Search Results - "Erzurum, S. C."

An airway epithelial iNOS–DUOX2–thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma by Voraphani, N, Gladwin, M T, Contreras, A U, Kaminski, N, Tedrow, J R, Milosevic, J, Bleecker, E R, Meyers, D A, Ray, A, Ray, P, Erzurum, S C, Busse, W W, Zhao, J, Trudeau, J B, Wenzel, S E

“…Severe refractory asthma is associated with enhanced nitrative stress. To determine the mechanisms for high nitrative stress in human severe asthma (SA),…”
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eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS‐identified asthma genes by Li, X., Hastie, A. T., Hawkins, G. A., Moore, W. C., Ampleford, E. J., Milosevic, J., Li, H., Busse, W. W., Erzurum, S. C., Kaminski, N., Wenzel, S. E., Meyers, D. A., Bleecker, E. R.

“…Background Genome‐wide association studies (GWASs) have identified various genes associated with asthma, yet, causal genes or single nucleotide polymorphisms…”
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Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans by Erzurum, S.C, Ghosh, S, Janocha, A.J, Xu, W, Bauer, S, Bryan, N.S, Tejero, J, Hemann, C, Hille, R, Stuehr, D.J, Feelisch, M, Beall, C.M

“…The low barometric pressure at high altitude causes lower arterial oxygen content among Tibetan highlanders, who maintain normal levels of oxygen use as…”
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Human Airway Epithelial Cell Determinants of Survival and Functional Phenotype for Primary Human Mast Cells by Hsieh, F. H., Sharma, P., Gibbons, A., Goggans, T., Erzurum, S. C., Haque, S. J., Austen, K. Frank

“…Mast cells (MCs) are found in increased numbers at airway mucosal surfaces in asthmatic patients. Because human airway epithelial cells (HAECs) actively…”
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Eosinophils Are a Major Source of Nitric Oxide-Derived Oxidants in Severe Asthma: Characterization of Pathways Available to Eosinophils for Generating Reactive Nitrogen Species by MacPherson, Jennifer C, Comhair, Suzy A. A, Erzurum, Serpil C, Klein, Dennis F, Lipscomb, Mary F, Kavuru, Mani S, Samoszuk, Michael K, Hazen, Stanley L

“…Eosinophil recruitment and enhanced production of NO are characteristic features of asthma. However, neither the ability of eosinophils to generate NO-derived…”
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Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells by COMHAIR, SUZY A. A., BHATHENA, PERCY R., FARVER, CAROL, THUNNISSEN, FREDERIK B. J. M., ERZURUM, SERPIL C.

“…ABSTRACT A critical first‐line antioxidant defense on the airway epithelial surface against reactive oxygen and nitrogen species (ROS and RNS) is extracellular…”
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Rapid loss of superoxide dismutase activity during antigen-induced asthmatic response by Comhair, Suzy A.A., Bhathena, Percy R., Dweik, Raed A., Kavuru, Mani, Erzurum, Serpil C.

“…Loss of superoxide dismutase activity occurs within minutes of an acute asthmatic response to segmental antigen instillation into the lung of individuals with…”
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Continuous Nitric Oxide Synthesis by Inducible Nitric Oxide Synthase in Normal Human Airway Epithelium in vivo by Guo, Fuhua H., De Raeve, Hilde R., Rice, Thomas W., Stuehr, Dennis J., Frederic B. J. M. Thunnissen, Erzurum, Serpil C.

“…Nitric oxide (NO) is an important mediator of inflammatory responses in the lung and a key regulator of bronchomotor tone. An airway NO synthase (NOS; EC…”
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Decreased Cu,Zn-SOD activity in asthmatic airway epithelium: correction by inhaled corticosteroid in vivo by De Raeve, H R, Thunnissen, F B, Kaneko, F T, Guo, F H, Lewis, M, Kavuru, M S, Secic, M, Thomassen, M J, Erzurum, S C

“…To investigate the antioxidant response of respiratory epithelium to the chronic airway inflammation in asthma, the major intracellular antioxidants [copper…”
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Biochemical reaction products of nitric oxide as quantitative markers of primary pulmonary hypertension by KANEKO, F. T, ARROLIGA, A. C, DWEIK, R. A, COMHAIR, S. A, LASKOWSKI, D, OPPEDISANO, R, THOMASSEN, M. J, ERZURUM, S. C

