Search Results - "Escalona, Jorge Cuenca"

PGE2‐EP4 signaling steers cDC2 maturation toward the induction of suppressive T‐cell responses by Cuenca‐Escalona, Jorge, Flórez‐Grau, Georgina, den Dries, Koen, Cambi, Alessandra, Vries, I. Jolanda M.

“…Dendritic cells (DCs) shape adaptive immunity in response to environmental cues such as cytokines or lipid mediators, including prostaglandin E2 (PGE2). In…”
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cDC2 plasticity and acquisition of a DC3‐like phenotype mediated by IL‐6 and PGE2 in a patient‐derived colorectal cancer organoids model by Subtil, Beatriz, Hoorn, Iris A. E., Cuenca‐Escalona, Jorge, Becker, Anouk M. D., Alvarez‐Begue, Mar, Iyer, Kirti K., Janssen, Jorien, Oorschot, Tom, Poel, Dennis, Gorris, Mark A. J., den Dries, Koen, Cambi, Alessandra, Tauriello, Daniele V. F., Vries, I. Jolanda M.

“…Metastatic colorectal cancer (CRC) is highly resistant to therapy and prone to recur. The tumor‐induced local and systemic immunosuppression allows cancer…”
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Human Dendritic Cell Subset Isolation by Magnetic Bead Sorting: A Protocol to Efficiently Obtain Pure Populations by Flórez-Grau, Georgina, Cuenca Escalona, Jorge, Lacasta-Mambo, Helena, Roelofs, Daphne, Bödder, Johanna, Beuk, Ruben, Schreibelt, Gerty, de Vries, I Jolanda

“…Dendritic cells have been investigated for cell-based immunotherapy for various applications. The low abundance of dendritic cells in blood hampers their…”
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Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by tetraspanin CD37 by Peeters, Rens, Cuenca-Escalona, Jorge, Zaal, Esther A., Hoekstra, Anna T., Balvert, Anouk C. G., Vidal-Manrique, Marcos, Blomberg, Niek, van Deventer, Sjoerd J., Stienstra, Rinke, Jellusova, Julia, Giera, Martin, Hannibal, Luciana, Spiekerkoetter, Ute, ter Beest, Martin, Berkers, Celia R., van Spriel, Annemiek B.

“…The importance of fatty acid (FA) metabolism in cancer is well-established, yet the mechanisms underlying metabolic reprogramming remain elusive. Here, we…”
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Dendritic cell phenotype and function in a 3D co-culture model of patient-derived metastatic colorectal cancer organoids by Subtil, Beatriz, Iyer, Kirti K, Poel, Dennis, Bakkerus, Lotte, Gorris, Mark A J, Escalona, Jorge Cuenca, van den Dries, Koen, Cambi, Alessandra, Verheul, Henk M W, de Vries, I Jolanda M, Tauriello, Daniele V F

“…Colorectal cancer (CRC) remains one of the most aggressive and lethal cancers, with metastasis accounting for most deaths. As such, there is an unmet need for…”
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EP2 and EP4 blockade prevents tumor-induced suppressive features in human monocytic myeloid-derived suppressor cells by Cuenca-Escalona, Jorge, Subtil, Beatriz, Garcia-Perez, Alba, Cambi, Alessandra, de Vries, I Jolanda M, Flórez-Grau, Georgina

“…Tumors educate their environment to prime the occurrence of suppressive cell subsets, which enable tumor evasion and favors tumor progression. Among these,…”
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Efficient targeting of NY-ESO-1 tumor antigen to human cDC1s by lymphotactin results in cross-presentation and antigen-specific T cell expansion by Le Gall, Camille, Cammarata, Anna, de Haas, Lukas, Ramos-Tomillero, Iván, Cuenca-Escalona, Jorge, Schouren, Kayleigh, Wijfjes, Zacharias, Becker, Anouk M D, Bödder, Johanna, Dölen, Yusuf, de Vries, I Jolanda M, Figdor, Carl G, Flórez-Grau, Georgina, Verdoes, Martijn

“…BackgroundType 1 conventional dendritic cells (cDC1s) are characterized by their ability to induce potent CD8+ T cell responses. In efforts to generate novel…”
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EP2/EP4 targeting prevents tumor-derived PGE2-mediated immunosuppression in cDC2s by Cuenca-Escalona, Jorge, Bödder, Johanna, Subtil, Beatriz, Sánchez-Sánchez, Marta, Vidal-Manrique, Marcos, Sweep, Mark W D, Fauerbach, Jonathan A, Cambi, Alessandra, Flórez-Grau, Georgina, de Vries, I Jolanda M

“…Tumor-derived prostaglandin E2 (PGE2) impairs anti-tumor immunity by priming suppressive functions on various immune cell types, including dendritic cells…”
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Myeloid-derived suppressor cells and tolerogenic dendritic cells are distinctively induced by PI3K and Wnt signaling pathways by van Wigcheren, Glenn F., Cuenca-Escalona, Jorge, Stelloo, Suzan, Brake, Julia, Peeters, Eline, Horrevorts, Sophie.K., Frölich, Siebren, Ramos-Tomillero, Iván, Wesseling-Rozendaal, Yvonne, van Herpen, Carla M.L., van de Stolpe, Anja, Vermeulen, Michiel, de Vries, I. Jolanda M., Figdor, Carl G., Flórez-Grau, Georgina

“…Imbalanced immune responses are a prominent hallmark of cancer and autoimmunity. Overactive as well as suppressed immunological activity is evidenced to…”
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Pedf derived peptides affect colorectal cancer cell lines resistance and tumour re-growth capacity by Honrubia-Gómez, Paloma, López-Garrido, María-Pilar, Gil-Gas, Carmen, Sánchez-Sánchez, José, Alvarez-Simon, Carmen, Cuenca-Escalona, Jorge, Perez, Ana Ferrer, Arias, Enrique, Moreno, Raul, Sánchez-Sánchez, Francisco, Ramirez-Castillejo, Carmen

“…Relapse after chemotherapy treatment depends on the cancer initiating cells (CICs). PEDF (Pigmented Epithelium Derived Factor) is an anti-angiogenic,…”
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