Search Results - "Ervin, John F"

Neuropathological associations of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) differ between the oldest-old and younger-old by Wang, Shih-Hsiu J., Guo, Yuanyuan, Ervin, John F., Lusk, Jay B., Luo, Sheng

“…Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is most often seen in the oldest-old (≥ 90 years of age) but can also…”
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Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease by Wander, Connor M, Tsujimoto, Tamy Harumy Moraes, Ervin, John F, Wang, Chanung, Maranto, Spencer M, Bhat, Vanya, Dallmeier, Julian D, Wang, Shih-Hsiu Jerry, Lin, Feng-Chang, Scott, William K, Holtzman, David M, Cohen, Todd J

“…Corpora amylacea (CA) and their murine analogs, periodic acid Schiff (PAS) granules, are age-related, carbohydrate-rich structures that serve as waste…”
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Neuropathologic, biochemical, and molecular characterization of the frontotemporal dementias by MOTT, Ryan T, DICKSON, Dennis W, HULETTE, Christine M, TROJANOWSKI, John Q, ZHUKAREVA, Vicki, LEE, Virginia M, FORMAN, Mark, VAN DEERLIN, Vivianna, ERVIN, John F, WANG, Deng-Shun, SCHMECHEL, Donald E

“…The frontotemporal dementias (FTDs) are a heterogeneous group of neurodegenerative disorders that are characterized clinically by dementia, personality…”
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Star-shaped TDP-43 inclusions in the oldest-old by Connolly, Erin E, Ervin, John F, Plassman, Brenda L, Welsh-Bohmer, Kathleen A, Wang, Shih-Hsiu J

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Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts by Nelson, Peter T., Brayne, Carol, Flanagan, Margaret E., Abner, Erin L., Agrawal, Sonal, Attems, Johannes, Castellani, Rudolph J., Corrada, Maria M., Cykowski, Matthew D., Di, Jing, Dickson, Dennis W., Dugger, Brittany N., Ervin, John F., Fleming, Jane, Graff-Radford, Jonathan, Grinberg, Lea T., Hokkanen, Suvi R. K., Hunter, Sally, Kapasi, Alifiya, Kawas, Claudia H., Keage, Hannah A. D., Keene, C. Dirk, Kero, Mia, Knopman, David S., Kouri, Naomi, Kovacs, Gabor G., Labuzan, Sydney A., Larson, Eric B., Latimer, Caitlin S., Leite, Renata E. P., Matchett, Billie J., Matthews, Fiona E., Merrick, Richard, Montine, Thomas J., Murray, Melissa E., Myllykangas, Liisa, Nag, Sukriti, Nelson, Ruth S., Neltner, Janna H., Nguyen, Aivi T., Petersen, Ronald C., Polvikoski, Tuomo, Reichard, R. Ross, Rodriguez, Roberta D., Suemoto, Claudia K., Wang, Shih-Hsiu J., Wharton, Stephen B., White, Lon, Schneider, Julie A.

“…Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and Alzheimer’s disease neuropathologic change (ADNC) are each associated…”
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Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is independently associated with dementia and strongly associated with arteriolosclerosis in the oldest-old by Harrison, William T., Lusk, Jay B., Liu, Beiyu, Ervin, John F., Johnson, Kim G., Green, Cynthia L., Wang, Shih-Hsiu J.

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Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation by Wu, Ling, Gilyazova, Nailya, Ervin, John F., Wang, Shih-Hsiu J., Xu, Bin

“…Tau aggregates are present in multiple neurodegenerative diseases known as “tauopathies,” including Alzheimer’s disease (AD), Pick’s disease (PiD), progressive…”
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Correction to: Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is independently associated with dementia and strongly associated with arteriolosclerosis in the oldest-old by Harrison, William T., Lusk, Jay B., Liu, Beiyu, Ervin, John F., Johnson, Kim G., Green, Cynthia L., Wang, Shih-Hsiu J.

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GABA signaling triggered by TMC-1/Tmc delays neuronal aging by inhibiting the PKC pathway in C. elegans by Wu, Jieyu, Wang, Liuyang, Ervin, John F, Wang, Shih-Hsiu J, Soderblom, Erik, Ko, Dennis, Yan, Dong

“…Aging causes functional decline and degeneration of neurons and is a major risk factor of neurodegenerative diseases. To investigate the molecular mechanisms…”
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The human brainome: network analysis identifies HSPA2 as a novel Alzheimer's disease target by Petyuk, Vladislav A, Chang, Rui, Ramirez-Restrepo, Manuel, Beckmann, Noam D, Henrion, Marc Y R, Piehowski, Paul D, Zhu, Kuixi, Wang, Sven, Clarke, Jennifer, Huentelman, Matthew J, Xie, Fang, Andreev, Victor, Engel, Anzhelika, Guettoche, Toumy, Navarro, Loida, De Jager, Philip, Schneider, Julie A, Morris, Christopher M, McKeith, Ian G, Perry, Robert H, Lovestone, Simon, Woltjer, Randall L, Beach, Thomas G, Sue, Lucia I, Serrano, Geidy E, Lieberman, Andrew P, Albin, Roger L, Ferrer, Isidre, Mash, Deborah C, Hulette, Christine M, Ervin, John F, Reiman, Eric M, Hardy, John A, Bennett, David A, Schadt, Eric, Smith, Richard D, Myers, Amanda J

