Search Results - "Ervin, Samantha M."

Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens by Ervin, Samantha M., Li, Hao, Lim, Lauren, Roberts, Lee R., Liang, Xue, Mani, Sridhar, Redinbo, Matthew R.

“…Gut microbial β-glucuronidase (GUS) enzymes have been suggested to be involved in the estrobolome, the collection of microbial reactions involving estrogens…”
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Relationship Between the Gut Microbiome and Systemic Chemotherapy by Ervin, Samantha M., Ramanan, Siddharth Venkat, Bhatt, Aadra P.

“…The intestinal microbiome encodes vast metabolic potential, and multidisciplinary approaches are enabling a mechanistic understanding of how bacterial enzymes…”
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The Gut Microbiota Impact Cancer Etiology through "Phase IV Metabolism" of Xenobiotics and Endobiotics by Ervin, Samantha M, Redinbo, Matthew R

“…The human gut microbiome intimately complements the human genome and gut microbial factors directly influence health and disease. Here we outline how the gut…”
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Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases by Ervin, Samantha M, Simpson, Joshua B, Gibbs, Morgan E, Creekmore, Benjamin C, Lim, Lauren, Walton, William G, Gharaibeh, Raad Z, Redinbo, Matthew R

“…Phase II drug metabolism inactivates xenobiotics and endobiotics through the addition of either a glucuronic acid or sulfate moiety prior to excretion, often…”
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Targeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial β‑Glucuronidases by Ervin, Samantha M, Hanley, Ronan P, Lim, Lauren, Walton, William G, Pearce, Kenneth H, Bhatt, Aadra P, James, Lindsey I, Redinbo, Matthew R

“…Regorafenib (Stivarga) is an oral small molecule kinase inhibitor used to treat metastatic colorectal cancer, hepatocellular carcinomas, and gastrointestinal…”
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Discovery and Characterization of FMN-Binding β-Glucuronidases in the Human Gut Microbiome by Pellock, Samuel J., Walton, William G., Ervin, Samantha M., Torres-Rivera, Dariana, Creekmore, Benjamin C., Bergan, Grace, Dunn, Zachary D., Li, Bo, Tripathy, Ashutosh, Redinbo, Matthew R.

“…The human gut microbiota encodes β-glucuronidases (GUSs) that play key roles in health and disease via the metabolism of glucuronate-containing carbohydrates…”
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Active site flexibility revealed in crystal structures of Parabacteroides merdae β‐glucuronidase from the human gut microbiome by Little, Michael S., Ervin, Samantha M., Walton, William G., Tripathy, Ashutosh, Xu, Yongmei, Liu, Jian, Redinbo, Matthew R.

“…β‐Glucuronidase (GUS) enzymes in the gastrointestinal tract are involved in maintaining mammalian‐microbial symbiosis and can play key roles in drug efficacy…”
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A quantitative method for determining a representative detection limit of the forensic luminol test for latent bloodstains by Cassidy, Brianna M., Lu, Zhenyu, Martin, Jennifer P., Tazik, Shawna K., Kellogg, Katie W., DeJong, Stephanie A., Belliveau, Elle O., Kilgore, Katherine E., Ervin, Samantha M., Meece-Rayle, Mackenzie, Abraham, Alyssa M., Myrick, Michael L., Morgan, Stephen L.

“…[Display omitted] •Novel method for determining the detection limit of the luminol for bloodstains.•Bloodstain samples were prepared reproducibly using a novel…”
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Active site flexibility revealed in crystal structures of Parabacteroides merdae β-glucuronidase from the human gut microbiome: Crystal Structure of P. merdae β-Glucuronidase by Little, Michael S., Ervin, Samantha M., Walton, William G., Tripathy, Ashutosh, Xu, Yongmei, Liu, Jian, Redinbo, Matthew R.

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Structure, Function, and Inhibition of Gut Microbial Enzymes by Ervin, Samantha M

“…The human gut microbiome is one of the most biochemically rich ecosystems in nature, with approximately 1000 bacterial species, trillions of cells, and…”
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