, Yoo, Seong-Keun, Shah, Rachna, Weinhold, Nils, Srivastava, Raghvendra, Ma, Xiaoxiao, Krishna, Chirag, Mok, Juk Yee, van Esch, Wim J. E., Garon, Edward, Akerley, Wallace, Creelan, Benjamin, Aanur, Nivedita, Chowell, Diego, Geese, William J., Rizvi, Naiyer A., Chan, Timothy A.

“…Neoantigen immunoediting drives immune checkpoint blockade efficacy, yet the molecular features of neoantigens and how neoantigen immunogenicity shapes…”
Get full text

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines by Spurny, Radovan, Ramerstorfer, Joachim, Price, Kerry, Brams, Marijke, Ernst, Margot, Nury, Hugues, Verheij, Mark, Legrand, Pierre, Bertrand, Daniel, Bertrand, Sonia, Dougherty, Dennis A, de Esch, Iwan J. P, Corringer, Pierre-Jean, Sieghart, Werner, Lummis, Sarah C. R, Ulens, Chris

“…GABA A receptors are pentameric ligand-gated ion channels involved in fast inhibitory neurotransmission and are allosterically modulated by the anxiolytic,…”
Get full text