Search Results - "Erra, Montse"
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Discovery of a Novel Inhaled PI3Kδ Inhibitor for the Treatment of Respiratory Diseases
Published in Journal of medicinal chemistry (08-11-2018)“…Oral PI3Kδ inhibitors such as Idelalisib and Duvelisib have shown efficacy as anticancer agents and Idelalisib has been approved for the treatment of three…”
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Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases
Published in ACS medicinal chemistry letters (12-01-2017)“…The delta isoform of the phosphatidylinositol 3-kinase (PI3Kδ) has been shown to have an essential role in specific immune cell functions and thus represents a…”
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Highly potent aminopyridines as Syk kinase inhibitors
Published in Bioorganic & medicinal chemistry letters (01-09-2012)“…A novel class of potent Syk inhibitors has been developed from rational design. Highly potent aminopyridine derivatives bearing a 4-trifluoromethyl-2-pyridyl…”
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Biaryl analogues of teriflunomide as potent DHODH inhibitors
Published in Bioorganic & medicinal chemistry letters (15-12-2011)“…The structure–activity relationships of a novel series of biaryl dihydroorotate dehydrogenase (DHODH) inhibitors related to teriflunomide are disclosed. These…”
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