Search Results - "Escate, Rafael"
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Systems Biology in Chronic Heart Failure-Identification of Potential miRNA Regulators
Published in International journal of molecular sciences (03-12-2022)“…Heart failure (HF) is a complex disease entity with high clinical impact, poorly understood pathophysiology and scantly known miRNA-mediated epigenetic…”
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Alternative C3 Complement System: Lipids and Atherosclerosis
Published in International journal of molecular sciences (12-05-2021)“…Familial hypercholesterolemia (FH) is increasingly associated with inflammation, a phenotype that persists despite treatment with lipid lowering therapies. The…”
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Moderate Beer Intake Downregulates Inflammasome Pathway Gene Expression in Human Macrophages
Published in Biology (Basel, Switzerland) (09-11-2021)“…Inflammasomes are key components of the innate immunity system that trigger the inflammatory response. Inappropriate activity of the inflammasome system has…”
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High miR-133a levels in the circulation anticipates presentation of clinical events in familial hypercholesterolaemia patients
Published in Cardiovascular research (01-01-2021)“…Presentation of acute events in patients with atherosclerosis remains unpredictable even after controlling for classical risk factors. MicroRNAs (miRNAs)…”
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miR‐505‐3p controls chemokine receptor up‐regulation in macrophages: role in familial hypercholesterolemia
Published in The FASEB journal (01-02-2018)“…Familial hypercholesterolemia (FH) conveys a high risk of premature atherosclerosis as a result of lifelong exposure to high LDL cholesterol levels that are…”
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High-density lipoprotein remodelled in hypercholesterolaemic blood induce epigenetically driven down-regulation of endothelial HIF-1α expression in a preclinical animal model
Published in Cardiovascular research (01-06-2020)“…Abstract Aims High-density lipoproteins (HDLs) are circulating micelles that transport proteins, lipids, and miRNAs. HDL-transported miRNAs (HDL-miRNAs) have…”
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Circulating miR-6821-5p levels and coronary calcification in asymptomatic familial hypercholesterolemia patients
Published in Atherosclerosis (01-05-2024)“…Premature atherosclerotic cardiovascular disease (CVD) is a clinic characteristic of familial hypercholesterolemia (FH). Coronary calcium score (CCS) is a…”
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Detrimental Effect of Hypercholesterolemia on High-Density Lipoprotein Particle Remodeling in Pigs
Published in Journal of the American College of Cardiology (11-07-2017)“…Beneficial effects of high-density lipoproteins (HDL) seem altered in patients with symptomatic cardiovascular disease. We recently demonstrated in a swine…”
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miR-505-3p controls chemokine receptor up-regulation in macrophages: role in familial hypercholesterolemia
Published in The FASEB journal (01-02-2018)“…Familial hypercholesterolemia (FH) conveys a high risk of premature atherosclerosis as a result of lifelong exposure to high LDL cholesterol levels that are…”
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10
miR‐619‐5p and cardiogenic shock in patients with ST‐segment elevation myocardial infarction
Published in European journal of clinical investigation (01-08-2024)“…Background Cardiogenic shock (CS) is a severe myocardial dysfunction secondary to various cardiac conditions including ST‐segment elevation acute myocardial…”
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Macrophages of genetically characterized familial hypercholesterolaemia patients show up‐regulation of LDL‐receptor‐related proteins
Published in Journal of cellular and molecular medicine (01-03-2017)“…Familial hypercholesterolaemia (FH) is a major risk for premature coronary heart disease due to severe long‐life exposure to high LDL levels. Accumulation of…”
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12
miR-505-3p controls chemokine receptor up-regulation in macrophages: role in familial hypercholesterolemia
Published in The FASEB journal (04-01-2018)“…Familial hypercholesterolemia (FH) conveys a high risk of premature atherosclerosis as a result of lifelong exposure to high LDL cholesterol levels that are…”
Get full text
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