Search Results - "Esch, J"

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  1. 1

    Transmission and Epidemiology of Zoonotic Protozoal Diseases of Companion Animals by ESCH, Kevin J, PETERSEN, Christine A

    Published in Clinical Microbiology Reviews (01-01-2013)
    “…Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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    KLIFS: an overhaul after the first 5 years of supporting kinase research by Kanev, Georgi K, de Graaf, Chris, Westerman, Bart A, de Esch, Iwan J P, Kooistra, Albert J

    Published in Nucleic acids research (08-01-2021)
    “…Abstract Kinases are a prime target of drug development efforts with >60 drug approvals in the past two decades. Due to the research into this protein family,…”
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    Fragment-to-Lead Medicinal Chemistry Publications in 2020 by de Esch, Iwan J. P, Erlanson, Daniel A, Jahnke, Wolfgang, Johnson, Christopher N, Walsh, Louise

    Published in Journal of medicinal chemistry (13-01-2022)
    “…Fragment-based drug discovery (FBDD) continues to evolve and make an impact in the pharmaceutical sciences. We summarize successful fragment-to-lead studies…”
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    KLIFS: A Knowledge-Based Structural Database To Navigate Kinase–Ligand Interaction Space by van Linden, Oscar P. J., Kooistra, Albert J., Leurs, Rob, de Esch, Iwan J. P., de Graaf, Chris

    Published in Journal of medicinal chemistry (23-01-2014)
    “…Protein kinases regulate the majority of signal transduction pathways in cells and have become important targets for the development of designer drugs. We…”
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    Fragment-to-Lead Medicinal Chemistry Publications in 2018 by Erlanson, Daniel A, de Esch, Iwan J. P, Jahnke, Wolfgang, Johnson, Christopher N, Mortenson, Paul N

    Published in Journal of medicinal chemistry (14-05-2020)
    “…This Perspective, the fourth in an annual series, summarizes fragment-to-lead (F2L) success stories published during 2018. Topics such as target class,…”
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    In situ liver transection with portal vein ligation for rapid growth of the future liver remnant in two-stage liver resection by Knoefel, W. T., Gabor, I., Rehders, A., Alexander, A., Krausch, M., Schulte am Esch, J., Fürst, G., Topp, S. A.

    Published in British journal of surgery (01-02-2013)
    “…Background: Portal vein embolization (PVE) has become a standard procedure to increase the future liver remnant (FLR) and enable curative resection of…”
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    Structural Analysis of Chemokine Receptor–Ligand Interactions by Arimont, Marta, Sun, Shan-Liang, Leurs, Rob, Smit, Martine, de Esch, Iwan J. P, de Graaf, Chris

    Published in Journal of medicinal chemistry (22-06-2017)
    “…This review focuses on the construction and application of structural chemokine receptor models for the elucidation of molecular determinants of chemokine…”
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  8. 8

    Direction Selectivity in Drosophila Emerges from Preferred-Direction Enhancement and Null-Direction Suppression by Leong, Jonathan Chit Sing, Esch, Jennifer Judson, Poole, Ben, Ganguli, Surya, Clandinin, Thomas Robert

    Published in The Journal of neuroscience (03-08-2016)
    “…Across animal phyla, motion vision relies on neurons that respond preferentially to stimuli moving in one, preferred direction over the opposite, null…”
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    Fragment-to-Lead Medicinal Chemistry Publications in 2019 by Jahnke, Wolfgang, Erlanson, Daniel A, de Esch, Iwan J. P, Johnson, Christopher N, Mortenson, Paul N, Ochi, Yuji, Urushima, Tatsuya

    Published in Journal of medicinal chemistry (24-12-2020)
    “…Fragment-based drug discovery (FBDD) has grown and matured to a point where it is valuable to keep track of its extent and details of application. This…”
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    Micro-foundations of dynamic capabilities to facilitate university technology transfer by Ma, Zhongxuan, Augustijn, K D, De Esch, I J P, Bossink, B A G

    Published in PloS one (30-03-2023)
    “…Within the university-industry ecosystem, improvement and innovation of technology transfer involve implementing appropriate dynamic capabilities. To answer…”
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    Aminergic GPCR–Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data by Vass, Márton, Podlewska, Sabina, de Esch, Iwan J. P, Bojarski, Andrzej J, Leurs, Rob, Kooistra, Albert J, de Graaf, Chris

    Published in Journal of medicinal chemistry (25-04-2019)
    “…The aminergic family of G protein-coupled receptors (GPCRs) plays an important role in various diseases and represents a major drug discovery target class…”
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  13. 13

    Predicting the target landscape of kinase inhibitors using 3D convolutional neural networks by Kanev, Georgi K, Zhang, Yaran, Kooistra, Albert J, Bender, Andreas, Leurs, Rob, Bailey, David, Würdinger, Thomas, de Graaf, Chris, de Esch, Iwan J. P, Westerman, Bart A

    Published in PLoS computational biology (05-09-2023)
    “…Many therapies in clinical trials are based on single drug-single target relationships. To further extend this concept to multi-target approaches using…”
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  14. 14

    Bio-inspired supramolecular materials by orthogonal self-assembly of hydrogelators and phospholipids by Boekhoven, J, Brizard, A M, Stuart, M C A, Florusse, L, Raffy, G, Del Guerzo, A, van Esch, J H

    Published in Chemical science (Cambridge) (01-01-2016)
    “…The orthogonal self-assembly of multiple components is a powerful strategy towards the formation of complex biomimetic architectures, but so far the rules for…”
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    PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design by Jansen, Chimed, Kooistra, Albert J, Kanev, Georgi K, Leurs, Rob, de Esch, Iwan J. P, de Graaf, Chris

    Published in Journal of medicinal chemistry (11-08-2016)
    “…A systematic analysis is presented of the 220 phosphodiesterase (PDE) catalytic domain crystal structures present in the Protein Data Bank (PDB) with a focus…”
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  16. 16

    When a dying patient is asked to participate in a double-blind, placebo-controlled clinical trial on symptom control: The decision-making process and experiences of relatives by van Esch, Harriëtte J, Stoppelenburg, Arianne, van Zuylen, Lia, van der Rijt, Carin CD, van der Heide, Agnes

    Published in Palliative medicine (01-12-2022)
    “…Background: Placebo-controlled trials can provide evidence to inform end-of-life care, but it is contested whether asking dying patients to participate in such…”
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    Green Drug Discovery: Novel Fragment Space from the Biomass-Derived Molecule Dihydrolevoglucosenone (Cyrene TM ) by Dekker, Tom, Harteveld, Jaap W, Wágner, Gábor, de Vries, Max C M, Custers, Hans, van de Stolpe, Andrea C, de Esch, Iwan J P, Wijtmans, Maikel

    Published in Molecules (Basel, Switzerland) (13-02-2023)
    “…Biomass-derived molecules can provide a basis for sustainable drug discovery. However, their full exploration is hampered by the dominance of millions of…”
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