Search Results - "Ersoy, Baran A."

Fatty acid activation in thermogenic adipose tissue by Steensels, Sandra, Ersoy, Baran A.

“…Channeling carbohydrates and fatty acids to thermogenic tissues, including brown and beige adipocytes, have garnered interest as an approach for the management…”
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Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress by Ersoy, Baran A, Maner-Smith, Kristal M, Li, Yingxia, Alpertunga, Ipek, Cohen, David E

“…The incorporation of excess saturated free fatty acids (SFAs) into membrane phospholipids within the ER promotes ER stress, insulin resistance, and hepatic…”
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Transcriptional Regulation in Non-Alcoholic Fatty Liver Disease by Steensels, Sandra, Qiao, Jixuan, Ersoy, Baran A.

“…Obesity is the primary risk factor for the pathogenesis of non-alcoholic fatty liver disease (NAFLD), the worldwide prevalence of which continues to increase…”
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Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR by Ersoy, Baran A, Pardo, Leonardo, Zhang, Sumei, Thompson, Darren A, Millhauser, Glenn, Govaerts, Cedric, Vaisse, Christian

“…Different key residues mediate melanocortin-4 receptor activation via the agonist αMSH or constitutive activation via interaction of the transmembrane domain…”
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Epinephrine inhibits PI3Kα via the Hippo kinases by Lin, Ting-Yu, Ramsamooj, Shakti, Perrier, Tiffany, Liberatore, Katarina, Lantier, Louise, Vasan, Neil, Karukurichi, Kannan, Hwang, Seo-Kyoung, Kesicki, Edward A., Kastenhuber, Edward R., Wiederhold, Thorsten, Yaron, Tomer M., Huntsman, Emily M., Zhu, Mengmeng, Ma, Yilun, Paddock, Marcia N., Zhang, Guoan, Hopkins, Benjamin D., McGuinness, Owen, Schwartz, Robert E., Ersoy, Baran A., Cantley, Lewis C., Johnson, Jared L., Goncalves, Marcus D.

“…The phosphoinositide 3-kinase p110α is an essential mediator of insulin signaling and glucose homeostasis. We interrogated the human serine, threonine, and…”
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Thioesterase Superfamily Member 2 (Them2) and Phosphatidylcholine Transfer Protein (PC-TP) Interact To Promote Fatty Acid Oxidation and Control Glucose Utilization by Kawano, Yuki, Ersoy, Baran A., Li, Yingxia, Nishiumi, Shin, Yoshida, Masaru, Cohen, David E.

“…Thioesterase superfamily member 2 (Them2) is a mitochondrion-associated long-chain fatty acyl coenzyme A (CoA) thioesterase that is highly expressed in the…”
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Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity by Siljee, Jacqueline E., Wang, Yi, Bernard, Adelaide A., Ersoy, Baran A., Zhang, Sumei, Marley, Aaron, Von Zastrow, Mark, Reiter, Jeremy F., Vaisse, Christian

“…Most monogenic cases of obesity in humans have been linked to mutations in genes encoding members of the leptin–melanocortin pathway. Specifically, mutations…”
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Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet‐induced hepatic glucose production by Shishova, Ekaterina Y., Stoll, Janis M., Ersoy, Baran A., Shrestha, Sudeep, Scapa, Erez F., Li, Yingxia, Niepel, Michele W., Su, Ya, Jelicks, Linda A., Stahl, Gregory L., Glicksman, Marcie A., Gutierrez‐Juarez, Roger, Cuny, Gregory D., Cohen, David E.

“…Phosphatidylcholine transfer protein (PC‐TP, synonym StARD2) is a highly specific intracellular lipid binding protein that is enriched in liver. Coding region…”
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Acyl‐Coenzyme A Thioesterase 9 Traffics Mitochondrial Short‐Chain Fatty Acids Toward De Novo Lipogenesis and Glucose Production in the Liver by Steensels, Sandra, Qiao, Jixuan, Zhang, Yanzhen, Maner‐Smith, Kristal M., Kika, Nourhan, Holman, Corey D., Corey, Kathleen E., Bracken, W. Clay, Ortlund, Eric A., Ersoy, Baran A.