“…By integrating genome, transcriptome and proteome data, Petyuk et al. identify HSPA2 as a driver of pathology in Alzheimer's disease, replicating the finding…”
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The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease by Linnertz, Colton, Lutz, Michael W, Ervin, John F, Allen, Jawara, Miller, Natalie R, Welsh-Bohmer, Kathleen A, Roses, Allen D, Chiba-Falek, Ornit

“…The molecular genetic basis that leads to Lewy Body (LB) pathology in 15-20% of Alzheimer disease cases (LBV/AD) was largely unknown. Alpha-synuclein (SNCA)…”
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Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects by Naylor, Jennifer C., Kilts, Jason D., Hulette, Christine M., Steffens, David C., Blazer, Dan G., Ervin, John F., Strauss, Jennifer L., Allen, Trina B., Massing, Mark W., Payne, Victoria M., Youssef, Nagy A., Shampine, Lawrence J., Marx, Christine E.

“…The neurosteroid allopregnanolone has pronounced neuroprotective actions, increases myelination, and enhances neurogenesis. Evidence suggests that…”
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The Neurosteroid Allopregnanolone Is Reduced in Prefrontal Cortex in Alzheimer’s Disease by Marx, Christine E., Trost, William T., Shampine, Lawrence J., Stevens, Robert D., Hulette, Christine M., Steffens, David C., Ervin, John F., Butterfield, Marian I., Blazer, Daniel G., Massing, Mark W., Lieberman, Jeffrey A.

“…Few data are currently available investigating neurosteroids (NS) in Alzheimer’s disease (AD). The NS allopregnanolone may be decreased in serum and plasma in…”
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Mortalin is regulated by APOE in hippocampus of AD patients and by human APOE in TR mice by Osorio, Cristina, Sullivan, Patrick M, He, Dong Ning, Mace, Brian E, Ervin, John F, Strittmatter, Warren J, Alzate, Oscar

“…Abstract Mortalin is a chaperone protein associated with cell survival, stress response, intracellular trafficking, control of cell proliferation,…”
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Cerebrospinal Fluid Dehydroepiandrosterone Levels Are Correlated with Brain Dehydroepiandrosterone Levels, Elevated in Alzheimer’s Disease, and Related to Neuropathological Disease Stage by Naylor, Jennifer C., Hulette, Christine M., Steffens, David C., Shampine, Lawrence J., Ervin, John F., Payne, Victoria M., Massing, Mark W., Kilts, Jason D., Strauss, Jennifer L., Calhoun, Patrick S., Calnaido, Rohana P., Blazer, Daniel G., Lieberman, Jeffrey A., Madison, Roger D., Marx, Christine E.

“…Objective: It is currently unknown whether cerebrospinal fluid (CSF) neurosteroid levels are related to brain neurosteroid levels in humans. CSF and brain…”
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Postmortem Delay Has Minimal Effect on Brain RNA Integrity by Ervin, John F, Heinzen, Erin L, Cronin, Kenneth D, Goldstein, David, Szymanski, Mari H, Burke, James R, Welsh-Bohmer, Kathleen A, Hulette, Christine M

“…The Bryan Alzheimer Disease Research Center obtains postmortem human brain tissue from patients with Alzheimer disease (AD) and cognitively normal control…”
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The distribution of cerebrovascular amyloid in Alzheimer's disease varies with ApoE genotype by Trembath, Dimitri, Ervin, John F, Broom, Lucy, Szymanski, Mari, Welsh-Bohmer, Kathleen, Pieper, Carl, Hulette, Christine M

“…We performed a comparative study to assess cerebral amyloid angiopathy and ApoE genotype in cases of Alzheimer's disease (AD). Ten ApoE 3,3 and ten ApoE 4,4 AD…”
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Cerebrovascular Smooth Muscle Actin Is Increased in Nondemented Subjects With Frequent Senile Plaques at Autopsy: Implications for the Pathogenesis of Alzheimer Disease by Hulette, Christine M, Ervin, John F, Edmonds, Yvette, Antoine, Samantha, Stewart, Nicolas, Szymanski, Mari H, Hayden, Kathleen M, Pieper, Carl F, Burke, James R, Welsh-Bohmer, Kathleen A

“…We previously found that vascular smooth muscle actin (SMA) is reduced in the brains of patients with late stage Alzheimer disease (AD) compared with brains of…”
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Vascular Smooth Muscle Actin Is Reduced in Alzheimer Disease Brain: A Quantitative Analysis by ERVIN, JOHN F, PANNELL, CATHERINE, SZYMANSKI, MARI, WELSH-BOHMER, KATHLEEN, SCHMECHEL, DONALD E, HULETTE, CHRISTINE M

“…We analyzed smooth muscle actin (SMA) immunoreactivity in brain blood vessels of 10 ApoE 4,4 Alzheimer disease (AD) patients and 10 ApoE 3,3 AD patients…”
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Cardiovascular damage in Alzheimer disease: autopsy findings from the Bryan ADRC by Corder, Elizabeth H, Ervin, John F, Lockhart, Evelyn, Szymanski, Mari H, Schmechel, Donald E, Hulette, Christine M

“…Autopsy information on cardiovascular damage was investigated for pathologically confirmed Alzheimer disease (AD) patients (n=84) and non-AD control patients…”
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