Search Results - "Ervasti, Tuomas"

Theophylline-nicotinamide cocrystal formation in physical mixture during storage by Ervasti, Tuomas, Aaltonen, Jaakko, Ketolainen, Jarkko

“…Pharmaceutically relevant properties, such as solubility and dissolution rate, of active pharmaceutical ingredients can be enhanced by cocrystal formation…”
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Continuous manufacturing of extended release tablets via powder mixing and direct compression by Ervasti, Tuomas, Simonaho, Simo-Pekka, Ketolainen, Jarkko, Forsberg, Peter, Fransson, Magnus, Wikström, Håkan, Folestad, Staffan, Lakio, Satu, Tajarobi, Pirjo, Abrahmsén-Alami, Susanna

“…[Display omitted] The aim of the current work was to explore continuous dry powder mixing and direct compression for manufacturing of extended release (ER)…”
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Detection of porosity of pharmaceutical compacts by terahertz radiation transmission and light reflection measurement techniques by Bawuah, Prince, Pierotic Mendia, Alessandra, Silfsten, Pertti, Pääkkönen, Pertti, Ervasti, Tuomas, Ketolainen, Jarkko, Zeitler, J. Axel, Peiponen, Kai-Erik

“…[Display omitted] We report on the non-destructive quantification of the porosity of pharmaceutical compacts (microcrystalline cellulose tablets) by using both…”
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The Comparison of Two Challenging Low Dose APIs in a Continuous Direct Compression Process by Ervasti, Tuomas, Niinikoski, Hannes, Mäki-Lohiluoma, Eero, Leppinen, Heidi, Ketolainen, Jarkko, Korhonen, Ossi, Lakio, Satu

“…Segregation is a common problem in batch-based direct compression (BDC) processes, especially with low-dose tablet products, as is the preparation of a…”
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A Study on the Resolution of a Terahertz Spectrometer for the Assessment of the Porosity of Pharmaceutical Tablets by Ervasti, Tuomas, Silfsten, Pertti, Ketolainen, Jarkko, Peiponen, Kai-Erik

“…In this study, the resolution of a time-domain terahertz spectrometer for tablet porosity measurements was estimated using two sets of pharmaceutical tablets…”
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Characterization of porous media based on the polarimetric matrix models by Savenkov, Sergey, Priezzhev, Alexander, Oberemok, Yevgen, Kolomiets, Ivan, Silfsten, Pertti, Ervasti, Tuomas, Ketolainen, Jarkko, Peiponen, Kai-Erik

“…In this paper, we measured the Mueller matrices of the samples with different porosity in the visible range (the wavelength of the input radiation ) for the…”
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Production and characterization of glibenclamide incorporated PLA filaments for 3D printing by fused deposition modeling by Kukkonen, Juho, Ervasti, Tuomas, Laitinen, Riikka

“…In this work a soaking method for incorporating glibenclamide (GBC), a poorly soluble API, into prefabricated polylactic acid (PLA) filaments intended for 3D…”
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Measuring tablet porosity using multispectral imaging system by Nippolainen, Ervin, Ervasti, Tuomas, Ketolainen, Jarkko, Kamshilin, Alexei A.

“…A multispectral imaging system with computer controlled light source of 16 light emitting diodes is applied for measuring of tablet porosity. The system is…”
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Converting a batch based high-shear granulation process to a continuous dry granulation process; a demonstration with ketoprofen tablets by Taipale-Kovalainen, Krista, Ketolainen, Jarkko, Korhonen, Ossi, Ervasti, Tuomas

“…When one wishes to convert a batch based manufacturing process of an existing tablet product to a continuous process, there are several available strategies…”
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Raman imaging of amorphous-amorphous phase separation in small molecule co-amorphous systems by Kilpeläinen, Tuomas, Pajula, Katja, Ervasti, Tuomas, Uurasjärvi, Emilia, Koistinen, Arto, Korhonen, Ossi

“…[Display omitted] Many new active pharmaceutical ingredients (API) undergoing development have low permeabilities or low aqueous solubilities. However, the…”
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Continuous manufacturing of tablets with PROMIS-line — Introduction and case studies from continuous feeding, blending and tableting by Simonaho, Simo-Pekka, Ketolainen, Jarkko, Ervasti, Tuomas, Toiviainen, Maunu, Korhonen, Ossi