“…Background and Aims Obesity‐induced pathogenesis of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is associated with…”
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Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice by Kabbani, Mohammad, Michailidis, Eleftherios, Steensels, Sandra, Fulmer, Clifton G., Luna, Joseph M., Le Pen, Jérémie, Tardelli, Matteo, Razooky, Brandon, Ricardo-Lax, Inna, Zou, Chenhui, Zeck, Briana, Stenzel, Ansgar F., Quirk, Corrine, Foquet, Lander, Ashbrook, Alison W., Schneider, William M., Belkaya, Serkan, Lalazar, Gadi, Liang, Yupu, Pittman, Meredith, Devisscher, Lindsey, Suemizu, Hiroshi, Theise, Neil D., Chiriboga, Luis, Cohen, David E., Copenhaver, Robert, Grompe, Markus, Meuleman, Philip, Ersoy, Baran A., Rice, Charles M., de Jong, Ype P.

“…Advanced non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging global health problem associated with pre-disposing genetic polymorphisms, most…”
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Hepatology Highlights by Imai, Norihiro, Krisko, Tibor I., Tafesh, Zaid H., Lucero, Catherine, Alves‐Bezerra, Michele, Nicholls, Hayley T., Steensels, Sandra, Ersoy, Baran A., Rosenblatt, Russell, Schwartz, Robert E., Gupta, Vikas, Lominadze, Zurabi, Fortune, Brett E., Brown, Robert S.

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Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case–control study by Calton, Melissa A., Ersoy, Baran A., Zhang, Sumei, Kane, John P., Malloy, Mary J., Pullinger, Clive R., Bromberg, Yana, Pennacchio, Len A., Dent, Robert, McPherson, Ruth, Ahituv, Nadav, Vaisse, Christian

“…Functionally significant heterozygous mutations in the Melanocortin-4 receptor (MC4R) have been implicated in 2.5% of early onset obesity cases in European…”
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Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling by Ersoy, Baran A, Tarun, Akansha, D'Aquino, Katharine, Hancer, Nancy J, Ukomadu, Chinweike, White, Morris F, Michel, Thomas, Manning, Brendan D, Cohen, David E

“…Phosphatidylcholine transfer protein (PC-TP) is a phospholipid-binding protein that is enriched in liver and that interacts with thioesterase superfamily…”
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Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress by Ersoy, Baran A, Maner-Smith, Kristal M, Li, Yingxia, Alpertunga, Ipek, Cohen, David E

“…The incorporation of excess saturated free fatty acids (SFAs) into membrane phospholipids within the ER promotes ER stress, insulin resistance, and hepatic…”
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Probing protein structure and dynamics by second‐derivative ultraviolet absorption analysis of cation–π interactions by Lucas, Laura H., Ersoy, Baran A., Kueltzo, Lisa A., Joshi, Sangeeta B., Brandau, Duane T., Thyagarajapuram, Nagarajan, Peek, Laura J., Middaugh, C. Russell

“…We describe an alternate approach for studying protein structure using the detection of ultraviolet (UV) absorbance peak shifts of aromatic amino acid side…”
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Bariatric surgery outcome in a patient with complete MC4R deficiency by Aslan, Ivy, Ranadive, Sayali A., Ersoy, Baran A., Rogers, Stanley J., Lustig, Robert H., Vaisse, Christian

“…Bariatric surgery is usually successful for treatment of severe obesity. The mechanisms of weight loss after bariatric surgery and the role of central energy…”
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Probing protein structure and dynamics by second-derivative ultraviolet absorption analysis of cation-{pi} interactions by Lucas, Laura H, Ersoy, Baran A, Kueltzo, Lisa A, Joshi, Sangeeta B, Brandau, Duane T, Thyagarajapuram, Nagarajan, Peek, Laura J, Middaugh, C Russell

“…We describe an alternate approach for studying protein structure using the detection of ultraviolet (UV) absorbance peak shifts of aromatic amino acid side…”
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Deciphering the melanocortin system: Three distinct approaches by Ersoy, Baran A

“…Human obesity is a multi-factorial trait regulated by environmental and genetic factors and is considered to be a global epidemic associated with mortality…”
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Deciphering the melanocortin system: Three distinct approaches by Ersoy, Baran A

“…Human obesity is a multi-factorial trait regulated by environmental and genetic factors and is considered to be a global epidemic associated with mortality…”
Get full text