“…Primary pulmonary hypertension (PPH) is a rare and fatal disease of unknown etiology. Inflammatory oxidant mechanisms and deficiency in nitric oxide (NO) have…”
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Adenoviral reporter gene transfer to the human trabecular meshwork does not alter aqueous humor outflow. Relevance for potential gene therapy of glaucoma by BORRAS, T, ROWLETTE, L. L, ERZURUM, S. C, EPSTEIN, D. L

“…Obstruction of the aqueous humor outflow from the anterior chamber of the eye leads to an elevation of intraocular pressure in glaucoma, the second major cause…”
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Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators by Guo, F H, Uetani, K, Haque, S J, Williams, B R, Dweik, R A, Thunnissen, F B, Calhoun, W, Erzurum, S C

“…Human respiratory epithelium expresses inducible nitric oxide synthase (iNOS) continuously in vivo, however mechanisms responsible for maintenance of…”
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Mechanisms of lipopolysaccharide-induced neutrophil retention. Relative contributions of adhesive and cellular mechanical properties by Erzurum, SC, Downey, GP, Doherty, DE, Schwab, B, 3d, Elson, EL, Worthen, GS

“…Intravascular LPS rapidly induces neutrophil sequestration in pulmonary capillaries by mechanisms that, although currently unknown, must take into account the…”
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Increased glutathione and glutathione peroxidase in lungs of individuals with chronic beryllium disease by COMHAIR, S. A. A, LEWIS, M. J, BHATHENA, P. R, HAMMEL, J. P, ERZURUM, S. C

“…Reactive oxygen species (ROS) are mediators of chronic tissue damage and fibrosis. Endogenous antioxidants may increase in response to oxidants and reduce…”
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Nitric oxide regulation of asthmatic airway inflammation with segmental allergen challenge by Thomassen, Mary Jane, Raychaudhuri, Baisakhi, Dweik, Raed A., Farver, Carol, Buhrow, Lisa, Malur, Anagha, Connors, Mary J., Drazba, Judy, Hammel, Jeffrey, Erzurum, Serpil C., Kavuru, Mani S.

“…Background: Despite evidence of increased nitric oxide (NO) in asthmatic compared with healthy individuals, the role of NO in airway inflammation is unclear…”
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High levels of nitric oxide in individuals with pulmonary hypertension receiving epoprostenol therapy by Ozkan, M, Dweik, R A, Laskowski, D, Arroliga, A C, Erzurum, S C

“…Lack of vasodilator substances, such as nitric oxide (NO), has been implicated in the development of pulmonary hypertension, but the pathogenesis of the…”
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Double-Stranded RNA Dependence of Nitric Oxide Synthase 2 Expression in Human Bronchial Epithelial Cell Lines BET-1A and BEAS-2B by Uetani, Kohsaku, Arroliga, Mercedes E, Erzurum, Serpil C

“…The human airway epithelium expresses abundant nitric oxide synthase 2 (NOS2) in vivo. Although NOS2 is easily induced by cytokines in primary cultured human…”
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Differential expression of manganese superoxide dismutase and catalase in lung cancer by HO, James Chung-Man, SHUO ZHENG, COMHAIR, Suzy A. A, FARVER, Carol, ERZURUM, Serpil C

“…Reactive oxygen species (ROS) are important in the initiation and promotion of cells to neoplastic growth. In this context, cigarette smoke exposure, the…”
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High Levels of Exhaled Nitric Oxide (NO) and NO Synthase III Expression in Lesional Smooth Muscle in Lymphangioleiomyomatosis by Dweik, Raed A, Laskowski, Daniel, Ozkan, Metin, Farver, Carol, Erzurum, Serpil C

“…Smooth-muscle proliferation is the hallmark of lymphangioleiomyomatosis (LAM). Although little is known about the pathogenesis of LAM, nitric oxide (NO) is a…”
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In vivo antioxidant gene expression in human airway epithelium of normal individuals exposed to 100% O2 by Erzurum, S C, Danel, C, Gillissen, A, Chu, C S, Trapnell, B C, Crystal, R G

“…Human bronchial epithelium is exquisitely sensitive to high O2 levels, with tracheobronchitis usually developing after 12 h of exposure to 100% O2. To evaluate…”
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