“…Drug manufacturing technology is in the midst of modernization and continuous manufacturing of drug products is especially the focus of great interest. The…”
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Parameter optimization in a continuous direct compression process of commercially batch-produced bisoprolol tablets by Lyytikäinen, Jenna, Stasiak, Pawel, Kubelka, Tomáš, Olenius, Tino, Korhonen, Ossi, Ketolainen, Jarkko, Ervasti, Tuomas

“…[Display omitted] Continuous tablet manufacturing is a competitive option to replace the traditional batch manufacturing approach. The aim of this study was to…”
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Preparation and characterization of hot-melt extruded polycaprolactone-based filaments intended for 3D-printing of tablets by Viidik, Laura, Vesala, Jemina, Laitinen, Riikka, Korhonen, Ossi, Ketolainen, Jarkko, Aruväli, Jaan, Kirsimäe, Kalle, Kogermann, Karin, Heinämäki, Jyrki, Laidmäe, Ivo, Ervasti, Tuomas

“…•Arabic gum as plasticizer promotes the hot-melt extrusion of polycaprolactone-based filaments intended for 3D printing.•Inhomogeneity of a drug-polymer mass…”
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Flowsheet modelling of a powder continuous feeder-mixer system by Dias, Rute C., Korhonen, Ossi, Ketolainen, Jarkko, Lopes, João A., Ervasti, Tuomas

“…[Display omitted] In this study, an integrated flowsheet model of the continuous feeder-mixer system was calibrated, simulated and compared against…”
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The effect of process parameters on a continuous blending process monitored in-line by near-infrared spectroscopy by Dias, Rute C., Korhonen, Ossi, Ketolainen, Jarkko, Ervasti, Tuomas, Lopes, João A.

“…The continuous feeding-mixing system ensures the composition uniformity down to the tableting continuous manufacturing line so that a quality end-product is…”
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Continuous direct compression of a commercially batch-manufactured tablet formulation with two different processing lines by Lyytikäinen, Jenna, Stasiak, Pawel, Kubelka, Tomáš, Bogaerts, Ivan, Wanek, Adam, Stynen, Bart, Holman, James, Ketolainen, Jarkko, Ervasti, Tuomas, Korhonen, Ossi

“…[Display omitted] The transfer from batch-based to continuous tablet manufacturing increases the quality and efficiency of processes. Nonetheless, as in the…”
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Detecting different amorphous – Amorphous phase separation patterns in co-amorphous mixtures with high resolution imaging FTIR spectroscopy by Kilpeläinen, Tuomas, Ervasti, Tuomas, Uurasjärvi, Emilia, Koistinen, Arto, Ketolainen, Jarkko, Korhonen, Ossi, Pajula, Katja

“…[Display omitted] Many active pharmaceutical ingredients (API) in development suffer from low aqueous solubilities. Instead of the crystal form, the amorphous…”
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Challenges encountered in the transfer of atorvastatin tablet manufacturing - commercial batch-based production as a basis for small-scale continuous tablet manufacturing tests by Lyytikäinen, Jenna, Kyllönen, Saini, Ervasti, Tuomas, Komulainen, Eelis, Pekarek, Tomáš, Slunečková, Jitka, Leskinen, Jari, Ketolainen, Jarkko, Kubelka, Tomáš, Stasiak, Pawel, Korhonen, Ossi

“…[Display omitted] As is the case with batch-based tableting processes, continuous tablet manufacturing can be conducted by direct compression or with a…”
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Noninvasive porosity measurement of biconvex tablets using terahertz pulses by Bawuah, Prince, Ervasti, Tuomas, Tan, Nicholas, Zeitler, J. Axel, Ketolainen, Jarkko, Peiponen, Kai-Erik

“…[Display omitted] Biconvex pharmaceutical microcrystalline cellulose (MCC) compacts were investigated by the detection of terahertz (THz) pulse delay in the…”
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Non-contact weight measurement of flat-faced pharmaceutical tablets using terahertz transmission pulse delay measurements by Bawuah, Prince, Silfsten, Pertti, Ervasti, Tuomas, Ketolainen, Jarkko, Zeitler, J. Axel, Peiponen, Kai-Erik

“…[Display omitted] By measuring the time delay of a terahertz pulse traversing a tablet, and hence its effective refractive index, it is possible to…”
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