Search Results - "Ersfeld, Klaus"

The role of the Kinesin-13 family protein TbKif13-2 in flagellar length control of Trypanosoma brucei by Chan, Kuan Yoow, Ersfeld, Klaus

“…Trypanosoma brucei contains at least five microtubule-depolymerising kinesins, but the flagellar kinesin TbKif13-2 has only a moderate effect on flagellar…”
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Novel Cytoskeleton-Associated Proteins in Trypanosoma brucei Are Essential for Cell Morphogenesis and Cytokinesis by Schock, Marina, Schmidt, Steffen, Ersfeld, Klaus

“…Trypanosome brucei, the causative agent of African sleeping sickness, harbours a highly ordered, subpellicular microtubule cytoskeleton that defines many…”
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Evolutionary relationships and protein domain architecture in an expanded calpain superfamily in kinetoplastid parasites by Ersfeld, Klaus, Barraclough, Helen, Gull, Keith

“…Employing whole-genome analysis we have characterized a large family of genes coding for calpain-related proteins in three kinetoplastid parasites. We have…”
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TbKINX1B: a novel BILBO1 partner and an essential protein in bloodstream form Trypanosoma brucei by Perdomo, Doranda, Berdance, Elodie, Lallinger-Kube, Gertrud, Sahin, Annelise, Dacheux, Denis, Landrein, Nicolas, Cayrel, Anne, Ersfeld, Klaus, Bonhivers, Mélanie, Kohl, Linda, Robinson, Derrick R

“…The flagellar pocket (FP) of the pathogen Trypanosoma brucei is an important single copy structure that is formed by the invagination of the pellicular…”
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Distinct and overlapping roles for two Dicer-like proteins in the RNA interference pathways of the ancient eukaryote Trypanosoma brucei by Patrick, Kristin L, Shi, Huafang, Kolev, Nikolay G, Ersfeld, Klaus, Tschudi, Christian, Ullu, Elisabetta

“…Trypanosoma brucei is one of the most ancient eukaryotes where RNA interference (RNAi) is operational and is the only single-cell pathogen where RNAi has been…”
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Functional characterisation and drug target validation of a mitotic kinesin-13 in Trypanosoma brucei by Chan, Kuan Yoow, Matthews, Keith R, Ersfeld, Klaus

“…Mitotic kinesins are essential for faithful chromosome segregation and cell proliferation. Therefore, in humans, kinesin motor proteins have been identified as…”
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Repetitive Elements in Genomes of Parasitic Protozoa by WICKSTEAD, Bill, ERSFELD, Klaus, GULL, Keith

“…Article Usage Stats Services MMBR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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CAP5.5, a life-cycle-regulated, cytoskeleton-associated protein is a member of a novel family of calpain-related proteins in Trypanosoma brucei by Hertz-Fowler, Christiane, Ersfeld, Klaus, Gull, Keith

“…The cell shape of African trypanosomes is determined by the presence of an extensive subpellicular microtubule cytoskeleton. Other possible functions of the…”
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Targeting of cytoskeletal proteins to the flagellum of Trypanosoma brucei by Ersfeld, K, Gull, K

“…The eukaryotic flagellum represents one of the most complex macromolecular structures found in any organism and contains more than 250 proteins. Due to the…”
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Nuclear architecture, genome and chromatin organisation in Trypanosoma brucei by Ersfeld, Klaus

“…The nucleus of the human pathogen Trypanosoma brucei not only has unusual chromosomal composition, characterised by the presence of megabase, intermediate and…”
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Functional characterization of cohesin SMC3 and separase and their roles in the segregation of large and minichromosomes in Trypanosoma brucei by Bessat, Mohamed, Ersfeld, Klaus

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Functional characterization of cohesin SMC 3 and separase and their roles in the segregation of large and minichromosomes in T rypanosoma brucei by Bessat, Mohamed, Ersfeld, Klaus

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Functional characterization of cohesin SMC3 and separase and their roles in the segregation of large and minichromosomes in Trypanosoma brucei by Bessat, Mohamed, Ersfeld, Klaus

“…Minichromosomes in the nuclear genome of Trypanosoma brucei exhibit unusual patterns of mitotic segregation. To address whether differences in their mode of…”
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The calpains: modular designs and functional diversity by Croall, Dorothy E, Ersfeld, Klaus

“…The calpain family is named for the calcium dependence of the papain-like, thiol protease activity of the well-studied ubiquitous vertebrate enzymes calpain-1…”
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Microtubule polyglutamylation is important for regulating cytoskeletal architecture and motility in Trypanosoma brucei by Jentzsch, Jana, Sabri, Adal, Speckner, Konstantin, Lallinger-Kube, Gertrud, Weiss, Matthias, Ersfeld, Klaus

“…The shape of kinetoplastids, such as , is precisely defined during the stages of the life cycle and governed by a stable subpellicular microtubule…”
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Microtubule polyglutamylation is an essential regulator of cytoskeletal integrity in Trypanosoma brucei by Jana, Jentzsch, Wunderlich, Hannes, Thein, Marinus, Bechthold, Julia, Brehm, Lucas, Krauß, Sebastian W, Weiss, Matthias, Ersfeld, Klaus

“…Tubulin polyglutamylation, catalysed by members of the tubulin tyrosine ligase-like (TTLL) protein family, is an evolutionarily highly conserved mechanism…”
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Nuclear architecture, genome and chromatin organisation in Trypanosoma brucei: SPECIAL ISSUE ON THE GENOME ORGANISATION OF EUKARYOTIC MICROBES by ERSFELD, Klaus

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Anti-trypanosomal activity of cationic N-heterocyclic carbene gold(I) complexes by Winter, Isabel, Lockhauserbäumer, Julia, Lallinger-Kube, Gertrud, Schobert, Rainer, Ersfeld, Klaus, Biersack, Bernhard

“…[Display omitted] •Gold(I) complexes 1a and 1b showed excellent in vitro activity against T. b. brucei.•1a and 1b quickly destroyed the cytoskeleton of T. b…”
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Improved anticancer and antiparasitic activity of new lawsone Mannich bases by Mahal, Katharina, Ahmad, Aamir, Schmitt, Florian, Lockhauserbäumer, Julia, Starz, Kathrin, Pradhan, Rohan, Padhye, Subhash, Sarkar, Fazlul H., Koko, Waleed S., Schobert, Rainer, Ersfeld, Klaus, Biersack, Bernhard

“…Substituted lawsone Mannich bases 2a–e, 3a–e and 4a–e were prepared and tested for their biological activities. The new fatty alkyl substituted compounds 2a–c…”
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New Antiparasitic Bis‐Naphthoquinone Derivatives by Jentzsch, Jana, Koko, Waleed S., Al Nasr, Ibrahim S., Khan, Tariq A., Schobert, Rainer, Ersfeld, Klaus, Biersack, Bernhard

“…A series of bis‐naphthoquinone derivatives prepared by condensation of aryl aldehydes with lawsone were tested for antiparasitic activities against Toxoplasma…”
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