Search Results - "Esch, J"
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Transmission and Epidemiology of Zoonotic Protozoal Diseases of Companion Animals
Published in Clinical Microbiology Reviews (01-01-2013)“…Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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KLIFS: an overhaul after the first 5 years of supporting kinase research
Published in Nucleic acids research (08-01-2021)“…Abstract Kinases are a prime target of drug development efforts with >60 drug approvals in the past two decades. Due to the research into this protein family,…”
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3
Fragment-to-Lead Medicinal Chemistry Publications in 2020
Published in Journal of medicinal chemistry (13-01-2022)“…Fragment-based drug discovery (FBDD) continues to evolve and make an impact in the pharmaceutical sciences. We summarize successful fragment-to-lead studies…”
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4
KLIFS: A Knowledge-Based Structural Database To Navigate Kinase–Ligand Interaction Space
Published in Journal of medicinal chemistry (23-01-2014)“…Protein kinases regulate the majority of signal transduction pathways in cells and have become important targets for the development of designer drugs. We…”
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Fragment-to-Lead Medicinal Chemistry Publications in 2018
Published in Journal of medicinal chemistry (14-05-2020)“…This Perspective, the fourth in an annual series, summarizes fragment-to-lead (F2L) success stories published during 2018. Topics such as target class,…”
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6
In situ liver transection with portal vein ligation for rapid growth of the future liver remnant in two-stage liver resection
Published in British journal of surgery (01-02-2013)“…Background: Portal vein embolization (PVE) has become a standard procedure to increase the future liver remnant (FLR) and enable curative resection of…”
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7
Structural Analysis of Chemokine Receptor–Ligand Interactions
Published in Journal of medicinal chemistry (22-06-2017)“…This review focuses on the construction and application of structural chemokine receptor models for the elucidation of molecular determinants of chemokine…”
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8
Direction Selectivity in Drosophila Emerges from Preferred-Direction Enhancement and Null-Direction Suppression
Published in The Journal of neuroscience (03-08-2016)“…Across animal phyla, motion vision relies on neurons that respond preferentially to stimuli moving in one, preferred direction over the opposite, null…”
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Fragment-to-Lead Medicinal Chemistry Publications in 2019
Published in Journal of medicinal chemistry (24-12-2020)“…Fragment-based drug discovery (FBDD) has grown and matured to a point where it is valuable to keep track of its extent and details of application. This…”
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10
Transoral thyroidectomy: new method with new complications’ spectrum
Published in Journal of endocrinological investigation (01-12-2019)Get full text
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11
Micro-foundations of dynamic capabilities to facilitate university technology transfer
Published in PloS one (30-03-2023)“…Within the university-industry ecosystem, improvement and innovation of technology transfer involve implementing appropriate dynamic capabilities. To answer…”
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12
Aminergic GPCR–Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data
Published in Journal of medicinal chemistry (25-04-2019)“…The aminergic family of G protein-coupled receptors (GPCRs) plays an important role in various diseases and represents a major drug discovery target class…”
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Predicting the target landscape of kinase inhibitors using 3D convolutional neural networks
Published in PLoS computational biology (05-09-2023)“…Many therapies in clinical trials are based on single drug-single target relationships. To further extend this concept to multi-target approaches using…”
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14
Bio-inspired supramolecular materials by orthogonal self-assembly of hydrogelators and phospholipids
Published in Chemical science (Cambridge) (01-01-2016)“…The orthogonal self-assembly of multiple components is a powerful strategy towards the formation of complex biomimetic architectures, but so far the rules for…”
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PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design
Published in Journal of medicinal chemistry (11-08-2016)“…A systematic analysis is presented of the 220 phosphodiesterase (PDE) catalytic domain crystal structures present in the Protein Data Bank (PDB) with a focus…”
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When a dying patient is asked to participate in a double-blind, placebo-controlled clinical trial on symptom control: The decision-making process and experiences of relatives
Published in Palliative medicine (01-12-2022)“…Background: Placebo-controlled trials can provide evidence to inform end-of-life care, but it is contested whether asking dying patients to participate in such…”
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Effect of Prophylactic Subcutaneous Scopolamine Butylbromide on Death Rattle in Patients at the End of Life: The SILENCE Randomized Clinical Trial
Published in JAMA : the journal of the American Medical Association (05-10-2021)“…IMPORTANCE: Death rattle, defined as noisy breathing caused by the presence of mucus in the respiratory tract, is relatively common among dying patients…”
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Green Drug Discovery: Novel Fragment Space from the Biomass-Derived Molecule Dihydrolevoglucosenone (Cyrene TM )
Published in Molecules (Basel, Switzerland) (13-02-2023)“…Biomass-derived molecules can provide a basis for sustainable drug discovery. However, their full exploration is hampered by the dominance of millions of…”
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Neoantigen immunogenicity landscapes and evolution of tumor ecosystems during immunotherapy with nivolumab
Published in Nature medicine (30-09-2024)“…Neoantigen immunoediting drives immune checkpoint blockade efficacy, yet the molecular features of neoantigens and how neoantigen immunogenicity shapes…”
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Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines
Published in Proceedings of the National Academy of Sciences - PNAS (30-10-2012)“…GABA A receptors are pentameric ligand-gated ion channels involved in fast inhibitory neurotransmission and are allosterically modulated by the anxiolytic,…”
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